scholarly journals Redox Isomerization of Allylic Alcohols Catalyzed by New Water-Soluble Rh(I)-N-Heterocyclic Carbene Complexes

Catalysts ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 1361
Author(s):  
Csilla Enikő Czégéni ◽  
Marianna Fekete ◽  
Eszter Tóbiás ◽  
Antal Udvardy ◽  
Henrietta Horváth ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Aqueous Phase ◽  
Aqueous Media ◽  
Water Soluble ◽  
Allylic Alcohols ◽  
Tertiary Phosphine ◽  
Carbene Complexes ◽  
Phosphine Complexes ◽  
First Time ◽  
Redox Isomerization

New water-soluble, N-heterocyclic carbene (NHC) or mixed NHC/tertiary phosphine complexes [RhCl(cod)(sSIMes)], Na2[Rh(bmim)(cod)(mtppts)], and [Rh(bmim)(cod)(pta)]BF4 were synthetized and applied for the first time as catalysts in redox isomerization of allylic alcohols in aqueous media. [RhCl(cod)(sSIMes)] (with added sulfonated triphenylphosphine) and [Rh(bmim)(cod)(pta)]BF4 catalyzed selectively the transformation of allylic alcohols to the corresponding ketones. The highest catalytic activity, TOF = 152 h−1 (TOF = (mol reacted substrate) × (mol catalyst × time)−1) was observed in redox isomerization of hept-1-en-3-ol ([S]/[cat] = 100). The catalysts were reused in the aqueous phase at least three times, with only modest loss of the catalytic activity and selectivity.

Quadrol-Pd(II) complexes: phosphine-free precatalysts for the room-temperature Suzuki-Miyaura synthesis of nucleoside analogues in aqueous media

2022 ◽  
Author(s):  
Jose Luis Serrano ◽  
Sujeet Gaware ◽  
Jose Antonio Pérez de Haro ◽  
Jose Pérez ◽  
Pedro Lozano ◽  
...  
Keyword(s):  
Room Temperature ◽  
Aqueous Media ◽  
Water Soluble ◽  
Nucleoside Analogues ◽  
Synthesis And Characterization ◽  
First Time

Commercially available Quadrol, N,N,N',N'-tetrakis(2-hydroxypropyl)ethylenediamine (THPEN), has been used for the first time as N^N- donor neutral hydrophilic ligand in the synthesis and characterization of new water soluble palladium (II) complexes...

Ruthenium-catalyzed redox isomerization/transfer hydrogenation in organic and aqueous media: A one-pot tandem process for the reduction of allylic alcohols

2009 ◽  
Vol 11 (12) ◽  
pp. 1992 ◽  
Author(s):  
Victorio Cadierno ◽  
Pascale Crochet ◽  
Javier Francos ◽  
Sergio E. García-Garrido ◽  
José Gimeno ◽  
...  
Keyword(s):  
Aqueous Media ◽  
Transfer Hydrogenation ◽  
Allylic Alcohols ◽  
One Pot ◽  
Tandem Process ◽  
Redox Isomerization

Hydrogenation and Redox Isomerization of Allylic Alcohols Catalyzed by a New Water-Soluble Pd–tetrahydrosalen Complex

2013 ◽  
Vol 32 (15) ◽  
pp. 4391-4401 ◽  
Author(s):  
Krisztina Voronova ◽  
Mihály Purgel ◽  
Antal Udvardy ◽  
Attila C. Bényei ◽  
Ágnes Kathó ◽  
...  
Keyword(s):  
Water Soluble ◽  
Allylic Alcohols ◽  
Redox Isomerization

ChemInform Abstract: Ruthenium-Catalyzed Redox Isomerization/Transfer Hydrogenation in Organic and Aqueous Media: A One-Pot Tandem Process for the Reduction of Allylic Alcohols.

ChemInform ◽  
2010 ◽  
Vol 41 (18) ◽  
Author(s):  
Victorio Cadierno ◽  
Pascale Crochet ◽  
Javier Francos ◽  
Sergio E. Garcia-Garrido ◽  
Jose Gimeno ◽  
...  
Keyword(s):  
Aqueous Media ◽  
Transfer Hydrogenation ◽  
Allylic Alcohols ◽  
One Pot ◽  
Tandem Process ◽  
Redox Isomerization

New Water-Soluble Iridium(I)–N-Heterocyclic Carbene–Tertiary Phosphine Mixed-Ligand Complexes as Catalysts of Hydrogenation and Redox Isomerization

2014 ◽  
Vol 33 (22) ◽  
pp. 6330-6340 ◽  
Author(s):  
Henrietta Horváth ◽  
Ágnes Kathó ◽  
Antal Udvardy ◽  
Gábor Papp ◽  
Dorina Szikszai ◽  
...  
Keyword(s):  
Mixed Ligand ◽  
Water Soluble ◽  
Mixed Ligand Complexes ◽  
Tertiary Phosphine ◽  
Redox Isomerization

scholarly journals Water Soluble Iron-Based Coordination Trimers as Synergistic Adjuvants for Pancreatic Cancer

Antioxidants ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 66
Author(s):  
Marco Cordani ◽  
Esther Resines-Urien ◽  
Arturo Gamonal ◽  
Paula Milán-Rois ◽  
Lionel Salmon ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Lines ◽  
Pancreatic Cancer Cell ◽  
Aqueous Media ◽  
Coordination Complexes ◽  
Water Soluble ◽  
Therapeutic Approaches ◽  
Iron Based ◽  
High Concentrations ◽  
First Time

Pancreatic cancer is a usually fatal disease that needs innovative therapeutic approaches since the current treatments are poorly effective. In this study, based on cell lines, triazole-based coordination trimers made with soluble Fe(II) in an aqueous media were explored for the first time as adjuvant agents for the treatment of this condition. These coordination complexes were effective at relatively high concentrations and led to an increase in reactive oxygen species (ROS) in two pancreatic cancer cell lines, PANC-1 and BXPC-3, and this effect was accompanied by a significant reduction in cell viability in the presence of gemcitabine (GEM). Importantly, the tested compounds enhanced the effect of GEM, an approved drug for pancreatic cancer, through apoptosis induction and downregulation of the mTOR pathway. Although further evaluation in animal-based models of pancreatic cancer is needed, these results open novel avenues for exploring these iron-based materials in biomedicine in general and in pancreatic cancer treatment.

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