scholarly journals Role of Melatonin in Bone Remodeling Around Titanium Dental Implants: Meta-Analysis

Coatings ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 271
Author(s):  
Nansi López-Valverde ◽  
Beatriz Pardal-Peláez ◽  
Antonio López-Valverde ◽  
Juan Manuel Ramírez
Keyword(s):  
Nervous System ◽  
Bone Loss ◽  
Bone Remodeling ◽  
Random Effects ◽  
Meta Analysis ◽  
Titanium Implants ◽  
Crestal Bone Loss ◽  
Bone To Implant Contact ◽  
Titanium Dental Implants

The theory, known as the “brain-bone axis” theory, involves the central nervous system in bone remodeling. The alteration of the nervous system could lead to abnormal bone remodeling. Melatonin produced by the pineal gland is a hormone that is characterized by its antioxidant properties. The aim of this meta-analysis was to examine the role of melatonin in the growth of new bone around titanium dental implants in vivo. A manual search of the PubMed and Web of Science databases was conducted to identify scientific studies published until November 2020. We included randomized clinical trials (RCTs) and animal studies where melatonin was used with titanium implants. Fourteen studies met the inclusion criteria. Quality was assessed using the Jadad scale and SYRCLE's risk of bias tool. Our meta-analysis revealed that the use of melatonin during implant placement improves bone-to-implant contact percentages in animals (difference of means, random effects: 9.59 [95% CI: 5.53−13.65]), reducing crestal bone loss in humans (difference in means, random effects: -0.55 [95% CI: 1.10–0.00]). In animals, titanium implants using melatonin increase bone-to-implant contact surface 2−6 weeks after their placement and reduce crestal bone loss in humans following six months. The results of this meta-analysis should be taken with caution, due to the small samples and the large heterogeneity among studies.

scholarly journals Marginal Bone Loss and Aesthetics Around Zirconia and Titanium Dental Implants-A Metanalysis

2020 ◽  
Author(s):  
Pulijala Sathwika ◽  
Rampalli Viswa Chandra
Keyword(s):  
Bone Loss ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Titanium Implants ◽  
Controlled Trials ◽  
Marginal Bone Loss ◽  
Randomized Controlled ◽  
Cie Lab ◽  
Titanium Dental Implants ◽  
Zirconia Implants

AIM: To evaluate and compare the marginal bone loss and aesthetic outcomes of zirconia implants with titanium implants in randomized controlled trials (RCTs). MATERIAL AND METHODS: Electronic [PubMed] and hand searches were performed to identify randomized controlled trials that were published between January 2008 to April 2020 which investigated and compared various outcomes between zirconia and titanium dental implants. Outcomes included assessment of marginal bone loss and aesthetics using spectrophotometric measurements. Meta-analysis was performed to estimate the above parameters among various studies. RESULTS: A total of 58 articles were screened for titles and abstracts. Subsequently 8 articles were selected for data extraction and evaluation. Zirconia implants were investigated and compared to titanium implants for marginal bone loss [MBL]. Customized zirconia and titanium abutments seated over implants were analyzed for aesthetic outcomes using spectrophotometric method using CIE-Lab measurements. Meta-analysis estimated that zirconia implants exhibited marginal bone loss reduction of 0.179mm (95% CI, 0.02 to 0.33) and -0.242mm (95% CI, -4.026 to 3.542) in aesthetic measurements than titanium implants. CONCLUSIONS: No heterogeneity was observed among studies analyzed for marginal bone loss and significant differences were noticed between two groups. Noticeable heterogeneity was observed among studies assessing aesthetics using spectrophotometry and CIE-Lab measurements and results revealed no many significant differences between the two groups.

scholarly journals Effect of Zirconia Dental Implant Surfaces on Bone Integration: A Systematic Review and Meta-Analysis

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Ali Hafezeqoran ◽  
Roodabeh Koodaryan
Keyword(s):  
Systematic Review ◽  
Dental Implants ◽  
Meta Analysis ◽  
Titanium Implants ◽  
Removal Torque ◽  
Significant Difference ◽  
Modified Surface ◽  
Bone To Implant Contact ◽  
Titanium Dental Implants ◽  
Zirconia Implants

