scholarly journals Is Depression or Apathy Playing a Key Role in Predicting Financial Capacity in Parkinson’s Disease with Dementia and Frontotemporal Dementia?

2021 ◽  
Vol 11 (6) ◽  
pp. 785
Author(s):  
Vaitsa Giannouli ◽  
Magda Tsolaki
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Frontotemporal Dementia ◽  
Cognitive Abilities ◽  
Short Form ◽  
Geriatric Depression Scale ◽  
Depression Scale ◽  
Decisive Role ◽  
Financial Capacity ◽  
Capacity Performance

(1) Background: Depression and apathy both affect cognitive abilities, such as thinking, concentration and making decisions in young and old individuals. Although apathy is claimed to be a “core” feature of Parkinson’s disease (PD) and frontotemporal dementia (FTD), it may occur in the absence of depression and vice versa. Thus, the aim of this study is to explore whether depression or apathy better predict financial capacity performance in PD and FTD as well as in nondemented participants. (2) Methods: Eighty-eight participants divided into three groups (PD, FTD and non-demented participants) were examined with the Mini-Mental State Examination (MMSE) and the Legal Capacity for Property Law Transactions Assessment Scale (LCPLTAS)—Full and short form. The Geriatric Depression Scale informant version (GDS-15) and the Irritability-Apathy Scale (IAS) we completed by caregivers. (3) Results: The results indicated that both PD and FTD patients’ general cognitive functioning and financial capacity performance is negatively influenced by apathy and not by depression. (4) Conclusions: Differences in financial capacity performance indicate that apathy should not be disregarded in clinical assessments. Further studies on larger PD and FTD populations are necessary in order to investigate the decisive role of mood factors on financial capacity impairment.

scholarly journals Effect of age on geriatric depression scale performance in Parkinson's disease

2007 ◽  
Vol 22 (9) ◽  
pp. 1331-1335 ◽  
Author(s):  
Daniel Weintraub ◽  
Kirsten Saboe ◽  
Matthew B. Stern
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Geriatric Depression Scale ◽  
Depression Scale ◽  
Geriatric Depression ◽  
Effect Of Age

Depressive symptoms in Parkinson’s disease are related to decreased left hippocampal volume: correlation with the 15-item shortened version of the Geriatric Depression Scale

2017 ◽  
Vol 59 (3) ◽  
pp. 341-345 ◽  
Author(s):  
Masami Goto ◽  
Koji Kamagata ◽  
Taku Hatano ◽  
Nobutaka Hattori ◽  
Osamu Abe ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Geriatric Depression Scale ◽  
Depression Scale ◽  
Hippocampal Volume ◽  
Geriatric Depression ◽  
Matter Volume ◽  
The Relationship

Background The relationship between hippocampal and amygdaloid volumes and depression in patients with Parkinson’s disease (PD) is a controversial issue. Purpose To investigate the correlation between the 15-item shortened version of the Geriatric Depression Scale (GDS-15) and gray matter volume in PD. Material and Methods In the present study, 46 participants with PD were scanned with 3 T magnetic resonance imaging (MRI) to obtain three-dimensional (3D) T1-weighted (T1W) images. Neurologists specializing in movement disorders performed clinical evaluations of the participants (e.g. GDS-15, Mini-Mental State Examination, PD duration, age, sex). Statistical Parametric Mapping 8 software was used for image gray matter segmentation and for a correlation analysis between gray matter volume and GDS-15 score. Results The results showed a significant negative correlation between GDS-15 score and left hippocampal volume, and between GDS-15 score and right parahippocampal gyrus volume. No significant positive correlations were found in the whole brain. Conclusion The current results provide new evidence regarding the relationship between depression in PD and hippocampal volume.

scholarly journals The accuracy of diagnosis of major depression in patients with Parkinson's disease: a comparative study among the UPDRS, the geriatric depression scale and the Beck depression inventory

2008 ◽  
Vol 66 (2a) ◽  
pp. 152-156 ◽  
Author(s):  
Vitor Tumas ◽  
Guilherme Gustavo Ricioppo Rodrigues ◽  
Tarsis Leonardo Almeida Farias ◽  
José Alexandre S. Crippa
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Major Depression ◽  
Beck Depression Inventory ◽  
Geriatric Depression Scale ◽  
Depression Scale ◽  
Diagnostic Value ◽  
Geriatric Depression ◽  
Operating Characteristics ◽  
Highly Correlated

