scholarly journals The Primary Outbreaks of Burkitt Lymphoma in the Oral Cavity. A Report of Two Cases, Review of the Literature and Dental Implications

Diagnostics ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 2358
Author(s):  
Tomasz Kulczyk ◽  
Agata Daktera-Micker ◽  
Barbara Biedziak ◽  
Agnieszka Wziątek ◽  
Katarzyna Bednarek-Rajewska

Two cases of Sporadic Burkitt’s lymphoma in children aged 11 and 8 years with primary symptoms in the oral cavity are reported. The first symptoms of the disease appeared in the oral cavity and were initially misdiagnosed as an inflammatory condition in one case and incidental findings not associated with the primary reason for visiting the dentist’s office in the second case. Biopsies of the lesions revealed the actual cause of the observed changes and contributed to the prompt initiation of polychemotherapy treatment. A review of current literature presents the known symptoms of Burkitt’s Lymphoma in the oral cavity and the available diagnostic methods. The role of the primary care physicians—the pedodontist and paediatrician—in the diagnostic and therapeutic process is discussed.

1999 ◽  
Vol 73 (12) ◽  
pp. 9827-9831 ◽  
Author(s):  
Jun Komano ◽  
Seiji Maruo ◽  
Koichi Kurozumi ◽  
Takanori Oda ◽  
Kenzo Takada

ABSTRACT Our previous reports indicated that Epstein-Barr virus (EBV) contributes to the malignant phenotype and resistance to apoptosis in Burkitt’s lymphoma (BL) cell line Akata (N. Shimizu, A. Tanabe-Tochikura, Y. Kuroiwa, and K. Takada, J. Virol. 68:6069–6073, 1994; J. Komano, M. Sugiura, and K. Takada, J. Virol. 72:9150–9156, 1998). Here we report that the EBV-encoded small RNAs (EBERs) are responsible for these phenotypes. Transfection of the EBER genes into EBV-negative Akata clones restored the capacity for growth in soft agar, tumorigenicity in SCID mice, resistance to apoptotic inducers, and upregulated expression of bcl-2 oncoprotein that were originally retained in parental EBV-positive Akata cells and lost in EBV-negative subclones. This is the first report which provides evidence that virus-encoded RNAs (EBERs) have oncogenic functions in BL cells.


2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Stella Bernardi ◽  
Andrea Michelli ◽  
Deborah Bonazza ◽  
Veronica Calabrò ◽  
Fabrizio Zanconati ◽  
...  

2013 ◽  
Vol 6 (1) ◽  
pp. 46 ◽  
Author(s):  
Paola Bianchi ◽  
Francesco Torcia ◽  
Marta Vitali ◽  
Giuliana Cozza ◽  
Marco Matteoli ◽  
...  

Oncogene ◽  
2018 ◽  
Vol 37 (18) ◽  
pp. 2410-2421 ◽  
Author(s):  
Justine Debernardi ◽  
Emilie Hollville ◽  
Marc Lipinski ◽  
Joëlle Wiels ◽  
Aude Robert

2007 ◽  
Vol 86 (6) ◽  
pp. 356-360 ◽  
Author(s):  
Steven M. Feinberg ◽  
S.H. Ignatius Ou ◽  
Mai Gu ◽  
Terry Y. Shibuya

Burkitt's lymphoma is a highly aggressive, mature B cell non-Hodgkin's lymphoma that is rare outside Africa. We report a case of Burkitt's lymphoma presenting as a rapidly expanding tongue-base mass that caused airway obstruction in an 80-year-old Palestinian man living in California. According to our review of the literature, this is only the third reported case of Burkitt's lymphoma arising in the base of the tongue. We also discuss the incidence, epidemiology, genetics, prognosis, and treatment of this malignancy. Because Burkitt's lymphoma is one of the fastest-growing tumors in humans, rapid diagnosis and treatment are important. Treatment involves brief-duration, high-intensity chemotherapy and central nervous system prophylaxis. It is important for the otolaryngologist to recognize this disease and to understand the steps necessary to treat this aggressive tumor.


2009 ◽  
Vol 19 (6) ◽  
pp. 394-400 ◽  
Author(s):  
Bettina Gruhne ◽  
Siamak Akbari Kamranvar ◽  
Maria G. Masucci ◽  
Ramakrishna Sompallae

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