Effect of the Postural Challenge on the Dependence of the Cardiovascular Control Complexity on Age

Abstract:A computer model of cardiovascular control has been developed based on the response characteristics of cardiovascular control components derived from experiments in animals and humans. Results from the model were compared to those obtained experimentally in humans, and the similarities and differences were used to identify both the strengths and inadequacies of the concepts used to form the model. Findings were confirmatory of some concepts but contrary to some which are firmly held in the literature, indicating that understanding the complexity of cardiovascular control probably requires a combination of experiments and computer models which integrate multiple systems and allow for determination of sufficiency and necessity.

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Short term spaceflights influence autonomic cardiovascular control

57th International Astronautical Congress ◽

10.2514/6.iac-06-a1.7.04 ◽

2006 ◽

Author(s):

Dr. Frank Beckers ◽

Mr. Bart Verheyden ◽

Mr. Kurt Couckuyt ◽

Mr. Jiexin Liu ◽

Prof. André Aubert

Keyword(s):

Cardiovascular Control ◽

Short Term ◽

Autonomic Cardiovascular Control

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Endocannabinoids

10.1093/oso/9780190846848.003.0004 ◽

2018 ◽

Author(s):

Leslie Iversen

Keyword(s):

Arachidonic Acid ◽

Energy Metabolism ◽

Pain Sensitivity ◽

Large Family ◽

Cardiovascular Control ◽

Lipid Signaling ◽

Physiological Functions ◽

Functional Roles ◽

Metabolism Regulation ◽

Mediators Of Inflammation

The endocannabinoids are part of a large family of lipid signaling molecules derived from arachidonic acid, including the prostaglandins and leukotrienes, which are important mediators of inflammation. Far less is known about the newer members of the endocannabinoid group, and it remains unclear whether they all play important functional roles. This chapter reviews the multiple members of this family and their biosynthesis and inactivation. Physiological functions, including retrograde synaptic signaling, control of energy metabolism, regulation of pain sensitivity, and cardiovascular control, are discussed. In addition, the chapter reports the synthesis of novel agonists, antagonists, and compounds inhibiting endocannabinoid inactivation as novel medicines.

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Research progress on the mechanism of orexin in pain regulation in different brain regions

Open Life Sciences ◽

10.1515/biol-2021-0001 ◽

2021 ◽

Vol 16 (1) ◽

pp. 46-52

Author(s):

Xianhui Kang ◽

Hongli Tang ◽

Yao Liu ◽

Yan Yuan ◽

Mi Wang

Keyword(s):

Energy Metabolism ◽

Acute Pain ◽

Lateral Hypothalamus ◽

Brain Regions ◽

Cardiovascular Control ◽

Research Progress ◽

Orexin A ◽

Physiological Functions ◽

Pain Transmission ◽

Pain Regulation

Abstract Orexin is a neuropeptide that is primarily synthesized and secreted by the lateral hypothalamus (LH) and includes two substances derived from the same precursor (orexin A [OXA] and orexin B [OXB]). Studies have shown that orexin is not only involved in the regulation of eating, the sleep–wake cycle, and energy metabolism, but also closely associated with various physiological functions, such as cardiovascular control, reproduction, stress, reward, addiction, and the modulation of pain transmission. At present, studies that have been performed both domestically and abroad have confirmed that orexin and its receptors are closely associated with pain regulation. In this article, the research progress on acute pain regulation involving orexin is reviewed.

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