scholarly journals Serum Anti-Müllerian Hormone Levels and Risk of Premature Ovarian Insufficiency in Female Childhood Cancer Survivors: Systematic Review and Network Meta-Analysis

Cancers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 6331
Author(s):  
Marco Torella ◽  
Gaetano Riemma ◽  
Pasquale De Franciscis ◽  
Marco La Verde ◽  
Nicola Colacurci
Keyword(s):  
Systematic Review ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Ovarian Reserve ◽  
Meta Analysis ◽  
Childhood Cancer Survivors ◽  
Premature Ovarian Insufficiency ◽  
Control Group ◽  
Ovarian Insufficiency ◽  
Increased Risk

Background: Female childhood cancer survivors (CCS) might have impaired ovarian reserves, especially after alkylating agents or radiotherapy. The purpose of this systematic review and network meta-analysis is to evaluate the role of serum anti-Müllerian hormone (AMH) for ovarian reserve screening and the risk of premature ovarian insufficiency (POI) according to the subtype of childhood cancer. (2) Methods: PRISMA-NMA guidelines were followed. We carried out a network meta-analysis based on a random effects model for mixed multiple treatment comparisons to rank childhood cancers effects on fertility by surface under the cumulative ranking curve (SUCRA). Studies were selected only if they had an age-matched control group. Quality assessment was performed using Newcastle–Ottawa Scale. The co-primary outcomes were mean AMH levels and the incidence of POI. (3) Results: A total of 8 studies (1303 participants) were included. Women treated for a neuroblastoma during infancy were more likely to be ranked first for impaired AMH levels (SUCRA = 65.4%), followed by mixed CCS (SUCRA = 29.6%). The greatest rates of POI were found in neuroblastoma survivors (SUCRA = 42.5%), followed by acute lymphoid leukemia (SUCRA = 26.3%) or any other neoplasia (SUCR A= 20.5%). (4) Conclusions: AMH represents a trustworthy approach for ovarian reserve screening. Direct and indirect comparisons found no differences in mean AMH levels and POI risk between subtypes of CCS and healthy controls. SUCRA analysis showed that female neuroblastoma survivors were more at risk for reduced serum AMH levels and increased risk of POI.

scholarly journals Premature Ovarian Insufficiency in Childhood Cancer Survivors

2018 ◽  
Vol 73 (3) ◽  
pp. 155-156
Author(s):  
Wassim Chemaitilly ◽  
Zhenghong Li ◽  
Matthew J. Krasin ◽  
Russell J. Brooke ◽  
Carmen L. Wilson ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Childhood Cancer ◽  
Childhood Cancer Survivors ◽  
Premature Ovarian Insufficiency ◽  
Ovarian Insufficiency

scholarly journals Premature Ovarian Insufficiency in Childhood Cancer Survivors: A Report From the St. Jude Lifetime Cohort

2017 ◽  
Vol 102 (7) ◽  
pp. 2242-2250 ◽  
Author(s):  
Wassim Chemaitilly ◽  
Zhenghong Li ◽  
Matthew J. Krasin ◽  
Russell J. Brooke ◽  
Carmen L. Wilson ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Childhood Cancer ◽  
Childhood Cancer Survivors ◽  
Premature Ovarian Insufficiency ◽  
Ovarian Insufficiency

scholarly journals Quality of life among female childhood cancer survivors with and without premature ovarian insufficiency

2021 ◽  
Author(s):  
Hjelmér Ida ◽  
Gustafsson Kylberg Alicia ◽  
Fridenborg Anna ◽  
Leijonhufvud Irene ◽  
Nyström Anna ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Childhood Cancer ◽  
Well Being ◽  
Childhood Cancer Survivors ◽  
University Hospital ◽  
Premature Ovarian Insufficiency ◽  
Health State ◽  
Ovarian Insufficiency ◽  
Final Study ◽  
After Cancer