Background. The information available about osseointegration and the bone to implant interaction of zirconia implants with various surface modifications is still far from sufficient.Objective. The purpose of this systematic review and meta-analysis was to evaluate and compare zirconia dental implants with different surface topographies, with a focus on bone to implant contact and removal torque.Methods. The systematic review of the extracted publications was performed to compare the bone to implant contact (BIC) with removal torque (RT) values of titanium dental implants and machined and surfaced modified zirconia implants.Results. A total of fifteen articles on BIC and RT values were included in the quantitative analysis. No significant difference in the BIC values was observed between titanium and machined zirconia implants (p=0.373; 95% CI:-0.166 to 0.443). However, a significantly better BIC values were observed for acid etched zirconia implants compared with those of titanium implants (p=0.032; 95% CI: 0.068 to 1.461). Unmodified zirconia implants showed favorable BIC values compared to modified-surface zirconia implants (p=0.021; 95% CI:-0.973 to-0.080).Conclusion. Acid etched zirconia implants may serve as a possible substitute for successful osseointegration.

Survival of Short and Ultra-Short Locking-Taper Implants Supporting Single Crowns in the Posterior Mandible: A 3-Year Retrospective Study

2020 ◽  
Vol 46 (4) ◽  
pp. 396-406 ◽  
Author(s):  
Giorgio Lombardo ◽  
Annarita Signoriello ◽  
Miguel Simancas-Pallares ◽  
Mauro Marincola ◽  
Pier Francesco Nocini
Keyword(s):  
Retrospective Study ◽  
Bone Loss ◽  
Contact Point ◽  
Implant Survival ◽  
Point Position ◽  
Crestal Bone Loss ◽  
Short Implants ◽  
Single Crown ◽  
Bone To Implant Contact ◽  
Single Crowns

The purpose of this retrospective study was to determine survival and peri-implant marginal bone loss of short and ultra-short implants placed in the posterior mandible. A total of 98 patients received 201 locking-taper implants between January 2014 and January 2015. Implants were placed with a 2-stage approach and restored with single crowns. Clinical and radiographic examinations were performed at 3-year recall appointments. At that time, the proportion of implant survival by length, and variations of crestal bone levels (mean crestal bone loss and mean apical shift of the “first bone-to-implant contact point” position) were assessed. Significance level was set at 0.05. The total number of implants examined 36 months after loading included: 71 implants, 8.0 mm in length; 82 implants, 6.0 mm in length; and 48 implants, 5.0 mm in length. Five implants failed. The overall proportion of survival was 97.51%, with 98.59% for the 8.0-mm implants, 97.56% for the 6.0-mm implants, and 95.83% for the 5.0-mm implants. No statistically significant differences were found among the groups regarding implant survival (P = .73), mean crestal bone loss (P = .31), or mean apical shift of the “first bone-to-implant contact point” position (P = .36). Single-crown short and ultra-short implants may offer predictable outcomes in the atrophic posterior mandibular regions, though further investigations with longer follow-up evaluations are necessary to validate our results.

scholarly journals Direct Metal Laser Sintering Titanium Dental Implants: A Review of the Current Literature

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
F. Mangano ◽  
L. Chambrone ◽  
R. van Noort ◽  
C. Miller ◽  
P. Hatton ◽  
...  
Keyword(s):  
Dental Implants ◽  
Methodological Quality ◽  
Meta Analysis ◽  
Three Dimensional ◽  
Laser Sintering ◽  
Titanium Implants ◽  
Human Studies ◽  
Direct Metal Laser Sintering ◽  
Titanium Dental Implants

Statement of Problem. Direct metal laser sintering (DMLS) is a technology that allows fabrication of complex-shaped objects from powder-based materials, according to a three-dimensional (3D) computer model. With DMLS, it is possible to fabricate titanium dental implants with an inherently porous surface, a key property required of implantation devices.Objective. The aim of this review was to evaluate the evidence for the reliability of DMLS titanium dental implants and their clinical and histologic/histomorphometric outcomes, as well as their mechanical properties.Materials and Methods. Electronic database searches were performed. Inclusion criteria were clinical and radiographic studies, histologic/histomorphometric studies in humans and animals, mechanical evaluations, andin vitrocell culture studies on DMLS titanium implants. Meta-analysis could be performed only for randomized controlled trials (RCTs); to evaluate the methodological quality of observational human studies, the Newcastle-Ottawa scale (NOS) was used.Results. Twenty-seven studies were included in this review. No RCTs were found, and meta-analysis could not be performed. The outcomes of observational human studies were assessed using the NOS: these studies showed medium methodological quality.Conclusions. Several studies have demonstrated the potential for the use of DMLS titanium implants. However, further studies that demonstrate the benefits of DMLS implants over conventional implants are needed.

