scholarly journals Clinical Perspective and Translational Oncology of Liquid Biopsy

Diagnostics ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 443 ◽  
Author(s):  
Diego Fernández-Lázaro ◽  
Juan Luis García Hernández ◽  
Alberto Caballero García ◽  
Aurora Caballero del Castillo ◽  
María Villaverde Hueso ◽  
...  
Keyword(s):  
Real Time ◽  
Liquid Biopsy ◽  
Clonal Evolution ◽  
Resistance Mechanism ◽  
Cancer Disease ◽  
Tumor Identification ◽  
Metastatic Relapse ◽  
Different Types ◽  
Therapy Stratification ◽  
New Treatments

The term liquid biopsy (LB) refers to the study of circulating tumor cells, circulating tumors nucleic acids free of cells or contained in exosomes, and information about platelets associated with tumors. LB can be performed in different biofluids and allows the limitations of tissue biopsy to be overcome offering possibilities of tumor identification reflecting in real time tumor heterogeneity. In addition, LB allows screening and early detection of cancer, real-time monitoring of therapy, stratification and therapeutic intervention, a therapeutic target and resistance mechanism, and a risk of metastatic relapse. Currently, LB has been shown to be effective for its application in different types of tumors including lung, colorectal, prostate, melanoma, breast and pancreatic cancer, by the determination and identification of biomarkers that with a high probability have the potential to change the way in which medical oncology could predict the course of the disease. These biomarkers make it possible to capture the heterogeneity of the cancer, monitor its clonal evolution, indicate new treatments or retreatments and evaluate the responses to different evolutionary and/or therapeutic pressures in the cancer disease.

scholarly journals Enhancing spatial perception through sound: mapping human movements into MIDI

2021 ◽  
Author(s):  
Bernardo Breve ◽  
Stefano Cirillo ◽  
Mariano Cuofano ◽  
Domenico Desiato
Keyword(s):  
Real Time ◽  
User Study ◽  
Spatial Perception ◽  
Human Movements ◽  
Different Types ◽  
Real Time Tracking ◽  
People’S Perceptions ◽  
Novel Algorithm

AbstractGestural expressiveness plays a fundamental role in the interaction with people, environments, animals, things, and so on. Thus, several emerging application domains would exploit the interpretation of movements to support their critical designing processes. To this end, new forms to express the people’s perceptions could help their interpretation, like in the case of music. In this paper, we investigate the user’s perception associated with the interpretation of sounds by highlighting how sounds can be exploited for helping users in adapting to a specific environment. We present a novel algorithm for mapping human movements into MIDI music. The algorithm has been implemented in a system that integrates a module for real-time tracking of movements through a sample based synthesizer using different types of filters to modulate frequencies. The system has been evaluated through a user study, in which several users have participated in a room experience, yielding significant results about their perceptions with respect to the environment they were immersed.

scholarly journals Digital Twin: Origin to Future

2021 ◽  
Vol 4 (2) ◽  
pp. 36
Author(s):  
Maulshree Singh ◽  
Evert Fuenmayor ◽  
Eoin Hinchy ◽  
Yuansong Qiao ◽  
Niall Murray ◽  
...  
Keyword(s):  
Real Time ◽  
Remote Access ◽  
Physical Entity ◽  
Industrial Systems ◽  
Digital Twin ◽  
Planning Optimization ◽  
Different Types ◽  
Pros And Cons ◽  
Number Of Publications ◽  
Digital Shadow

