Quality of life among female childhood cancer survivors with and without premature ovarian insufficiency

Abstract Purpose Due to an increase in survival, a growing population of childhood cancer survivors (CCS) is present. However, female CCS are at risk of developing premature ovarian insufficiency (POI) after cancer treatment. POI involves a decreased chance of conceiving and the increased infertility state has a large impact on affected individuals’ health and mental life. The objective of this study was to investigate health state and well-being among female CCS with and without POI and healthy controls (HC). Methods Female CCS treated in southern Sweden between 1964 and 2008 were included. Each patient was matched with a HC. The final study population included 167 female CCS and 164 HC that were examined between October 2010 and January 2015 at the Reproductive Medicine Centre at Skåne University Hospital in Malmö, Sweden. All participants, except for two HCs, answered an EQ-5D-3L questionnaire for measuring health state including a visual analogue scale (VAS) for estimating well-being. Results There were 22 CCS with POI, none of the HC had POI. The mean health state differed among groups (unadjusted: P = 0.002; adjusted: P = 0.007). A difference in mean experienced well-being among groups was noted (unadjusted: P = 0.003; adjusted: P = 0.012). Lowest well-being was found in the CCS group with POI (P = 0.024). Conclusions Female CCS have a significantly decreased health state and well-being. Female CCS with POI additionally have the lowest self-estimated well-being. Implications for Cancer Survivors Female CCS with POI should be identified early in order to give them adequate information and support.

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Premature Ovarian Insufficiency in Childhood Cancer Survivors

Obstetrical & Gynecological Survey ◽

10.1097/ogx.0000000000000545 ◽

2018 ◽

Vol 73 (3) ◽

pp. 155-156

Author(s):

Wassim Chemaitilly ◽

Zhenghong Li ◽

Matthew J. Krasin ◽

Russell J. Brooke ◽

Carmen L. Wilson ◽

...

Keyword(s):

Cancer Survivors ◽

Childhood Cancer ◽

Childhood Cancer Survivors ◽

Premature Ovarian Insufficiency ◽

Ovarian Insufficiency

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Serum Anti-Müllerian Hormone Levels and Risk of Premature Ovarian Insufficiency in Female Childhood Cancer Survivors: Systematic Review and Network Meta-Analysis

Cancers ◽

10.3390/cancers13246331 ◽

2021 ◽

Vol 13 (24) ◽

pp. 6331

Author(s):

Marco Torella ◽

Gaetano Riemma ◽

Pasquale De Franciscis ◽

Marco La Verde ◽

Nicola Colacurci

Keyword(s):

Systematic Review ◽

Cancer Survivors ◽

Childhood Cancer ◽

Ovarian Reserve ◽

Meta Analysis ◽

Childhood Cancer Survivors ◽

Premature Ovarian Insufficiency ◽

Control Group ◽

Ovarian Insufficiency ◽

Increased Risk

Background: Female childhood cancer survivors (CCS) might have impaired ovarian reserves, especially after alkylating agents or radiotherapy. The purpose of this systematic review and network meta-analysis is to evaluate the role of serum anti-Müllerian hormone (AMH) for ovarian reserve screening and the risk of premature ovarian insufficiency (POI) according to the subtype of childhood cancer. (2) Methods: PRISMA-NMA guidelines were followed. We carried out a network meta-analysis based on a random effects model for mixed multiple treatment comparisons to rank childhood cancers effects on fertility by surface under the cumulative ranking curve (SUCRA). Studies were selected only if they had an age-matched control group. Quality assessment was performed using Newcastle–Ottawa Scale. The co-primary outcomes were mean AMH levels and the incidence of POI. (3) Results: A total of 8 studies (1303 participants) were included. Women treated for a neuroblastoma during infancy were more likely to be ranked first for impaired AMH levels (SUCRA = 65.4%), followed by mixed CCS (SUCRA = 29.6%). The greatest rates of POI were found in neuroblastoma survivors (SUCRA = 42.5%), followed by acute lymphoid leukemia (SUCRA = 26.3%) or any other neoplasia (SUCR A= 20.5%). (4) Conclusions: AMH represents a trustworthy approach for ovarian reserve screening. Direct and indirect comparisons found no differences in mean AMH levels and POI risk between subtypes of CCS and healthy controls. SUCRA analysis showed that female neuroblastoma survivors were more at risk for reduced serum AMH levels and increased risk of POI.

