scholarly journals Head Growth and Neurodevelopment of Preterm Infants with Surgical Necrotizing Enterocolitis and Spontaneous Intestinal Perforation

Children ◽  
2021 ◽  
Vol 8 (10) ◽  
pp. 833
Author(s):  
Seung-Han Shin ◽  
Ee-Kyung Kim ◽  
Seh-Hyun Kim ◽  
Hyun-Young Kim ◽  
Han-Suk Kim
Keyword(s):  
Preterm Infants ◽  
Necrotizing Enterocolitis ◽  
Intestinal Perforation ◽  
Fine Motor ◽  
Neurodevelopmental Outcomes ◽  
Head Growth ◽  
Single Center Study ◽  
Ages And Stages Questionnaire ◽  
Bayley Scales ◽  
Spontaneous Intestinal Perforation

Spontaneous intestinal perforation (SIP) and surgical necrotizing enterocolitis (NEC) are intestinal conditions requiring surgical intervention in preterm infants. We aimed to compare the head growth and neurodevelopment of preterm infants with SIP and surgical NEC. A retrospective single-center study was performed in preterm infants born at less than 32 weeks of gestation and who had undergone surgery for NEC or SIP. Data from the Bayley Scales of Infant and Toddler Development 3rd Edition (Bayley-III) at 24 months of corrected age (CA) and the Korean Ages and Stages Questionnaire (K-ASQ) or Korean Developmental Screening Test (K-DST) at 36 months were collected. Among 82 eligible infants, 60 infants had surgical NEC, and 22 infants were diagnosed with SIP. Head growth was faster until CA 4 months in preterm infants with SIP than in those with surgical NEC. At 36 months, abnormal findings in the K-ASQ or K-DST were more prevalent in the NEC group than in the SIP group in the gross motor (48.2% vs. 0%, p = 0.015), fine motor (40.7% vs. 0%, p = 0.037), cognitive (55.6% vs. 12.5%, p = 0.047), and social domains (44.4% vs. 0%, p = 0.032). More studies evaluating the neurodevelopmental outcomes of preterm infants with surgical NEC and SIP are required.

Antenatal Exposure to Magnesium Sulfate and Spontaneous Intestinal Perforation and Necrotizing Enterocolitis in Extremely Preterm Neonates

2017 ◽  
Vol 34 (12) ◽  
pp. 1227-1233 ◽  
Author(s):  
Mohamed Shalabi ◽  
Adel Mohamed ◽  
Brigitte Lemyre ◽  
Khalid Aziz ◽  
Daniel Faucher ◽  
...  
Keyword(s):  
Magnesium Sulfate ◽  
Preterm Infants ◽  
Necrotizing Enterocolitis ◽  
Intestinal Perforation ◽  
Preterm Neonates ◽  
Network Database ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
Using Data ◽  
Spontaneous Intestinal Perforation

Background There have been recent concerns regarding the higher rates of spontaneous intestinal perforation (SIP) in preterm infants that have been exposed to intrapartum magnesium sulfate (MgSO4). Objective To assess the association between intrapartum MgSO4 exposure and necrotizing enterocolitis (NEC) and/or SIP in extremely preterm neonates. Design A retrospective cohort study was conducted using data from the Canadian Neonatal Network database. Infants born at < 28 weeks' gestation admitted to neonatal units in Canada between 2011 and 2014 were divided into two groups: those exposed antenatally to MgSO4 and those unexposed. Stratified analyses for infants born between 22 and 25 weeks' gestation and those born between 26 and 27 weeks' gestation were conducted. The primary outcome was intestinal injury, identified as either NEC or SIP. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were calculated using multivariable logistic regression. Results We compared 2,300 unexposed infants with 2,055 exposed infants. There was no difference in the odds of NEC (9.88% exposed vs. 9.59% unexposed; aOR: 0.92; 95% CI: 0.75–1.14) or SIP (3.4% exposed vs. 3.39% unexposed; aOR: 1.05; 95% CI: 0.75–1.48) between the two groups. Conclusion Antenatal exposure to MgSO4 was not associated with NEC or SIP in extremely preterm infants.

scholarly journals Immunoregulatory Protein Profiles of Necrotizing Enterocolitis versus Spontaneous Intestinal Perforation in Preterm Infants

