Functionalization of Bulk SiO2 Surface with Biomolecules for Sensing Applications: Structural and Functional Characterizations

Biomolecule immobilization on bulk silicon dioxide (SiO2) is an important aspect in the field of Si-based interfaces for biosensing. The approach used for surface preparation should guarantee not only the stable anchoring of biomolecules but also their structural integrity and biological functioning. In this paper, we review our findings on the SiO2 functionalization process to immobilize a variety of biomolecules, including glucose oxidase, horseradish peroxide, metallothionein, and DNA molecules. Morphological and chemical characterization of SiO2 surfaces after biomolecule immobilization using techniques already employed in the microelectronic industry are presented and discussed. Optical and spectrophotometric analysis revealed the preservation of biomolecules’ activity once they are anchored on the biointerface.

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Physico-chemical Characterization of Thin Oxide Films: Difficulties and Solutions

MRS Proceedings ◽

10.1557/proc-1073-h05-01 ◽

2008 ◽

Vol 1073 ◽

Author(s):

Thierry Conard ◽

Wilfried Vandervorst

Keyword(s):

Substrate Surface ◽

Depth Profiling ◽

Chemical Characterization ◽

Surface Preparation ◽

High Energy ◽

Thin Layers ◽

Back Side ◽

Gate Stack ◽

Metal Gates

ABSTRACTOxides have always been an integral part of semiconductor manufacturing both in front and back-end processing. With the necessary increase in performance, the demand on these oxides has been increasing leading to their (future) replacement by more complex materials, such as high-k's in gate oxide and metal gates. With the increasing material complexity, a thorough characterization of all aspects of these materials is necessary, covering, for instance, surfaces and interfaces, nucleation, growth, atomic structure, …This article focuses on the characterization of front-end oxides and their interfaces. It shows that detailed information can be achieved by sophisticated experimental techniques such as synchrotron radiation, high energy ERD or AtomProbe but that adequate sample preparation and/or analysis by a combination of more routinely available techniques may achieve similar results. This is shown through the study of three different systems/problems in the gate stack analysis. We will first focus on the determination of substrate surface preparation conditions before deposition and their influence on growth mode and the growth characteristics by different growth techniques (ALD, MOCVD, …). Second, we present the possibilities of compositional depth profiling of thin layers both with nuclear techniques and Angle-Resolved XPS. Finally, we will show that using conventional XPS and a combination of front and back-side analysis, the interface between high-k oxide and metal gates can be investigated. More examples of gate stack characterization can be found elsewhere

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Optical and chemical characterization of expanding thermal plasma-deposited carbon-containing silicon dioxide-like films

Thin Solid Films ◽

10.1016/j.tsf.2008.05.022 ◽

2008 ◽

Vol 516 (23) ◽

pp. 8547-8553 ◽

Cited By ~ 20

Author(s):

M. Creatore ◽

S.M. Rieter ◽

Y. Barrell ◽

M.C.M. van de Sanden ◽

R. Vernhes ◽

...

Keyword(s):

Silicon Dioxide ◽

Thermal Plasma ◽

Chemical Characterization

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Optical and chemical characterization of expanding thermal plasma deposited silicon dioxide-like films

Thin Solid Films ◽

10.1016/j.tsf.2005.02.015 ◽

2005 ◽

Vol 484 (1-2) ◽

pp. 104-112 ◽

Cited By ~ 27

Author(s):

M. Creatore ◽

J.-C. Cigal ◽

G.M.W. Kroesen ◽

M.C.M. van de Sanden

Keyword(s):

Silicon Dioxide ◽

Thermal Plasma ◽

Chemical Characterization

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Olfactory and Chemical Characterization of Indoor Air-Towards a Psychophysical Model for Air Quality

PsycEXTRA Dataset ◽

10.1037/e612282010-001 ◽

1981 ◽

Author(s):

Birgitta Berglund ◽

Ulf Berglund ◽

Thomas Lindvall ◽

Helene Nicander-Bredberg

Keyword(s):

Air Quality ◽

Indoor Air ◽

Chemical Characterization

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The physical and chemical characterization of active carbons, by adsorption and immersion techniques

Journal de Chimie Physique ◽

10.1051/jcp/1984810785 ◽

1984 ◽

Vol 81 ◽

pp. 785-790 ◽

Cited By ~ 9

Author(s):

F. Stoeckli ◽

F. Kraehenbuehl ◽

A. Lavanchy ◽

U. Huber

Keyword(s):

Chemical Characterization ◽

Active Carbons ◽

Physical And Chemical Characterization ◽

Physical And Chemical

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Biological and physico-chemical characterization of ultra high diluted Hydrastis canadensis and in vitro studies on mammalian cells

Allgemeine Homöopathische Zeitung ◽

10.1055/s-0037-1601241 ◽

2017 ◽

Vol 262 (02) ◽

pp. 2-76

Author(s):

N Chandrakar ◽

MK Temgire ◽

SG Kane ◽

AK Suresh ◽

J Bellare

Keyword(s):

Mammalian Cells ◽

Chemical Characterization ◽

In Vitro Studies ◽

Hydrastis Canadensis ◽

Physico Chemical

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PURIFICATION AND PARTIAL CHEMICAL CHARACTERIZATION OF SHEEP NEUROPHYSIN

Acta Endocrinologica ◽

10.1530/acta.0.0740226 ◽

1973 ◽

Vol 74 (2) ◽

pp. 226-236 ◽

Cited By ~ 6

Author(s):

Michel Chrétien ◽

Claude Gilardeau

Keyword(s):

Amino Acid ◽

Polyacrylamide Gel Electrophoresis ◽

Chemical Characterization ◽

Terminal Amino Acid ◽

Amino Acid Determination ◽

Pituitary Glands ◽

Terminal Amino ◽

Partial Chemical ◽

Acid Determination

ABSTRACT A protein isolated from ovine pituitary glands has been purified, and its homogeneity assessed by NH2- and COOH-terminal amino acid determination, ultracentrifugation studies, and polyacrylamide gel electrophoresis after carboxymethylation. Its chemical and immunochemical properties are closely similar to those of beef and pork neurophysins, less similar to those of human neurophysins. It contains no tryptophan (like other neurophysins) or histidine (like all except bovine neurophysin-I and human neurophysins). It has alanine at the NH2-terminus and valine at the COOH-terminus. Its amino acid composition is similar to, but not identical with those of porcine and bovine neurophysins.

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