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Premature Ovarian Insufficiency in Childhood Cancer Survivors: A Report From the St. Jude Lifetime Cohort

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2016-3723 ◽

2017 ◽

Vol 102 (7) ◽

pp. 2242-2250 ◽

Cited By ~ 57

Author(s):

Wassim Chemaitilly ◽

Zhenghong Li ◽

Matthew J. Krasin ◽

Russell J. Brooke ◽

Carmen L. Wilson ◽

...

Keyword(s):

Cancer Survivors ◽

Childhood Cancer ◽

Childhood Cancer Survivors ◽

Premature Ovarian Insufficiency ◽

Ovarian Insufficiency

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Validation of questionnaire-reported chest wall abnormalities with a telephone interview in Swiss childhood cancer survivors

BMC Cancer ◽

10.1186/s12885-021-08425-z ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Rahel Kasteler ◽

Christa Lichtensteiger ◽

Christina Schindera ◽

Marc Ansari ◽

Claudia E. Kuehni ◽

...

Keyword(s):

Risk Factors ◽

Cancer Survivors ◽

Childhood Cancer ◽

Chest Wall ◽

Daily Life ◽

Well Being ◽

Childhood Cancer Survivors ◽

Thoracic Wall ◽

Medical Attention ◽

The Impact

Abstract Background Chest wall abnormalities are a poorly studied complication after treatment for childhood cancer. Chest wall abnormalities are not well-described in the literature, and little is known on the impact on daily life of survivors. Methods We investigated prevalence and risk factors of chest wall abnormalities in childhood cancer survivors in a nationwide, population-based cohort study (Swiss Childhood Cancer Survivor Study) with a questionnaire survey. We then interviewed a nested sample of survivors to validate types of chest wall abnormalities and understand their impact on the daily life of survivors. Results Forty-eight of 2382 (95%CI 2–3%) survivors reported a chest wall abnormality. Risk factors were older age at cancer diagnosis (16–20 years; OR 2.5, 95%CI 1.0–6.1), lymphoma (OR 3.8, 95%CI 1.2–11.4), and central nervous system tumors (OR 9.5, 95%CI 3.0–30.1) as underlying disease, and treatment with thoracic radiotherapy (OR 2.0, 95%CI 1.0–4.2), surgery to the chest (OR 4.5, 95%CI 1.8–11.5), or chemotherapy (OR 2.9, 95%CI 1.0–8.1). The nature of the chest wall abnormalities varied and included thoracic wall deformities (30%), deformations of the spine (5%) or both (55%), and scars (10%). Chest wall abnormalities affected daily life in two thirds (13/20) of those who reported these problems and necessitated medical attention for 15 (75%) survivors. Conclusion It is important that, during follow-up care, physicians pay attention to chest wall abnormalities, which are rare late effects of cancer treatment, but can considerably affect the well-being of cancer survivors.

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Quality of life in long-term childhood cancer survivors and the relation of late effects and subjective well-being

Supportive Care in Cancer ◽

10.1007/s00520-004-0724-0 ◽

2004 ◽

Vol 13 (1) ◽

pp. 49-56 ◽

Cited By ~ 58

Author(s):

Sigrid Pemberger ◽

Reinhold Jagsch ◽

Eva Frey ◽

Rosemarie Felder-Puig ◽

Helmut Gadner ◽

...

Keyword(s):

Quality Of Life ◽

Cancer Survivors ◽

Childhood Cancer ◽

Late Effects ◽

Well Being ◽

Childhood Cancer Survivors ◽

Subjective Well Being

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A vulnerable age group: the impact of cancer on the psychosocial well-being of young adult childhood cancer survivors

Supportive Care in Cancer ◽

10.1007/s00520-021-06009-y ◽

2021 ◽

Author(s):

L. M. E. van Erp ◽

H. Maurice-Stam ◽

L. C. M. Kremer ◽

W. J. E. Tissing ◽

H. J. H. van der Pal ◽

...