OBJECTIVE: Evaluate the accuracy of diagnosis of major depression in patients with Parkinson's disease (PD) using the UPDRS, the 15-item Geriatric Depression Scale (GDS15) and the Beck Depression Inventory (BDI). METHOD: 50 consecutive patients with PD were evaluated. The diagnosis of major depression was made according to the DSM-IV criteria. RESULTS: We found a 24% prevalence of major depression. All depression scales were highly correlated but UPDRS depression item had the lowest diagnostic value. The GDS15 had the more appropriate "receiver operating characteristics" curve. The best cut-off scores for screening depression were 17/18 for BDI and 8/9 for GDS15. We did not find any correlation between the level of depression and intensity of motor symptoms, functional capacity and duration of the disease. CONCLUSION: GDS15 is better than the BDI and the UPDRS for screening depression in PD and depression is not related to the degree of parkinsonian symptoms.

scholarly journals Reliability and Validity of the Geriatric Depression Scale in Italian Subjects with Parkinson’s Disease

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Perla Massai ◽  
Francesca Colalelli ◽  
Julita Sansoni ◽  
Donatella Valente ◽  
Marco Tofani ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Internal Consistency ◽  
Discriminant Validity ◽  
Geriatric Depression Scale ◽  
Depression Scale ◽  
Reliability And Validity ◽  
Geriatric Depression ◽  
Retest Reliability ◽  
Test Retest Reliability

Introduction. The Geriatric Depression Scale (GDS) is commonly used to assess depressive symptoms, but its psychometric properties have never been examined in Italian people with Parkinson’s disease (PD). The aim of this study was to study the reliability and validity of the Italian version of the GDS in a sample of PD patients. Methods. The GDS was administered to 74 patients with PD in order to study its internal consistency, test-retest reliability, construct, and discriminant validity. Results. The internal consistency of GDS was excellent (α = 0.903), as well as the test-retest reliability (ICC = 0.941 [95% CI: 0.886–0.970]). GDS showed a strong correlation with instruments related to the depression (ρ = 0.880) in PD (ρ = 0.712) and a weak correlation with generic measurement instruments (−0.320 < ρ <−0.217). An area under the curve of 0.892 (95% CI 0.809–0.975) indicated a moderate capability to discriminate depressed patients to nondepressed patient, with a cutoff value between 15 and 16 points that predicts depression (sensitivity = 87%; specificity = 82%). Conclusion. The GDS is a reliable and valid tool in a sample of Italian PD subjects; this scale can be used in clinical and research contexts.

scholarly journals Fatigue in Parkinson’s disease: Brazilian validation of the modified fatigue impact scale

2020 ◽  
Vol 78 (8) ◽  
pp. 473-480
Author(s):  
Josiane LOPES ◽  
Hayslenne Andressa Gonçalves de Oliveira ARAÚJO ◽  
Suhaila Mahmoud SMAILI
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rating Scale ◽  
Intraclass Correlation ◽  
Geriatric Depression Scale ◽  
Depression Scale ◽  
Correlation Coefficients ◽  
Impact Scale ◽  
Fatigue Impact Scale ◽  
The Impact

ABSTRACT Background: The instruments that measure the impact of fatigue on physical, cognitive and psychosocial aspects has yet to be validated in Brazilian population with Parkinson’s disease (PD). The aim of this study was to cross-culturally adapt and assess the psychometric properties of the Brazilian version of the Modified Fatigue Impact Scale (MFIS-PD/BR). Methods: Ninety PD individuals were recruited. The adaptation of the MFIS-PD was performed by translation and back translation methodology. Psychometric analysis was applied in order to perform the administration of the socio-clinical questionnaire, Mini-Mental State Examination (MMSE), Unified Parkinson’s Disease Rating Scale (UPDRS Part I-IV), Hoehn-Yahr disability scale (HY), hospital anxiety and depression scale (HADS), Geriatric Depression Scale (GDS), fatigue severity scale (FSS), Parkinson Fatigue Scale (PFS-16), and MFIS-PD/BR with retest of the MFIS-PD/BR after 7 days. Results: The adaptation phase kept the same items of original MFIS-PD. The Cronbach’s alpha for the MFIS-PD/BR was 0.878 when all responses items were scored. The test-retest intraclass correlation coefficients was above 0.80 (p<0.01) for the MFIS-PD/BR score, which was moderately correlated with the HADS, GDS, MDS-UPDRS score total and non-motor experiences of daily living, FSS and PFS-16. It was revealed the MFIS-PD/BR>29 points as cut-off point to indicate fatigued subjects with accuracy of 0.835 (p<0.001). Conclusions: The MFIS-PD/BR is valid and reproducible to use in assessing the fatigue symptom in Brazilian PD subjects.

