scholarly journals A Comprehensive Analysis of Deep Neural-Based Cerebral Microbleeds Detection System

Electronics ◽  
2021 ◽  
Vol 10 (18) ◽  
pp. 2208
Author(s):  
Maria Anna Ferlin ◽  
Michał Grochowski ◽  
Arkadiusz Kwasigroch ◽  
Agnieszka Mikołajczyk ◽  
Edyta Szurowska ◽  
...  
Keyword(s):  
Machine Learning ◽  
Detection System ◽  
Three Dimensional ◽  
Magnetic Resonance Images ◽  
Cerebral Microbleeds ◽  
Training Data ◽  
Learning Approach ◽  
Dimensional Problem ◽  
Reliable System ◽  
Machine Learning Approach

Machine learning-based systems are gaining interest in the field of medicine, mostly in medical imaging and diagnosis. In this paper, we address the problem of automatic cerebral microbleeds (CMB) detection in magnetic resonance images. It is challenging due to difficulty in distinguishing a true CMB from its mimics, however, if successfully solved, it would streamline the radiologists work. To deal with this complex three-dimensional problem, we propose a machine learning approach based on a 2D Faster RCNN network. We aimed to achieve a reliable system, i.e., with balanced sensitivity and precision. Therefore, we have researched and analysed, among others, impact of the way the training data are provided to the system, their pre-processing, the choice of model and its structure, and also the ways of regularisation. Furthermore, we also carefully analysed the network predictions and proposed an algorithm for its post-processing. The proposed approach enabled for obtaining high precision (89.74%), sensitivity (92.62%), and F1 score (90.84%). The paper presents the main challenges connected with automatic cerebral microbleeds detection, its deep analysis and developed system. The conducted research may significantly contribute to automatic medical diagnosis.

A Survey on Intrusion Detection System for Software Defined Networks (SDN)

2020 ◽  
Vol 16 (1) ◽  
pp. 28-47 ◽  
Author(s):  
Yogita Hande ◽  
Akkalashmi Muddana
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Intrusion Detection ◽  
Network Architecture ◽  
Detection System ◽  
Learning Approach ◽  
Distinctive Features ◽  
Detection Systems ◽  
Security Challenges ◽  
Machine Learning Approach

Presently, the advances of the internet towards a wide-spread growth and the static nature of traditional networks has limited capacity to cope with organizational business needs. The new network architecture software defined networking (SDN) appeared to address these challenges and provides distinctive features. However, these programmable and centralized approaches of SDN face new security challenges which demand innovative security mechanisms like intrusion detection systems (IDS's). The IDS of SDN are designed currently with a machine learning approach; however, a deep learning approach is also being explored to achieve better efficiency and accuracy. In this article, an overview of the SDN with its security concern and IDS as a security solution is explained. A survey of existing security solutions designed to secure the SDN, and a comparative study of various IDS approaches based on a deep learning model and machine learning methods are discussed in the article. Finally, we describe future directions for SDN security.

scholarly journals A machine learning approach to define antimalarial drug action from heterogeneous cell-based screens

2020 ◽  
Vol 6 (39) ◽  
pp. eaba9338 ◽  
Author(s):  
George W. Ashdown ◽  
Michelle Dimon ◽  
Minjie Fan ◽  
Fernando Sánchez-Román Terán ◽  
Kathrin Witmer ◽  
...  
Keyword(s):  
Machine Learning ◽  
Mechanism Of Action ◽  
Training Data ◽  
Supervised Machine Learning ◽  
Cross Resistance ◽  
Learning Approach ◽  
Imaging Data ◽  
Drug Induced ◽  
Effective Prevention ◽  
Machine Learning Approach

Drug resistance threatens the effective prevention and treatment of an ever-increasing range of human infections. This highlights an urgent need for new and improved drugs with novel mechanisms of action to avoid cross-resistance. Current cell-based drug screens are, however, restricted to binary live/dead readouts with no provision for mechanism of action prediction. Machine learning methods are increasingly being used to improve information extraction from imaging data. These methods, however, work poorly with heterogeneous cellular phenotypes and generally require time-consuming human-led training. We have developed a semi-supervised machine learning approach, combining human- and machine-labeled training data from mixed human malaria parasite cultures. Designed for high-throughput and high-resolution screening, our semi-supervised approach is robust to natural parasite morphological heterogeneity and correctly orders parasite developmental stages. Our approach also reproducibly detects and clusters drug-induced morphological outliers by mechanism of action, demonstrating the potential power of machine learning for accelerating cell-based drug discovery.

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