Application of Gold Nanoparticle-Based Materials in Cancer Therapy and Diagnostics

Several metal nanoparticles have been developed for medical application. While all have their benefits, gold nanoparticles (AuNPs) are ideal in cancer therapy and diagnosis as they are chemically inert and minimally toxic. Several studies have shown the potential of AuNPs in the therapeutic field, as photosensitizing agents in sonochemical and photothermal therapy and as drug delivery, as well as in diagnostics and theranostics. Although there is a significant number of reviews on the application of AuNPs in cancer medicine, there is no comprehensive review on their application both in therapy and diagnostics. Therefore, considering the high number of studies on AuNPs’ applications, this review summarizes data on the application of AuNPs in cancer therapy and diagnostics. In addition, we looked at the influence of AuNPs’ shape and size on their biological properties. We also present the potential use of hybrid materials based on AuNPs in sonochemical and photothermal therapy and the possibility of their use in diagnostics. Despite their potential, the use of AuNPs and derivatives in cancer medicine still has some limitations. In this review, we provide an overview of the biological, physicochemical, and legal constraints on using AuNPs in cancer medicine.

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99mTc-, 90Y-, and 177Lu-Labeled Iron Oxide Nanoflowers Designed for Potential Use in Dual Magnetic Hyperthermia/Radionuclide Cancer Therapy and Diagnosis

ACS Applied Materials & Interfaces ◽

10.1021/acsami.9b16428 ◽

2019 ◽

Vol 11 (44) ◽

pp. 41109-41117 ◽

Cited By ~ 8

Author(s):

Miloš Ognjanović ◽

Magdalena Radović ◽

Marija Mirković ◽

Željko Prijović ◽

Maria del Puerto Morales ◽

...

Keyword(s):

Iron Oxide ◽

Cancer Therapy ◽

Magnetic Hyperthermia ◽

Therapy And Diagnosis ◽

Potential Use

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Iron in parasitic protists – from uptake to storage and where we can interfere

Metallomics ◽

10.1039/d0mt00125b ◽

2020 ◽

Vol 12 (9) ◽

pp. 1335-1347

Author(s):

Jan Mach ◽

Robert Sutak

Keyword(s):

Iron Metabolism ◽

Drug Target ◽

Comprehensive Review ◽

Potential Use

A comprehensive review of iron metabolism in parasitic protists and its potential use as a drug target.

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Comparative radium-223 labeling with NOTA and DOTA-somatostatin derivatives for a potential use in targeted cancer therapy

Nuclear Medicine and Biology ◽

10.1016/s0969-8051(19)30328-2 ◽

2019 ◽

Vol 72-73 ◽

pp. S50-S51

Author(s):

M. Riondato ◽

S. Pastorino ◽

V. Duce ◽

E. Giovannini ◽

A. Ciarmiello

Keyword(s):

Cancer Therapy ◽

Targeted Cancer Therapy ◽

Radium 223 ◽

Potential Use

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Bi19S27I3 nanorods: a new candidate for photothermal therapy in the first and second biological near-infrared windows

Nanoscale ◽

10.1039/d0nr09137e ◽

2021 ◽

Author(s):

Jinsong Xiong ◽

Qinghuan Bian ◽

Shuijin Lei ◽

Yatian Deng ◽

Kehan Zhao ◽

...

Keyword(s):

Cancer Therapy ◽

Photothermal Therapy ◽

Near Infrared ◽

Research Interest ◽

The Past ◽

Nir Light ◽

Considerable Research ◽

Key Factor

Near-infrared (NIR) light induced photothermal cancer therapy using nanomaterials as photothermal agents has attracted considerable research interest over the past few years. As the key factor in the photothermal therapy...

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Coconut-shell-derived activated carbon for NIR photo-activated synergistic photothermal-chemodynamic cancer therapy

Journal of Materials Chemistry B ◽

10.1039/d0tb02782k ◽

2021 ◽

Author(s):

Gang Wu ◽

Bao Jiang ◽

Lin Zhou ◽

Ao Wang ◽

Shaohua Wei

Keyword(s):

Activated Carbon ◽

Cancer Therapy ◽

Cancer Treatment ◽

Photothermal Therapy ◽

Carbon Nanoparticles ◽

Coconut Shell ◽

Photothermal Conversion

Activated carbon nanoparticles (ANs) were synthesized from coconut shell. ANs show peroxidase and photothermal conversion activities, allowing synergistic cancer treatment via chemodynamic therapy (CDT) and photothermal therapy (PTT).

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Boosting Chemodynamic Therapy by the Synergistic Effect of Co-Catalyze and Photothermal Effect Triggered by the Second Near-Infrared Light

Nano-Micro Letters ◽

10.1007/s40820-020-00516-z ◽

2020 ◽

Vol 12 (1) ◽

Author(s):

Songtao Zhang ◽

Longhai Jin ◽

Jianhua Liu ◽

Yang Liu ◽

Tianqi Zhang ◽

...

Keyword(s):

Cancer Therapy ◽

Bovine Serum Albumin ◽

Synergistic Effect ◽

Bovine Serum ◽

Photothermal Therapy ◽

Near Infrared ◽

Infrared Light ◽

Photothermal Effect ◽

Reaction Efficiency

AbstractIn spite of the tumor microenvironments responsive cancer therapy based on Fenton reaction (i.e., chemodynamic therapy, CDT) has been attracted more attentions in recent years, the limited Fenton reaction efficiency is the important obstacle to further application in clinic. Herein, we synthesized novel FeO/MoS2 nanocomposites modified by bovine serum albumin (FeO/MoS2-BSA) with boosted Fenton reaction efficiency by the synergistic effect of co-catalyze and photothermal effect of MoS2 nanosheets triggered by the second near-infrared (NIR II) light. In the tumor microenvironments, the MoS2 nanosheets not only can accelerate the conversion of Fe3+ ions to Fe2+ ions by Mo4+ ions on their surface to improve Fenton reaction efficiency, but also endow FeO/MoS2-BSA with good photothermal performances for photothermal-enhanced CDT and photothermal therapy (PTT). Consequently, benefiting from the synergetic-enhanced CDT/PTT, the tumors are eradicated completely in vivo. This work provides innovative synergistic strategy for constructing nanocomposites for highly efficient CDT.

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Bile Acid Conjugates with Anticancer Activity: Most Recent Research

Molecules ◽

10.3390/molecules26010025 ◽

2020 ◽

Vol 26 (1) ◽

pp. 25

Author(s):

Maria Luisa Navacchia ◽

Elena Marchesi ◽

Daniela Perrone

Keyword(s):

Bile Acid ◽

Cancer Therapy ◽

Anticancer Activity ◽

Bile Acids ◽

Treatment Modality ◽

Biological Properties ◽

Therapeutic Agents ◽

Bioactive Molecules ◽

Hybrid Functional ◽

Hybrid Molecules

The advantages of a treatment modality that combines two or more therapeutic agents in cancer therapy encourages the study of hybrid functional compounds for pharmacological applications. In light of this, we reviewed recent works on hybrid molecules based on bile acids. Due to their biological properties, as well as their different chemical/biochemical reactive moieties, bile acids can be considered very interesting starting molecules for conjugation with natural or synthetic bioactive molecules.

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