Brain gene expression in systemic hypothyroidism and mouse models of MCT8 deficiency: The Mct8-Oatp1c1-Dio2 triad.

Thyroid ◽  
2020 ◽  
Author(s):  
Beatriz Morte ◽  
Pilar Gil-Ibañez ◽  
Heike Heuer ◽  
Juan Bernal
Keyword(s):  
Gene Expression ◽  
Mouse Models ◽  
Brain Gene Expression ◽  
Mct8 Deficiency

scholarly journals O4-10-03: FUNCTIONAL DISSECTION OF ALZHEIMER'S DISEASE BRAIN GENE EXPRESSION SIGNATURES IN HUMANS AND MOUSE MODELS

2019 ◽  
Vol 15 ◽  
pp. P1260-P1260
Author(s):  
Carl Grant Mangleburg ◽  
Ying-Wooi Wan ◽  
Rami Al-Ouran ◽  
Tom V. Lee ◽  
Katherine S. Allison ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Brain Gene Expression ◽  
Gene Expression Signatures

scholarly journals A Portal to Visualize Transcriptome Profiles in Mouse Models of Neurological Disorders

Genes ◽  
2019 ◽  
Vol 10 (10) ◽  
pp. 759 ◽  
Author(s):  
Al-Ouran ◽  
Wan ◽  
Mangleburg ◽  
Lee ◽  
Allison ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mouse Model ◽  
Mouse Models ◽  
Neurological Disorders ◽  
Neurological Diseases ◽  
Model Organisms ◽  
Model Studies ◽  
Brain Gene Expression ◽  
Step Model ◽  
Examine Gene Expression

Target nomination for drug development has been a major challenge in the path to finding a cure for several neurological disorders. Comprehensive transcriptome profiles have revealed brain gene expression changes associated with many neurological disorders, and the functional validation of these changes is a critical next step. Model organisms are a proven approach for the elucidation of disease mechanisms, including screening of gene candidates as therapeutic targets. Frequently, multiple models exist for a given disease, creating a challenge to select the optimal model for validation and functional follow-up. To help in nominating the best mouse models for studying neurological diseases, we developed a web portal to visualize mouse transcriptomic data related to neurological disorders: http://mmad.nrihub.org. Users can examine gene expression changes across mouse model studies to help select the optimal mouse model for further investigation. The portal provides access to mouse studies related to Alzheimer’s diseases (AD), Parkinson’s disease (PD), Huntington’s disease (HD), Amyotrophic Lateral Sclerosis (ALS), Spinocerebellar ataxia (SCA), and models related to aging.

Decrease in the T-box1 gene expression in embryonic brain and adult hippocampus of down syndrome mouse models

2021 ◽  
Vol 535 ◽  
pp. 87-92
Author(s):  
Ryohei Shimizu ◽  
Keiichi Ishihara ◽  
Eri Kawashita ◽  
Haruhiko Sago ◽  
Kazuhiro Yamakawa ◽  
...  
Keyword(s):  
Gene Expression ◽  
Down Syndrome ◽  
Mouse Models ◽  
Embryonic Brain ◽  
Adult Hippocampus

Effect of combination of peripheral oxytocin and naltrexone at subthreshold doses on food intake, body weight and feeding-related brain gene expression in male rats

2021 ◽  
pp. 113464
Author(s):  
Mitchell A. Head ◽  
Allen S. Levine ◽  
David G. Christian ◽  
Anica Klockars ◽  
Pawel K. Olszewski
Keyword(s):  
Gene Expression ◽  
Body Weight ◽  
Food Intake ◽  
Male Rats ◽  
Brain Gene Expression

scholarly journals Inflammatory gene expression signature in mouse models of obstructive and neurogenic bladder dysfunction

2020 ◽  
Vol 19 ◽  
pp. e279
Author(s):  
M. Kueffer ◽  
M. Besic ◽  
H.G. Ali ◽  
N. Haghayegh Jahromi ◽  
M. Schneider ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mouse Models ◽  
Neurogenic Bladder ◽  
Bladder Dysfunction ◽  
Gene Expression Signature ◽  
Neurogenic Bladder Dysfunction ◽  
Inflammatory Gene Expression ◽  
Inflammatory Gene ◽  
Expression Signature

scholarly journals Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications

2012 ◽  
Vol 7 (1) ◽  
pp. 13 ◽  
Author(s):  
Mariet Allen ◽  
Fanggeng Zou ◽  
High Chai ◽  
Curtis S Younkin ◽  
Richard Miles ◽  
...  
Keyword(s):  
Gene Expression ◽  
Parkinson Disease ◽  
Association Study ◽  
Disease Risk ◽  
Age At Diagnosis ◽  
Glutathione S Transferase ◽  
Brain Gene Expression

Nutrition and division of labor: Effects on foraging and brain gene expression in the paper wasp Polistes metricus

2011 ◽  
Vol 20 (24) ◽  
pp. 5337-5347 ◽  
Author(s):  
T. H. F. DAUGHERTY ◽  
A. L. TOTH ◽  
G. E. ROBINSON
Keyword(s):  
Gene Expression ◽  
Division Of Labor ◽  
Paper Wasp ◽  
Brain Gene Expression ◽  
Polistes Metricus
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