scholarly journals Silver nanoprisms enhances <em>in vitro</em> photodynamic activity of methylene blue against <em>Candida albicans</em>

2021 ◽  
Author(s):  
Beate Santos ◽  
Cláudio Rodrigues ◽  
Marques Silva ◽  
Adriana Fontes ◽  
Danielle Macêdo
2002 ◽  
Vol 75 (4) ◽  
pp. 392 ◽  
Author(s):  
Kirste J. Mellish ◽  
Russell D. Cox ◽  
David I. Vernon ◽  
John Griffiths ◽  
Stanley B. Brown

2019 ◽  
Vol 26 ◽  
pp. 193-198 ◽  
Author(s):  
Franak Daliri ◽  
Arash Azizi ◽  
Mehdi Goudarzi ◽  
Shirin Lawaf ◽  
Arash Rahimi

2007 ◽  
Vol 75 (4) ◽  
pp. 392-397 ◽  
Author(s):  
Kirste J. Mellish ◽  
Russell D. Cox ◽  
David I. Vernon ◽  
John Griffiths ◽  
Stanley B. Brown

2015 ◽  
Vol 12 (1) ◽  
pp. 52-57 ◽  
Author(s):  
Reza Fekrazad ◽  
Vadood Ghasemi Barghi ◽  
Arash Poorsattar Bejeh Mir ◽  
Masoumeh Shams-Ghahfarokhi

2011 ◽  
Vol 55 (12) ◽  
pp. 5710-5717 ◽  
Author(s):  
Tianhong Dai ◽  
Vida J. Bil de Arce ◽  
George P. Tegos ◽  
Michael R. Hamblin

ABSTRACTThe objective of this study was to investigate photodynamic therapy (PDT), using blue dye and red light, for prophylaxis and treatment of cutaneousCandida albicansinfections in mice. A mouse model of skin abrasion infected withC. albicanswas developed by inoculating wounds measuring 1.2 cm by 1.2 cm with 106or 107CFU. The use of a luciferase-expressing strain ofC. albicansallowed real-time monitoring of the extent of infection in mice noninvasively through bioluminescence imaging. The phenothiazinium salts toluidine blue O (TBO), methylene blue (MB), and new methylene blue (NMB) were compared as photosensitizers (PS) for the photodynamic inactivation ofC. albicansin vitro. PDTin vivowas initiated either at 30 min or at 24 h after fungal inoculation to investigate the efficacies of PDT for both prophylaxis and treatment of infections. Light at 635 ± 15 nm or 660 ± 15 nm was delivered with a light dose of 78 J/cm2(for PDT at 30 min postinfection) or 120 J/cm2(for PDT at 24 h postinfection) in multiple exposures with bioluminescence imaging taking place after each exposure of light.In vitrostudies showed that NMB was superior to TBO and MB as the PS in the photodynamic inactivation ofC. albicans. The efficacy of PDT was related to the ratio of PS concentration to fungal cell density. PDTin vivoinitiated either at 30 min or at 24 h postinfection significantly reducedC. albicansburden in the infected mouse skin abrasion wounds. These data suggest that PDT is a viable approach for prophylaxis and treatment of cutaneousC. albicansinfections.


2017 ◽  
Vol 9 (2) ◽  
pp. 71
Author(s):  
Nurhasanah Nurhasanah ◽  
Fauzia Andrini ◽  
Yulis Hamidy

Shallot (Allium ascalonicum L.) has been known as traditional medicine. Shallot which has same genus with garlic(Allium sativum L.) contains allicin that is also found in garlic and has been suspected has fungicidal activity toCandida albicans. It is supported by several researches. Therefore, shallot is suspected has antifungal activity too.The aim of this research was to know antifungal activity of shallot’s water extortion againsts Candida albicans invitro. This was a laboratory experimental research which used completely randomized design, with diffusion method.Shallot’s water extortion was devided into three concentrations, there were 50%, 100% and 200%. Ketoconazole 2%was positive control and aquadest was negative control. The result of this research based on analysis of varians(Anova), there was significant difference between several treatments and was confirmed with Duncan New MultipleRange Test (DNMRT) p<0,05, there was significant difference between 100% shallot’s water extortion with othertreatments, but there was no significant difference between 50% shallot’s water extortion with 200% shallot’s. Theconclusion was shallot’s water extortion had antifungal activity againsts Candida albicans with the best concentration100%, but it was lower than ketoconazole 2%.


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