Keyword(s):

Young Adults ◽

Young Adult ◽

Cancer Survivors ◽

Childhood Cancer ◽

Psychosocial Outcomes ◽

Well Being ◽

Childhood Cancer Survivors ◽

Negative Impacts ◽

Time Since Diagnosis

Abstract Purpose This study aimed to increase our understanding of the psychosocial well-being of young adult childhood cancer survivors (YACCS) as well as the positive and negative impacts of cancer. Methods YACCS (aged 18–30, diagnosed ≤ 18, time since diagnosis ≥ 5 years) cross-sectionally filled out the “Pediatric Quality of Life Inventory Young Adults” (PedsQL-YA), “Hospital Anxiety and Depression Scale” (HADS), and “Checklist Individual Strengths” (CIS-20R) to measure fatigue and survivor-specific “Impact of Cancer - Childhood Survivors” (IOC-CS), which measures the long-term impact of childhood cancer in several domains. Descriptive statistics (IOC-CS), logistic regression (HADS, CIS-20R), and ANOVA (PedsQL-YA, HADS, CIS-20R) were performed. Associations between positive and negative impacts of childhood cancer and psychosocial outcomes were examined with linear regression analyses. Results YACCS (N = 151, 61.6% female, mean age 24.1 ± 3.6, mean time since diagnosis 13.6 ± 3.8) reported lower HRQOL (− .4 ≤ d ≤ − .5, p ≤ .001) and more anxiety (d = .4, p ≤ .001), depression (d = .4, p ≤ .01), and fatigue (.3 ≤ d ≤ .5, p ≤ .001) than young adults from the general Dutch population. They were at an increased risk of experiencing (sub)clinical anxiety (OR = 1.8, p = .017). YACCS reported more impact on scales representing a positive rather than negative impact of CC. Various domains of impact of childhood cancer were related to psychosocial outcomes, especially “Life Challenges” (HRQOL β = − .18, anxiety β = .36, depression β = .29) and “Body & Health” (HRQOL β = .27, anxiety β = − .25, depression β = − .26, fatigue β = − .47). Conclusion YACCS are vulnerable to psychosocial difficulties, but they also experience positive long-term impacts of childhood cancer. Positive and negative impacts of childhood cancer were associated with psychosocial outcomes in YACCS. Screening of psychosocial outcomes and offering targeted interventions are necessary to optimize psychosocial long-term follow-up care for YACCS.

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Long-Term Psychosocial Well-Being and Quality of Life Among Childhood Cancer Survivors Who Developed a Subsequent Malignant Neoplasm

Journal of Adolescent and Young Adult Oncology ◽

10.1089/jayao.2020.0046 ◽

2020 ◽

Author(s):

Donghao Lu ◽

Lisa B. Kenney ◽

Lynda M. Vrooman ◽

Christopher J. Recklitis

Keyword(s):

Quality Of Life ◽

Cancer Survivors ◽

Childhood Cancer ◽

Malignant Neoplasm ◽

Well Being ◽

Childhood Cancer Survivors

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Psychosocial Impairment and Lower Quality of Life among Childhood Cancer Survivors in Egypt, Single Institution Experince.

Blood ◽

10.1182/blood.v108.11.5528.5528 ◽

2006 ◽

Vol 108 (11) ◽

pp. 5528-5528

Author(s):

Mona Elsamahy ◽

Ashraf Abdelmonem ◽

Shahinda Abdelrahman

Keyword(s):