Abstract Purpose Due to an increase in survival, a growing population of childhood cancer survivors (CCS) is present. However, female CCS are at risk of developing premature ovarian insufficiency (POI) after cancer treatment. POI involves a decreased chance of conceiving and the increased infertility state has a large impact on affected individuals’ health and mental life. The objective of this study was to investigate health state and well-being among female CCS with and without POI and healthy controls (HC). Methods Female CCS treated in southern Sweden between 1964 and 2008 were included. Each patient was matched with a HC. The final study population included 167 female CCS and 164 HC that were examined between October 2010 and January 2015 at the Reproductive Medicine Centre at Skåne University Hospital in Malmö, Sweden. All participants, except for two HCs, answered an EQ-5D-3L questionnaire for measuring health state including a visual analogue scale (VAS) for estimating well-being. Results There were 22 CCS with POI, none of the HC had POI. The mean health state differed among groups (unadjusted: P = 0.002; adjusted: P = 0.007). A difference in mean experienced well-being among groups was noted (unadjusted: P = 0.003; adjusted: P = 0.012). Lowest well-being was found in the CCS group with POI (P = 0.024). Conclusions Female CCS have a significantly decreased health state and well-being. Female CCS with POI additionally have the lowest self-estimated well-being. Implications for Cancer Survivors Female CCS with POI should be identified early in order to give them adequate information and support.

scholarly journals Heart failure in childhood cancer survivors – A systematic review protocol

2021 ◽  
Author(s):  
Tove Berg ◽  
Jens Böhmer ◽  
Bright Nwaru ◽  
Kristjan Karason ◽  
Marianne Jarfelt
Keyword(s):  
Heart Failure ◽  
Systematic Review ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Meta Analysis ◽  
Public Health Practice ◽  
Childhood Cancer Survivors ◽  
Population Based ◽  
Cardiac Complications ◽  
Treatment Protocols

Abstract BackgroundOver the past decades, survival rate for childhood cancer has greatly improved. However, the risk of late cardiac complications after such treatment remains high. Previous studies have shown that the risk for heart failure among childhood cancer survivors is significantly higher than that observed in the general population. The aim of this systematic review is to identify, critically appraise and synthesize existing population-based studies reporting on the frequency of heart failure, both incidence or prevalence, that may develop after treatment of childhood cancer.Method:The following databases will be searched from their inception date until May 17th 2021: Medline, Embase, Scopus, CINAHL, CAB International, AMED, Global Health, Psycinfo, Web of science and Google Scholar. Population-based studies reporting on the incidence and/or prevalence of heart failure after treatment of any type of childhood cancer will be included. Screening of articles, data extraction and quality assessment will be performed independently by two reviewers. The quality and risk of bias in the studies included will be assessed by using the Effective Public Health Practice Project tool. A narrative synthesis of the extracted data will be undertaken and, for studies that are sufficiently homogenous, a meta-analysis using random-effects models performed.DiscussionThis systematic review will provide a clearer picture of the epidemiology of heart failure after treatment of childhood cancer. Collected data will be of value for future childhood cancer treatment protocols and also offer guidance for post-treatment cardiac surveillance among survivors.Systematic review registrationThis protocol follows the structure of the recommendation of the preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) and has been submitted in PROSPERO on April 28th 2021, awaiting assignment of registration number.

Is health status impaired in childhood cancer survivors? A systematic review and meta-analysis

2019 ◽  
Vol 142 ◽  
pp. 94-118 ◽  
Author(s):  
Javier S. Morales ◽  
Pedro L. Valenzuela ◽  
Cecilia Rincón-Castanedo ◽  
Alejandro Santos-Lozano ◽  
Carmen Fiuza-Luces ◽  
...  
Keyword(s):  
Systematic Review ◽  
Health Status ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Meta Analysis ◽  
Childhood Cancer Survivors

Late effects of chemo and radiation treatment on dental structures of childhood cancer survivors. A systematic review and meta‐analysis

Head & Neck ◽  
2019 ◽  
Vol 41 (9) ◽  
pp. 3422-3433
Author(s):  
Kyriaki Seremidi ◽  
Dimitrios Kloukos ◽  
Argy Polychronopoulou ◽  
Antonis Kattamis ◽  
Katerina Kavvadia
Keyword(s):  
Systematic Review ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Late Effects ◽  
Radiation Treatment ◽  
Meta Analysis ◽  
Childhood Cancer Survivors

42 - The Prevalence of Diabetes Mellitus in Childhood Cancer Survivors: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 44 (7) ◽  
pp. S19
Author(s):  
Sondra S. Chen ◽  
Ajantha Nadarajah ◽  
Kuan-Wen Wang ◽  
Stephanie Kay ◽  
Laura Banfield ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Meta Analysis ◽  
Childhood Cancer Survivors ◽  
Prevalence Of Diabetes Mellitus
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