scholarly journals Investigating Affective and Motor Improvements with Dance in Parkinson’s Disease

2019 ◽  
Author(s):  
Sarah R. Ciantar ◽  
Karolina A. Bearss ◽  
Gabriella Levkov ◽  
Rachel J. Bar ◽  
Joseph F.X. DeSouza
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Affect Regulation ◽  
Geriatric Depression Scale ◽  
Depression Scale ◽  
Motor Symptoms ◽  
Nonmotor Symptoms ◽  
Timed Up And Go ◽  
Dance Class ◽  
Time Points

AbstractBackgroundResearch has supported the notion that dance alleviates motor symptoms for people with Parkinson’s disease (PD) illustrated by observed improvements in gait, balance, and quality of life. However, what remains unclear is whether engaging in weekly dance classes also positively influences nonmotor symptoms of PD, such as affect regulation (mood).ObjectivesTo examine depressive symptoms of participants in a dance program for people with PD, and to extend previous findings on the topics for motor symptoms.MethodsPeople with PD (n=23) and age-matched healthy controls (n=11) between the ages of 58-75 (M=67.91, SD=5.43) participated in a weekly Dance for PD® class. Nonmotor symptoms of PD were assessed using the Geriatric Depression Scale (GDS), administered at three time points over the 1st year of a newly-developed dance program. The Berg Balance Scale (BBS) and the Timed Up and Go (TUG) were also administered at three time points to assess motor function.ResultsLongitudinal mixed methods analysis showed significant improvements in GDS scores, when examining effects of the dance class over the time, with a significant main effect of time (p < 0.01) and condition: pre/post dance class (p < 0.025). Significant improvements were also observed across the motor tests of BBS (p < 0.001) and TUG (p < 0.001) measurements.ConclusionOur findings suggest dance can facilitate positive improvements in both motor and mood related symptoms of PD. These findings show important nonmotor effects of dance as an adjunct treatment for mood that may reduce the burden of this disease.

scholarly journals Focus on Depression in Parkinson’s Disease: A Delphi Consensus of Experts in Psychiatry, Neurology, and Geriatrics

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Luis Agüera-Ortiz ◽  
Rocío García-Ramos ◽  
Francisco J. Grandas Pérez ◽  
Jorge López-Álvarez ◽  
José Manuel Montes Rodríguez ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Disease Risk ◽  
Geriatric Depression Scale ◽  
Depression Scale ◽  
Motor Symptom ◽  
Mild Depression ◽  
Delphi Consensus ◽  
Serotonergic Drugs

Major and minor forms of depression are significant contributors to Parkinson’s disease morbidity and caregiver burden, affecting up to 50% of these patients. Nonetheless, symptoms of depression are still underrecognized and undertreated in this context due to scarcity of evidence and, consequently, consistent clinical guideline recommendations. Here, we carried out a prospective, multicentre, 2-round modified Delphi survey with 49 questions about the aetiopathological mechanisms of depression in Parkinson’s disease (10), clinical features and connections with motor and nonmotor symptoms (10), diagnostic criteria (5), and therapeutic options (24). Items were assessed by a panel of 37 experts (neurologists, psychiatrists, and a geriatrist), and consensus was achieved in 81.6% of them. Depressive symptoms, enhanced by multiple patient circumstances, were considered Parkinson’s disease risk factors but not clinical indicators of motor symptom and disease progression. These patients should be systematically screened for depression while ruling out both anhedonia and apathy symptoms as they are not necessarily linked to it. Clinical scales (mainly the Geriatric Depression Scale GDS-15) can help establishing the diagnosis of depression, the symptoms of which will require treatment regardless of severity. Efficacious and well-tolerated pharmacological options for Parkinson’s comorbid depression were selective serotonin reuptake inhibitors (especially sertraline), dual-action serotonin and norepinephrine reuptake inhibitors (venlafaxine, desvenlafaxine, and duloxetine), multimodal (vortioxetine, bupropion, mirtazapine, and tianeptine), and anti-Parkinsonian dopamine agonists (pramipexole, ropinirole, and rotigotine). Tricyclic antidepressants and combining type B monoamine oxidase inhibitors with serotonergic drugs have serious side effects in these patients and therefore should not be prescribed. Electroconvulsive therapy was indicated for severe and drug-refractory cases. Cognitive behavioural therapy was recommended in cases of mild depression. Results presented here are useful diagnostic and patient management guidance for other physicians and important considerations to improve future drug trial design.

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