Quality Of Life ◽

Cancer Therapy ◽

Cancer Survivors ◽

Childhood Cancer ◽

Child Behavior Checklist ◽

Well Being ◽

Childhood Cancer Survivors ◽

Self Report ◽

School Functioning

Abstract Survival itself has, until recently, been the marker of successful cancer therapy, but now more attention is being focused on the long-term effects of cancer therapy and the quality of life (QOL)of the survivors. OBJECTIVE: To assess health related quality of life and behavior and emotional problems among childhood cancer survivors at Ain Shams Pediatric Oncology Clinic, Cairo, Egypt. DESIGN: This study was conducted on 30 childhood cancer survivors attending the cancer survivors’ clinic at Ain Sham Children’s University Hospital in the period of October 2004–April 2005. The PedsQL™ 4.0 Generic Core Scales (physical, emotional, social and, school functioning) translated into Arabic language has been utilized. Parallel child self-report and parent proxy-report questionnaire formats have been used. Items were reverse-scored and linearly transformed to a 0–100 scale, so that higher scores indicate better QOL. Assessment of behavioral and emotional disturbance was performed using The Child Behavior Checklist (CBCL) Results: Age range 6–16 years with a mean age of 10.7±2.9 years, 18 (60%) were males and 12(40%) were females. Seventeen patients (56.6%) were acute leukemia survivors and 10(43.4%) lymphomas and solid tumors. There was statistically significant (p<0.001) decrease in the overall generic PedsQL in cancer survivors (mean 67±11.6) compared to normal children (mean 83.9±12.5) with school functioning area being the most affected (score 47.5±13). ALL survivors had significantly lower mean QOL (62.5±11.8) compared to other cancer survivors (72.8±8.8) (p<0.05). Gender (females) and CNS-directed therapy were risk factors for poorer QOL. Strong agreement between parents and their children QOL rating was seen in most of the QOL domains {overall QOL (p=0.001) physical well being (p=0.04), emotional feelings (p=0.0004), and social interaction (p=0.003) with the strongest correlation in the school domain (p=0.000004)}. Fifty three percent of the survivors showed clinical range of social incompetence with survivors who were diagnosed before the age of 3 were less socially competent than those who were diagnosed after this age (p<0.05), 63% expressed Internalizing behavioral problems and while 23% had Externalizing problems. CONCLUSION: This results demonstrate Chidhood cancer survivors are at significant risk of poor psychosocial functioning and QOL.

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Posttraumatic Stress Symptoms During Treatment in Parents of Children With Cancer

Journal of Clinical Oncology ◽

10.1200/jco.2005.09.110 ◽

2005 ◽

Vol 23 (30) ◽

pp. 7405-7410 ◽

Cited By ~ 167

Author(s):

Anne E. Kazak ◽

C. Alexandra Boeving ◽

Melissa A. Alderfer ◽

Wei-Ting Hwang ◽

Anne Reilly

Keyword(s):

Cancer Survivors ◽

Childhood Cancer ◽

Posttraumatic Stress ◽

Well Being ◽

Childhood Cancer Survivors ◽

Posttraumatic Stress Symptoms ◽

Treatment Intensity ◽

Mothers And Fathers ◽

Stress Symptoms ◽

Time Since Diagnosis

Purpose The conceptualization of childhood cancer and its treatment as traumatic has gained increasing support in the growing literature on medically related posttraumatic stress. Posttraumatic stress symptoms (PTSS) such as intrusive thoughts, physiologic arousal, and avoidance have been documented in mothers and fathers of childhood cancer survivors. In this study we investigated the presence of PTSS in parents of children currently in treatment and their association with treatment intensity and length of time since diagnosis. Methods Mothers (N = 119) and fathers (N = 52) of children currently in treatment for a childhood malignancy completed questionnaire measures of PTSS. Outcomes on these measures were compared with a sample of parents of childhood cancer survivors from our hospital. Oncologist ratings of treatment intensity were obtained based on diagnosis, treatment modalities, and protocol number. Results All but one parent reported PTSS. Mean scores indicated moderate PTSS for both mothers and fathers. In families with two participating parents, nearly 80% had at least one parent with moderate-to-severe PTSS. There were minimal associations between PTSS and length of time since diagnosis. Conclusion PTSS are common among parents of children currently undergoing cancer treatment. Trauma-informed psychosocial interventions can be used to help patients and families, including normalizing the experience as potentially traumatic and using evidence-based interventions that are emerging to facilitate long-term well-being.

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