scholarly journals The Growing Relevance of Immunoregulation in Pediatric Brain Tumors

Cancers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 5601
Author(s):  
Viktoria Melcher ◽  
Kornelius Kerl
Keyword(s):  
Brain Tumors ◽  
Immune Cells ◽  
Multimodal Therapy ◽  
Malignant Cell ◽  
Pediatric Brain Tumors ◽  
Therapeutic Approaches ◽  
Aggressive Tumors ◽  
Pediatric Brain ◽  
Heterogeneous Solid

Pediatric brain tumors are genetically heterogeneous solid neoplasms. With a prevailing poor prognosis and widespread resistance to conventional multimodal therapy, these aggressive tumors are the leading cause of childhood cancer-related deaths worldwide. Advancement in molecular research revealed their unique genetic and epigenetic characteristics and paved the way for more defined prognostication and targeted therapeutic approaches. Furthermore, uncovering the intratumoral metrics on a single-cell level placed non-malignant cell populations such as innate immune cells into the context of tumor manifestation and progression. Targeting immune cells in pediatric brain tumors entails unique challenges but promising opportunities to improve outcome. Herein, we outline the current understanding of the role of the immune regulation in pediatric brain tumors.

Role of intraoperative ultrasound in resection of pediatric brain tumors

2010 ◽  
Vol 26 (9) ◽  
pp. 1189-1193 ◽  
Author(s):  
Mohamed Ahmed El Beltagy ◽  
Mohamed Aggag ◽  
Mohamed Kamal
Keyword(s):  
Brain Tumors ◽  
Intraoperative Ultrasound ◽  
Pediatric Brain Tumors ◽  
Pediatric Brain

Role of stereotactic radiosurgery and fractionated stereotactic radiotherapy in pediatric brain tumors

2008 ◽  
Vol 8 (1) ◽  
pp. 121-132 ◽  
Author(s):  
Simon S Lo ◽  
Achilles J Fakiris ◽  
Ramzi Abdulrahman ◽  
Mark A Henderson ◽  
Eric L Chang ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Stereotactic Radiosurgery ◽  
Stereotactic Radiotherapy ◽  
Pediatric Brain Tumors ◽  
Fractionated Stereotactic Radiotherapy ◽  
Pediatric Brain

Role of temozolomide in pediatric brain tumors

2006 ◽  
Vol 22 (7) ◽  
pp. 652-661 ◽  
Author(s):  
Giuseppe Barone ◽  
Palma Maurizi ◽  
Giampiero Tamburrini ◽  
Riccardo Riccardi
Keyword(s):  
Brain Tumors ◽  
Pediatric Brain Tumors ◽  
Pediatric Brain

scholarly journals Molecular profiling and targeted therapy in pediatric gliomas: review and consensus recommendations

2019 ◽  
Vol 21 (8) ◽  
pp. 968-980 ◽  
Author(s):  
Zachary Miklja ◽  
Amy Pasternak ◽  
Stefanie Stallard ◽  
Theodore Nicolaides ◽  
Cassie Kline-Nunnally ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Standard Of Care ◽  
Pediatric Brain Tumors ◽  
Molecular Profiling ◽  
Consensus Recommendation ◽  
Pediatric Glioma ◽  
Consensus Recommendations ◽  
Children And Young Adults ◽  
Pediatric Brain

Abstract As the field of neuro-oncology makes headway in uncovering the key oncogenic drivers in pediatric glioma, the role of precision diagnostics and therapies continues to rapidly evolve with important implications for the standard of care for clinical management of these patients. Four studies at major academic centers were published in the last year outlining the clinically integrated molecular profiling and targeting of pediatric brain tumors; all 4 demonstrated the feasibility and utility of incorporating sequencing into the care of children with brain tumors, in particular for children and young adults with glioma. Based on synthesis of the data from these studies and others, we provide consensus recommendations for the integration of precision diagnostics and therapeutics into the practice of pediatric neuro-oncology. Our primary consensus recommendation is that next-generation sequencing should be routinely included in the workup of most pediatric gliomas.

Role of susceptibility-weighted imaging and intratumoral susceptibility signals in grading and differentiating pediatric brain tumors at 1.5 T: a preliminary study

2020 ◽  
Vol 62 (6) ◽  
pp. 705-713
Author(s):  
Simona Gaudino ◽  
Giammaria Marziali ◽  
Giovanna Pezzullo ◽  
Pamela Guadalupi ◽  
Carolina Giordano ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Pediatric Brain Tumors ◽  
Susceptibility Weighted Imaging ◽  
Preliminary Study ◽  
Pediatric Brain

The role of diffusion-weighted magnetic resonance imaging in pediatric brain tumors

2006 ◽  
Vol 22 (11) ◽  
pp. 1435-1439 ◽  
Author(s):  
Peter Kan ◽  
James K. Liu ◽  
Gary Hedlund ◽  
Douglas L. Brockmeyer ◽  
Marion L. Walker ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Brain Tumors ◽  
Pediatric Brain Tumors ◽  
Resonance Imaging ◽  
Diffusion Weighted ◽  
Weighted Magnetic Resonance Imaging ◽  
Pediatric Brain

scholarly journals Role of Peroxisome Proliferator-Activated Receptor Gamma and Its Ligands in the Treatment of Hematological Malignancies

PPAR Research ◽  
2008 ◽  
Vol 2008 ◽  
pp. 1-18 ◽  
Author(s):  
Tatiana M. Garcia-Bates ◽  
Geniece M. Lehmann ◽  
Patricia J. Simpson-Haidaris ◽  
Steven H. Bernstein ◽  
Patricia J. Sime ◽  
...  
Keyword(s):  
Immune Cells ◽  
Hematological Malignancies ◽  
Malignant Cell ◽  
Cellular Growth ◽  
Peroxisome Proliferator ◽  
Therapeutic Approaches ◽  
Peroxisome Proliferator Activated Receptor ◽  
New Therapeutic Approaches ◽  
Leukemias And Lymphomas

Peroxisome proliferator-activated receptor gamma (PPARγ) is a multifunctional transcription factor with important regulatory roles in inflammation, cellular growth, differentiation, and apoptosis. PPARγis expressed in a variety of immune cells as well as in numerous leukemias and lymphomas. Here, we review recent studies that provide new insights into the mechanisms by which PPARγligands influence hematological malignant cell growth, differentiation, and survival. Understanding the diverse properties of PPARγligands is crucial for the development of new therapeutic approaches for hematological malignancies.

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