scholarly journals Association between Growth Differentiation Factor-15 (GDF-15) Serum Levels, Anorexia and Low Muscle Mass among Cancer Patients

Cancers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 99
Author(s):  
Alessio Molfino ◽  
Maria Ida Amabile ◽  
Giovanni Imbimbo ◽  
Veronica Rizzo ◽  
Federica Pediconi ◽  
...  

The pathophysiology of cancer anorexia is complex and serum biomarkers, including growth and differentiation factor(s) (GDF), may be modulated. We explored the association(s) between GDF-15 serum levels and anorexia and, secondarily, with low muscle mass and body weight loss in cancer patients. We considered gastrointestinal and lung cancer patients (CP) and healthy BMI-matched controls. The FAACT-questionnaire was administered to diagnose anorexia and we calculated the L3-SMI by CT scan to assess low muscularity, setting their cutoff values at the lowest tertile. GDF-15 serum levels were assessed by ELISA. We enrolled 59 CP and 30 controls; among CP, 25 were affected by gastrointestinal and 34 by lung cancer. Anorexia was present in 36% of CP. Gastrointestinal CP resulted more anorexic compared to lung CP (p = 0.0067). Low muscle mass was present in 33.9% of CP and L3-SMI was lower in gastrointestinal compared to lung CP (p = 0.049). The GDF-15 levels were higher in CP vs. controls (p = 0.00016), as well as in anorexic vs. non-anorexic CP (p = 0.005) and vs. controls (p < 0.0001). Gastrointestinal CP showed higher GDF-15 levels vs. lung CP (p = 0.0004). No difference was found in GDF-15 between CP with low muscle mass and those with moderate/high muscularity and between patients with body weight loss and those with stable weight. Our data support the involvement of GDF-15 in the pathogenesis of cancer anorexia. The mechanisms of action of GDF-15 in cancer should be further clarified also regarding the changes in muscularity.

Lung Cancer ◽  
2009 ◽  
Vol 66 (3) ◽  
pp. 393-398 ◽  
Author(s):  
Eleni M. Karapanagiotou ◽  
Aristidis Polyzos ◽  
Kalliopi D. Dilana ◽  
Ioannis Gratsias ◽  
Paraskevi Boura ◽  
...  

2014 ◽  
Vol 5 (2) ◽  
pp. 127-137 ◽  
Author(s):  
Céline M. H. Op den Kamp ◽  
Dirk K. M. De Ruysscher ◽  
Marieke van den Heuvel ◽  
Meike Elferink ◽  
Ruud M. A. Houben ◽  
...  

2019 ◽  
Vol 10 (4) ◽  
pp. 782-793 ◽  
Author(s):  
Sami Antoun ◽  
Hugues Morel ◽  
Pierre‐Jean Souquet ◽  
Veerle Surmont ◽  
David Planchard ◽  
...  

1999 ◽  
Vol 11 (12) ◽  
pp. A25
Author(s):  
H. J. Agteresch ◽  
P. C. Dagnelie ◽  
J. W.O. van den Berg ◽  
J. H.P. Wilson

2020 ◽  
Vol 11 (6) ◽  
pp. 1501-1508
Author(s):  
Jennifer Le‐Rademacher ◽  
Camden Lopez ◽  
Eric Wolfe ◽  
Nathan R. Foster ◽  
Sumithra J. Mandrekar ◽  
...  

2019 ◽  
Vol 11 (12) ◽  
pp. 5643-5645
Author(s):  
Yusuke Takahashi ◽  
Takeo Nakada ◽  
Noriaki Sakakura ◽  
Hiroaki Kuroda

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