scholarly journals Patterns of Gene Expression in Cutaneous T-Cell Lymphoma: Systematic Review of Transcriptomic Studies in Mycosis Fungoides

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1409
Author(s):  
Melika Motamedi ◽  
Maggie Z. X. Xiao ◽  
Aishwarya Iyer ◽  
Robert Gniadecki
Keyword(s):  
Systematic Review ◽  
Mycosis Fungoides ◽  
Chromosomal Instability ◽  
Cell Lymphoma ◽  
Immune Checkpoints ◽  
Cutaneous T Cell Lymphoma ◽  
Risk Of Mortality ◽  
Increased Risk ◽  
Transcriptomic Changes ◽  
Late Stages

Mycosis fungoides (MF) is the most prevalent type of skin lymphoma. In its early stages, it has a favorable prognosis. However, in its late stages, it is associated with an increased risk of mortality. This systematic review aimed to identify the transcriptomic changes involved in MF pathogenesis and progression. A literature search was conducted using the database PubMed, followed by the extraction of 2245 genes which were further filtered to 150 recurrent genes that appeared in two or more publications. Categorization of these genes identified activated pathways involved in pathways such as cell cycle and proliferation, chromosomal instability, and DNA repair. We identified 15 genes implicated in MF progression, which were involved in cell proliferation, immune checkpoints, resistance to apoptosis, and immune response. In highlighting the discrepancies in the way MF transcriptomic data is obtained, further research can focus on not only unifying their approach but also focus on the 150 pertinent genes identified in this review.

scholarly journals Atypical Presentation of Mycosis Fungoides- A Rare Case Report

2015 ◽  
Vol 4 (2) ◽  
pp. 62-64
Author(s):  
MA Wahab ◽  
Md Mahabubur Rahaman ◽  
Nehal Warish ◽  
Md Rezaul Quader ◽  
M Hasibur Rahman
Keyword(s):  
Case Report ◽  
Mycosis Fungoides ◽  
Rare Case ◽  
Cell Lymphoma ◽  
Atypical Presentation ◽  
Cutaneous T Cell Lymphoma ◽  
Papular Eruption ◽  
Clinical Stages ◽  
Rare Case Report ◽  
Late Stages

Commonest cutaneous T cell lymphoma is mycosis fungoides. Clinical stages are patch, plaque, tumor; erythroderma and poikoiloderma. Extracutaneous spread takes place in late stages where any organ may be involved. The majority of reported cases are with typical presentation. A rare case of mycosis fungoides in a 45-year-old male with papular eruption is described. CBMJ 2015 July: Vol. 04 No. 02 P: 62-64

scholarly journals Municipal Solid Waste Management and Adverse Health Outcomes: A Systematic Review

2021 ◽  
Vol 18 (8) ◽  
pp. 4331
Author(s):  
Giovanni Vinti ◽  
Valerie Bauza ◽  
Thomas Clasen ◽  
Kate Medlicott ◽  
Terry Tudor ◽  
...  
Keyword(s):  
Mental Health ◽  
Systematic Review ◽  
Municipal Solid Waste ◽  
Solid Waste ◽  
Health Effects ◽  
Neonatal Outcomes ◽  
Municipal Solid Waste Management ◽  
Open Burning ◽  
Risk Of Mortality ◽  
Increased Risk

Municipal solid waste (MSW) can pose a threat to public health if it is not safely managed. Despite prior research, uncertainties remain and refurbished evidence is needed along with new approaches. We conducted a systematic review of recently published literature to update and expand the epidemiological evidence on the association between MSW management practices and resident populations’ health risks. Studies published from January 2005 to January 2020 were searched and reviewed following PRISMA guidelines. Eligible MSW treatment or disposal sites were defined as landfills, dumpsites, incinerators, waste open burning, transfer stations, recycling sites, composting plants, and anaerobic digesters. Occupational risks were not assessed. Health effects investigated included mortality, adverse birth and neonatal outcomes, cancer, respiratory conditions, gastroenteritis, vector-borne diseases, mental health conditions, and cardiovascular diseases. Studies reporting on human biomonitoring for exposure were eligible as well. Twenty-nine studies were identified that met the inclusion criteria of our protocol, assessing health effects only associated with proximity to landfills, incinerators, and dumpsites/open burning sites. There was some evidence of an increased risk of adverse birth and neonatal outcomes for residents near each type of MSW site. There was also some evidence of an increased risk of mortality, respiratory diseases, and negative mental health effects associated with residing near landfills. Additionally, there was some evidence of increased risk of mortality associated with residing near incinerators. However, in many cases, the evidence was inadequate to establish a strong relationship between a specific exposure and outcomes, and the studies rarely assessed new generation technologies. Evidence gaps remain, and recommendations for future research are discussed.

scholarly journals Renin-angiotensin system blocker and outcomes of COVID-19: a systematic review and meta-analysis

Thorax ◽  
2021 ◽  
pp. thoraxjnl-2020-215322
Author(s):  
Hyun Woo Lee ◽  
Chang-Hwan Yoon ◽  
Eun Jin Jang ◽  
Chang-Hoon Lee
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Severe Disease ◽  
Renin Angiotensin System ◽  
Angiotensin Ii Receptor ◽  
Angiotensin System ◽  
Risk Of Mortality ◽  
Increased Risk ◽  
All Cause Mortality ◽  
Receptor Blockers

BackgroundThe association of ACE inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) with disease severity of patients with COVID-19 is still unclear. We conducted a systematic review and meta-analysis to investigate if ACEI/ARB use is associated with the risk of mortality and severe disease in patients with COVID-19.MethodsWe searched all available clinical studies that included patients with confirmed COVID-19 who could be classified into an ACEI/ARB group and a non-ACEI/ARB group up until 4 May 2020. A meta-analysis was performed, and primary outcomes were all-cause mortality and severe disease.ResultsACEI/ARB use did not increase the risk of all-cause mortality both in meta-analysis for 11 studies with 12 601 patients reporting ORs (OR=0.52 (95% CI=0.37 to 0.72), moderate certainty of evidence) and in 2 studies with 8577 patients presenting HRs. For 12 848 patients in 13 studies, ACEI/ARB use was not related to an increased risk of severe disease in COVID-19 (OR=0.68 (95% CI=0.44 to 1.07); I2=95%, low certainty of evidence).ConclusionsACEI/ARB therapy was not associated with increased risk of all-cause mortality or severe manifestations in patients with COVID-19. ACEI/ARB therapy can be continued without concern of drug-related worsening in patients with COVID-19.

scholarly journals PRO25 Healthcare Resource Use in Mycosis Fungoides-Type Cutaneous T-Cell Lymphoma: Results from a UK-Based Clinician Questionnaire

2020 ◽  
Vol 23 ◽  
pp. S693-S694
Author(s):  
J. Scarisbrick ◽  
F. Schmidt ◽  
M.M. Turini ◽  
P. D'agostino ◽  
D. Summers ◽  
...  
Keyword(s):  
T Cell ◽  
Mycosis Fungoides ◽  
Resource Use ◽  
Healthcare Resource ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Healthcare Resource Use

Cutaneous T-Cell Lymphoma: Mycosis Fungoides and Sézary Syndrome

2019 ◽  
pp. 221-246
Author(s):  
Timothy J. Voorhees ◽  
Edith V. Bowers ◽  
Christopher R. Kelsey ◽  
Yara Park ◽  
Anne W. Beaven
Keyword(s):  
T Cell ◽  
Mycosis Fungoides ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Sézary Syndrome ◽  
Sezary Syndrome ◽  
Cutaneous T Cell Lymphoma
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