Digital Twin (DT) refers to the virtual copy or model of any physical entity (physical twin) both of which are interconnected via exchange of data in real time. Conceptually, a DT mimics the state of its physical twin in real time and vice versa. Application of DT includes real-time monitoring, designing/planning, optimization, maintenance, remote access, etc. Its implementation is expected to grow exponentially in the coming decades. The advent of Industry 4.0 has brought complex industrial systems that are more autonomous, smart, and highly interconnected. These systems generate considerable amounts of data useful for several applications such as improving performance, predictive maintenance, training, etc. A sudden influx in the number of publications related to ‘Digital Twin’ has led to confusion between different terminologies related to the digitalization of industries. Another problem that has arisen due to the growing popularity of DT is a lack of consensus on the description of DT as well as so many different types of DT, which adds to the confusion. This paper intends to consolidate the different types of DT and different definitions of DT throughout the literature for easy identification of DT from the rest of the complimentary terms such as ‘product avatar’, ‘digital thread’, ‘digital model’, and ‘digital shadow’. The paper looks at the concept of DT since its inception to its predicted future to realize the value it can bring to certain sectors. Understanding the characteristics and types of DT while weighing its pros and cons is essential for any researcher, business, or sector before investing in the technology.

Advanced Driver Assists and Safety Management System

2021 ◽  
Vol 6 (2) ◽  
Author(s):  
Dipti Chavan ◽  
Aniket Kamble ◽  
Aditya Khadsare ◽  
Vaibhav Chougule ◽  
Vaibhav Chougule
Keyword(s):  
Real Time ◽  
Automobile Industry ◽  
Safety Management ◽  
Public Utilities ◽  
Sensor Platform ◽  
Key Points ◽  
Different Types ◽  
Important Field ◽  
And Control ◽  
Web Platform

Electronics and communication is the most important field. In this paper, we can describe how much safety is in the Automobile industry. In this paper, we are using uno-Arduino. The different types of sensors facilities are also provided using key points. The different sensors are provided to check visitor count. In this system, we can monitor and control all the safety precautions their one IoT web platform. This helps in the proper utilization of drivers and helps in avoiding accidents. This paper can be implemented in any two-wheelers, heavily loaded trucks, small SUVs, compact cars. In our paper, the electronics machine/components will be automatically working with using of Arduino program. The proposed wireless sensor platform is an attempt to develop more safety devices that can be used in multiple areas such as homes, schools, and public utilities to reduce accidents. This Advanced Driver Assists system will provide real-time accident detections and monitoring usage information that helps in real-time by using GSM, GPS, and sensors.

scholarly journals Innovative Web Service Grammar for Streaming Computing in Real-Time Technology

2019 ◽  
Vol 9 (2) ◽  
pp. 1589-1595
Keyword(s):  
Real Time ◽  
Research Work ◽  
Parallel Flow ◽  
Streaming Data ◽  
Advanced Technologies ◽  
Query Result ◽  
Different Types ◽  
Pros And Cons ◽  
Event Flow ◽  
Streaming Computing

The purpose of this work is to develop a UJSON web technology with C# application to analyze the student data in real-ime. Execute continuous requests on JSON streaming data based on advanced technologies for parallel streaming computing, suitable for solving analytic problems and calculation of metrics in real-time. The developed management information system in this research work designed to filtering event flow, building an event flow as a query result, grouping and aggregation of events, and creating window semantics. For testing the proposed work, several queries were selected that implement aggregation with different types of semantic windows (Steps, Slides). Testing was done locally and on education moodle clusters. It was used 4 types of configurations 2, 4, 8, and 16 computing nodes. Based on the obtained results, scalability is noticeable with an increase in the number of nodes. The updated functions of the proposed UJSON could improve the construction of parallel flow systems and data processing. The developed approach based on modern and advanced parallel flow technologies for output calculations considering the pros and cons of various approaches found in the current era.

scholarly journals Utilizing drone technology in the civil engineering

2019 ◽  
Vol 14 (1) ◽  
pp. 27-37
Author(s):  
Matúš Tkáč ◽  
Peter Mésároš
Keyword(s):  
Real Time ◽  
Unmanned Aerial Vehicle ◽  
Civil Engineering ◽  
Aerial Images ◽  
General Overview ◽  
Aerial Photogrammetry ◽  
Different Types ◽  
Aerial Vehicle