Novel hybrid drilling protocol: evaluation for the implant healing - thermal changes, crestal bone loss, and bone-to-implant contact

2014 ◽  
Vol 26 (7) ◽  
pp. 753-760 ◽  
Author(s):  
José Luis Calvo-Guirado ◽  
Jorge Delgado-Peña ◽  
Jose E. Maté-Sánchez ◽  
Javier Mareque Bueno ◽  
Rafael Arcesio Delgado-Ruiz ◽  
...  
Keyword(s):  
Bone Loss ◽  
Crestal Bone Loss ◽  
Thermal Changes ◽  
Bone To Implant Contact ◽  
Protocol Evaluation

Histomorphometric Evaluation of Bone Response to Different Titanium Implant Surfaces

2007 ◽  
Vol 361-363 ◽  
pp. 613-616
Author(s):  
Laurent Le Guenhennec ◽  
Eric Goyenvalle ◽  
Marco A. Lopez-Heredia ◽  
Pierre Weiss ◽  
Yves Amouriq ◽  
...  
Keyword(s):  
Dental Implants ◽  
Calcium Phosphates ◽  
Titanium Implant ◽  
Titanium Implants ◽  
Bone Response ◽  
Bone To Implant Contact ◽  
Coated Surfaces ◽  
Titanium Dental Implants

Titanium dental implants presenting different blasted surfaces and an OCP coated surfaces have been implanted in the femoral epiphysis of rabbits. A comparable osseointegration has been observed for the titanium implants blasted either with alumina or biphasic calcium phosphates particles whatever the delay of implantation (2 or 8 weeks). A higher bone to implant contact has been observed for the SLA and OCP coated implants as compared to the grit-blasted groups.

scholarly journals P.063 Endovascular Treatment of Acute Ischemic Stroke in Patients with Pre-morbid Disability: A Meta-analysis

2021 ◽  
Vol 48 (s3) ◽  
pp. S37-S37
Author(s):  
F Bala ◽  
B Beland ◽  
A Ganesh
Keyword(s):  
Ischemic Stroke ◽  
Endovascular Treatment ◽  
Random Effects ◽  
Observational Studies ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Endovascular Thrombectomy ◽  
Randomized Controlled ◽  
Stroke Disability

Background: Practice-changing trials of endovascular thrombectomy (EVT) for acute stroke excluded patients with pre-morbid disability. Observational studies may inform the role of EVT in this population. We performed a meta-analysis to estimate the effect of EVT in patients with pre-morbid disability. Methods: We adhered to PRISMA guidelines and searched Medline and Embase for studies describing EVT in adults with and without pre-morbid disability with stroke. Random-effects meta-analysis was used to pool outcomes, including favorable outcomes (mRS=0-2 or return to baseline), no increase in disability at 90 days, symptomatic ICH (sICH) and 90-day mortality. Results: We included 8 studies with 5570 patients (mRS 3-5=863, mRS 0-2=4,707). Patients with pre-morbid disability were more likely to return to their baseline mRS (aOR 2.53, 95% CI=1.47-4.36), although they had higher 90-day mortality (aOR=2.21, 95% CI=1.66-2.93). aOR for favorable outcome (aOR=0.83, 95% CI=0.67-1.03) or sICH (aOR=1.07, 95% CI=0.74-1.54) was not significantly different between groups. Conclusions: Observational studies suggest that EVT is safe in patients with pre-stroke disability and may result in comparable return to pre-stroke status as in patients without such disability. These findings argue against the routine exclusion of patients with pre-morbid disability from EVT and merit validation with randomized controlled trials.

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