PLoS ONE ◽  
2012 ◽  
Vol 7 (5) ◽  
pp. e36977 ◽  
Author(s):  
Kathy Yuen Yee Chan ◽  
Fiona Wan Lun Leung ◽  
Hugh Simon Lam ◽  
Yuk Him Tam ◽  
Ka Fai To ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Necrotizing Enterocolitis ◽  
Intestinal Perforation ◽  
Protein Profiles ◽  
Spontaneous Intestinal Perforation

Analysis of Disialyllacto-N-Tetraose (DSLNT) Content in Milk From Mothers of Preterm Infants

2020 ◽  
Vol 36 (2) ◽  
pp. 291-298 ◽  
Author(s):  
Denise Hassinger ◽  
Dana M. Clausen ◽  
Sarah Nitka ◽  
Aimee Herdt ◽  
Ian Griffin
Keyword(s):  
Human Milk ◽  
Preterm Infants ◽  
Necrotizing Enterocolitis ◽  
Intestinal Perforation ◽  
Protective Effects ◽  
Human Donor ◽  
Donor Milk ◽  
Mothers Of Preterm Infants ◽  
High Risk Infants ◽  
Spontaneous Intestinal Perforation

Background Human milk oligosaccharides (HMO) have been recognized for the protective effects they may elicit among high risk infants. One HMO, disialyllacto-N-tetraose (DSLNT), has been shown to reduce the risk for developing necrotizing enterocolitis in preterm infants. Research aims To measure DSLNT content in the human milk from mothers of preterm infants, and (1) assess variability; (2) establish correlations between maternal factors and/or an infant’s risk for developing necrotizing enterocolitis; and (3) determine the effect of pasteurization. Methods DSLNT was measured in 84 samples of preterm milk, in human donor milk, and in Holder and flash pasteurized samples. Preterm infant outcomes were assessed by medical record review. Results DSLNT content of mother’s own milk was highly variable and decreased significantly with increasing postnatal age. Four preterm infants (6.7%) developed necrotizing enterocolitis (Bell stage II or greater), 4 (6.7%) developed spontaneous intestinal perforation, and 1 developed both. DSLNT z-score was below the age-specific M within 8 (89%) of the 9 milk samples from mothers whose babies developed necrotizing enterocolitis ( p = 0.039), but the DSLNT content did not differ between infants with necrotizing enterocolitis, spontaneous intestinal perforation, or neither condition ( p > 0.1). DSLNT levels were significantly reduced in samples of donor milk compared to mothers’ own milk ( p = 0.0051). Pasteurization did not significantly reduce DSLNT content. Conclusions DSLNT content of human milk is variable and may be lower in milk from mothers whose infants developed necrotizing enterocolitis. DSLNT content is unaffected by flash or Holder pasteurization.

Antenatal Risk Factors Associated with Spontaneous Intestinal Perforation in Preterm Infants Receiving Postnatal Indomethacin

2021 ◽  
Author(s):  
Tamara I. Arnautovic ◽  
Jami L. Longo ◽  
Elizabeth J. Trail-Burns ◽  
Richard Tucker ◽  
Martin Keszler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preterm Infants ◽  
Intestinal Perforation ◽  
Factors Associated ◽  
Spontaneous Intestinal Perforation

Localized Intestinal Perforation

PEDIATRICS ◽  
1994 ◽  
Vol 94 (5) ◽  
pp. 776-776
Author(s):  
T. G. The' ◽  
M. Young ◽  
S. Rosser
Keyword(s):  
Preterm Infants ◽  
Necrotizing Enterocolitis ◽  
Intestinal Perforation ◽  
Umbilical Artery ◽  
Clinical Findings ◽  
Gastrointestinal Perforation

We read with pleasure Buchheit's1 article comparing the clinical findings in 21 preterm infants with localized intestinal perforation (LP) versus those of 21 preterm infants with intestinal perforation secondary to necrotizing enterocolitis (NEC). However, we would be grateful if the authors would clarify two points: 1. How are their 21 cases of LP different from the &gt;500 cases of idiopathic gastrointestinal perforation reviewed by Lloyd in 1979?2 2. The authors hypothesized that the placement of midthoracic umbilical artery catheters (UACs) would be a significant factor in the etiology of LP.

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