Abstract An unmanned aerial vehicle (UAVs), also known as drone technology, is used for different types of application in the civil engineering. Drones as a tools that increase communication between construction participants, improves site safety, uses topographic measurements of large areas, with using principles of aerial photogrammetry is possible to create buildings aerial surveying, bridges, roads, highways, saves project time and costs, etc. The use of UAVs in the civil engineering can brings many benefits; creating real-time aerial images from the building objects, overviews reveal assets and challenges, as well as the broad lay of the land, operators can share the imaging with personnel on site, in headquarters and with sub-contractors, planners can meet virtually to discuss project timing, equipment needs and challenges presented by the terrain. The aim of this contribution is to create a general overview of the use of UAVs in the civil engineering. The contribution also contains types of UAVs used for construction purposes, their advantages and also disadvantages.

Recognition and calculation of objects in images using YOLOv3 architecture

2021 ◽  
Vol 26 (jai2021.26(2)) ◽  
pp. 42-53
Author(s):  
Hrabovskyi V ◽  
◽  
Kmet O ◽  
Keyword(s):  
Real Time ◽  
High Speed ◽  
High Reliability ◽  
Fruit Trees ◽  
Learning Technology ◽  
Visual Objects ◽  
Software Product ◽  
Different Types ◽  
Original Classification ◽  
Trained Network

Program that searches for five types of fruits in the images of fruit trees, classifies them and counts their quantity is presented. Its creation took into account the requirement to be able to work both in the background and in real time and to identify the desired objects at a sufficiently high speed. The program should also be able to learn from available computers (including laptops) and within a reasonable time. In carrying out this task, the possibilities of several existing approaches to the recognition and identification of visual objects based on the use of convolutional neural networks were analyzed. Among the considered network archi-tectures were R-CNN, Fast R-CNN, Faster R-CNN, SSD, YOLO and some modifications based on them. Based on the analysis of the peculiarities of their work, the YOLO architecture was used to perform the task, which allows the analy-sis of visual objects in real time with high speed and reliability. The software product was implemented by modifying the YOLOv3 architecture implemented in TensorFlow 2.1. Object recognition in this architecture is performed using a trained Darknet-53 network, the parameters of which are freely available. The modification of the network was to replace its original classification layer. The training of the network modified in this way was carried out on the basis of Transfer learning technology using the Agrilfruit Dataset. There was also a study of the peculiarities of the learning process of the network under the use of different types of gradient descent (stochastic and with the value of the batch 4 and 8), as a result of which the optimal version of the trained network weights was selected for further use. Tests of the modified and trained network have shown that the system based on it with high reliability distin-guishes objects of the corresponding classes of different sizes in the image (even with their significant masking) and counts their number. The ability of the program to distinguish and count the number of individual fruits in the analyzed image can be used to visually assess the yield of fruit trees

Efficient and Robust Approach for Heartbeat Detection of ECG Signal

2019 ◽  
Vol 29 (08) ◽  
pp. 2050133
Author(s):  
Anas Fouad Ahmed ◽  
Mohammed Abdulmunem Ahmed ◽  
Hussain Mustafa Bierk
Keyword(s):  
Real Time ◽  
Low Cost ◽  
Suggested Method ◽  
The Other ◽  
Ecg Signal ◽  
Excellent Performance ◽  
Robust Approach ◽  
Different Types ◽  
Three Stages ◽  
Electrocardiogram Ecg

This paper introduces an efficient and robust method for heartbeat detection based on the calculated angles between the successive samples of electrocardiogram (ECG) signal. The proposed approach involves three stages: filtering, computing the angles of the signal and thresholding. The suggested method is applied to two different types of ECG databases (QTDB and MIT-BIH). The results were compared with the other algorithms suggested in previous works. The proposed approach outperformed the other algorithms, in spite of its simplicity and their fast calculations. These features make it applicable in real-time ECG diagnostics systems. The suggested method was implemented in real-time using a low cost ECG acquisition system and it shows excellent performance.

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