scholarly journals A Portal to Visualize Transcriptome Profiles in Mouse Models of Neurological Disorders

Genes ◽  
2019 ◽  
Vol 10 (10) ◽  
pp. 759 ◽  
Author(s):  
Al-Ouran ◽  
Wan ◽  
Mangleburg ◽  
Lee ◽  
Allison ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mouse Model ◽  
Mouse Models ◽  
Neurological Disorders ◽  
Neurological Diseases ◽  
Model Organisms ◽  
Model Studies ◽  
Brain Gene Expression ◽  
Step Model ◽  
Examine Gene Expression

Target nomination for drug development has been a major challenge in the path to finding a cure for several neurological disorders. Comprehensive transcriptome profiles have revealed brain gene expression changes associated with many neurological disorders, and the functional validation of these changes is a critical next step. Model organisms are a proven approach for the elucidation of disease mechanisms, including screening of gene candidates as therapeutic targets. Frequently, multiple models exist for a given disease, creating a challenge to select the optimal model for validation and functional follow-up. To help in nominating the best mouse models for studying neurological diseases, we developed a web portal to visualize mouse transcriptomic data related to neurological disorders: http://mmad.nrihub.org. Users can examine gene expression changes across mouse model studies to help select the optimal mouse model for further investigation. The portal provides access to mouse studies related to Alzheimer’s diseases (AD), Parkinson’s disease (PD), Huntington’s disease (HD), Amyotrophic Lateral Sclerosis (ALS), Spinocerebellar ataxia (SCA), and models related to aging.

Multiplex Three-Dimensional Brain Gene Expression Mapping in a Mouse Model of Parkinson's Disease

2002 ◽  
Vol 12 (6) ◽  
pp. 868-884 ◽  
Author(s):  
V. M. Brown ◽  
A. Ossadtchi ◽  
A. H. Khan ◽  
S. Yee ◽  
G. Lacan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Three Dimensional ◽  
Brain Gene Expression ◽  
Gene Expression Mapping

Altered brain gene expression profiles associated with the pathogenesis of phenylketonuria in a mouse model

2009 ◽  
Vol 401 (1-2) ◽  
pp. 90-99 ◽  
Author(s):  
Joo-Won Park ◽  
Eun-Sook Park ◽  
Eun Nam Choi ◽  
Hae-Young Park ◽  
Sung-Chul Jung
Keyword(s):  
Gene Expression ◽  
Mouse Model ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Brain Gene Expression

scholarly journals O4-10-03: FUNCTIONAL DISSECTION OF ALZHEIMER'S DISEASE BRAIN GENE EXPRESSION SIGNATURES IN HUMANS AND MOUSE MODELS

2019 ◽  
Vol 15 ◽  
pp. P1260-P1260
Author(s):  
Carl Grant Mangleburg ◽  
Ying-Wooi Wan ◽  
Rami Al-Ouran ◽  
Tom V. Lee ◽  
Katherine S. Allison ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Brain Gene Expression ◽  
Gene Expression Signatures

scholarly journals Feminized Behavior and Brain Gene Expression in a Novel Mouse Model of Klinefelter Syndrome

2014 ◽  
Vol 43 (6) ◽  
pp. 1043-1057 ◽  
Author(s):  
Tuck C. Ngun ◽  
Negar M. Ghahramani ◽  
Michelle M. Creek ◽  
Shayna M. Williams-Burris ◽  
Hayk Barseghyan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mouse Model ◽  
Klinefelter Syndrome ◽  
Brain Gene Expression

scholarly journals Transcript profiles of stria vascularis in models of Waardenburg syndrome

2019 ◽  
Author(s):  
Linjun Chen ◽  
Yi Wang ◽  
Lei Chen ◽  
Fangyuan wang ◽  
Fei Ji ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mouse Model ◽  
Mouse Models ◽  
Stria Vascularis ◽  
Specific Gene ◽  
Waardenburg Syndrome ◽  
Significant Difference ◽  
Tyrosine Metabolism ◽  
Transcript Profiles ◽  
And Function

Abstract Background: Waardenburg syndrome is a common syndromic hereditary deafness disease caused by stria vascularis dysfunction. However, the genetic pathway affecting stria vascularis development is still not clear. In this paper, the transcript profile of stria vascularis of Waardenburg syndrome was studied using Mitf-M mutant pigs and mice models. GO analysis was performed to identify the differential gene expression caused by Mitf-M mutation. Results: There were over than one hundred genes mainly found in tyrosine metabolism, melanin formation and ion transportations showed significant changes in both models. In addition, there were some spiced specific gene changes in the stria vascularis in the mouse and porcine models. The expression of tight junction-associated genes, including Cadm1, Cldn11, Pcdh1, Pcdh19 and Cdh24 genes , were significantly higher in porcine models compared to mouse models. Vascular-related and ion channel-related genes in the stria vascularis were also shown significantly difference between the two species. The expression of Col2a1, Col3a1, Col11a1 and Col11a2 genes were higher and the expression of Col8a2, Cd34 and Ncam genes were lower in the porcine model compared to mouse model. In both models, Trpm1, Kcnj13, and Slc45a2 genes were both affected by the Mitf-M mutation. In the pig models, the expression of Kcnn1, Clcn2 and Trpm4 genes were higher than the mouse model; whereas the expression of Trpm7, Kcnq1 and Kcnj8 genes were higher in the mouse models than the pig models. However, there was no significant difference in the morphology of the stria vascularis between these two models. Conclusions: Our data suggests that there is a significant difference on the gene expression and function between these two models.

scholarly journals Strain-specific differences in brain gene expression in a hydrocephalic mouse model with motile cilia dysfunction

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Casey W. McKenzie ◽  
Claudia C. Preston ◽  
Rozzy Finn ◽  
Kathleen M. Eyster ◽  
Randolph S. Faustino ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mouse Model ◽  
Brain Gene Expression ◽  
Motile Cilia

scholarly journals Brain gene expression correlates with changes in behavior in the R6/1 mouse model of Huntington’s disease

2008 ◽  
Vol 7 (3) ◽  
pp. 288-299 ◽  
Author(s):  
A. Hodges ◽  
G. Hughes ◽  
S. Brooks ◽  
L. Elliston ◽  
P. Holmans ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mouse Model ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Brain Gene Expression
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