scholarly journals TLR4 Polymorphism, Nasopharyngeal Bacterial Colonization, and the Development of Childhood Asthma: A Prospective Birth-Cohort Study in Finnish Children

Genes ◽  
2020 ◽  
Vol 11 (7) ◽  
pp. 768
Author(s):  
Johanna T. Teräsjärvi ◽  
Laura Toivonen ◽  
Juho Vuononvirta ◽  
Jussi Mertsola ◽  
Ville Peltola ◽  
...  
Keyword(s):  
Cohort Study ◽  
Childhood Asthma ◽  
Moraxella Catarrhalis ◽  
Bacterial Colonization ◽  
Birth Cohort Study ◽  
Quantitative Culture ◽  
Increased Risk ◽  
Prospective Birth Cohort ◽  
Prospective Birth Cohort Study

We aimed to explore the role of TLR4 (rs4986790) polymorphism in the nasopharyngeal (NP) bacterial colonization and its consequent impact on the development of childhood asthma. A semi-quantitative culture of NP swabs was performed on 473 children at 2 months of age and on 213 children at 13 months of age. TLR4 polymorphism was analyzed for 396 children. Children were followed from birth to the age of 7.5 years and the final outcome was physician-diagnosed asthma. The associations between TLR4 genotype, bacterial colonization, and asthma were analyzed. Children with TLR4 AG or GG genotype were more often colonized with Moraxella catarrhalis at 2 months of age (p = 0.009) and Haemophilus influenzae at 13 months of age (p = 0.018). Children who were colonized with H. influenzae at 13 months of age had a significantly higher risk of later development of asthma (p = 0.004). M. catarrhalis or H. Influenzae colonization at 2 months of age or TLR4 genotype Asp299Gly were not associated with the development of childhood asthma. TLR4 Asp299Gly polymorphism was associated with an increased risk of colonization of M. catarrhalis and H. influenzae in children. The colonization with H. influenzae at 13 months of age was associated with a higher risk of later development of childhood asthma.

scholarly journals The role of early life variables on the risk of fractures from birth to early adolescence: a prospective birth cohort study

2009 ◽  
Vol 20 (11) ◽  
pp. 1873-1879 ◽  
Author(s):  
P. C. Hallal ◽  
F. V. Siqueira ◽  
A. M. B. Menezes ◽  
C. L. P. Araújo ◽  
S. A. Norris ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Cohort ◽  
Early Adolescence ◽  
Early Life ◽  
Birth Cohort Study ◽  
Prospective Birth Cohort ◽  
Prospective Birth Cohort Study

scholarly journals Mode of delivery at birth and the metabolic syndrome in midlife: the role of the birth environment in a prospective birth cohort study

BMJ Open ◽  
2014 ◽  
Vol 4 (5) ◽  
pp. e005031 ◽  
Author(s):  
Béatrice Bouhanick ◽  
Virginie Ehlinger ◽  
Cyrille Delpierre ◽  
Bernard Chamontin ◽  
Thierry Lang ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cohort Study ◽  
Birth Cohort ◽  
Mode Of Delivery ◽  
Birth Cohort Study ◽  
The Metabolic Syndrome ◽  
Birth Environment ◽  
Prospective Birth Cohort ◽  
Prospective Birth Cohort Study

Modes of Infant Feeding and the Risk of Childhood Asthma: A Prospective Birth Cohort Study

2017 ◽  
Vol 190 ◽  
pp. 192-199.e2 ◽  
Author(s):  
Annika Klopp ◽  
Lorena Vehling ◽  
Allan B. Becker ◽  
Padmaja Subbarao ◽  
Piushkumar J. Mandhane ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Cohort ◽  
Infant Feeding ◽  
Childhood Asthma ◽  
Birth Cohort Study ◽  
Prospective Birth Cohort ◽  
Prospective Birth Cohort Study

scholarly journals Daycare attendance and respiratory tract infections: a prospective birth cohort study

BMJ Open ◽  
2017 ◽  
Vol 7 (9) ◽  
pp. e014635 ◽  
Author(s):  
Linnea Schuez-Havupalo ◽  
Laura Toivonen ◽  
Sinikka Karppinen ◽  
Anne Kaljonen ◽  
Ville Peltola
Keyword(s):  
Cohort Study ◽  
Respiratory Tract ◽  
Birth Cohort ◽  
Day Care ◽  
Repeated Measures ◽  
Respiratory Tract Infections ◽  
Birth Cohort Study ◽  
Tract Infections ◽  
Prospective Birth Cohort ◽  
Prospective Birth Cohort Study

ObjectiveWe explored the burden of respiratory tract infections (RTIs) in young children with regard to day-care initiation.DesignLongitudinal prospective birth cohort study.Setting and methodsWe recruited 1827 children for follow-up until the age of 24 months collecting diary data on RTIs and daycare. Children with continuous daycare type and complete data were divided into groups of centre-based daycare (n=299), family day care (FDC) (n=245) and home care (n=350). Using repeated measures variance analyses, we analysed days per month with symptoms of respiratory tract infection, antibiotic treatments and parental absence from work for a period of 6 months prior to and 9 months after the start of daycare.ResultsWe documented a significant effect of time and type of daycare, as well as a significant interaction between them for all outcome measures. There was a rise in mean days with symptoms from 3.79 (95% CI 3.04 to 4.53) during the month preceding centre-based daycare to 10.57 (95% CI 9.35 to 11.79) at 2 months after the start of centre-based daycare, with a subsequent decrease within the following 9 months. Similar patterns with a rise and decline were observed in the use of antibiotics and parental absences. The start of FDC had weaker effects. Our findings were not changed when taking into account confounding factors.ConclusionsOur study shows the rapid increase in respiratory infections after start of daycare and a relatively fast decline in the course of time with continued daycare. It is important to support families around the beginning of daycare.

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