scholarly journals Antibiotic Treatment Response in Chronic Lyme Disease: Why Do Some Patients Improve While Others Do Not?

Healthcare ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 383 ◽  
Author(s):  
Lorraine Johnson ◽  
Mira Shapiro ◽  
Raphael B. Stricker ◽  
Joshua Vendrow ◽  
Jamie Haddock ◽  
...  
Keyword(s):  
Lyme Disease ◽  
Treatment Response ◽  
Machine Learning Techniques ◽  
Global Rating ◽  
Duration Of Treatment ◽  
Considerable Uncertainty ◽  
Chronic Lyme Disease ◽  
Learning Techniques ◽  
Response Variation ◽  
High Treatment

There is considerable uncertainty regarding treatment of Lyme disease patients who do not respond fully to initial short-term antibiotic therapy. Choosing the best treatment approach and duration remains challenging because treatment response among these patients varies: some patients improve with treatment while others do not. A previous study examined treatment response variation in a sample of over 3500 patients enrolled in the MyLymeData patient registry developed by LymeDisease.org (San Ramon, CA, USA). That study used a validated Global Rating of Change (GROC) scale to identify three treatment response subgroups among Lyme disease patients who remained ill: nonresponders, low responders, and high responders. The present study first characterizes the health status, symptom severity, and percentage of treatment response across these three patient subgroups together with a fourth subgroup, patients who identify as well. We then employed machine learning techniques across these subgroups to determine features most closely associated with improved patient outcomes, and we used traditional statistical techniques to examine how these features relate to treatment response of the four groups. High treatment response was most closely associated with (1) the use of antibiotics or a combination of antibiotics and alternative treatments, (2) longer duration of treatment, and (3) oversight by a clinician whose practice focused on the treatment of tick-borne diseases.

scholarly journals Feature Selection from Lyme Disease Patient Survey Using Machine Learning

Algorithms ◽  
2020 ◽  
Vol 13 (12) ◽  
pp. 334
Author(s):  
Joshua Vendrow ◽  
Jamie Haddock ◽  
Deanna Needell ◽  
Lorraine Johnson
Keyword(s):  
Machine Learning ◽  
Lyme Disease ◽  
Large Scale ◽  
Disease Patient ◽  
Patient Survey ◽  
Machine Learning Techniques ◽  
Medical Community ◽  
Support Vector ◽  
Global Rating ◽  
K Nearest Neighbors

Lyme disease is a rapidly growing illness that remains poorly understood within the medical community. Critical questions about when and why patients respond to treatment or stay ill, what kinds of treatments are effective, and even how to properly diagnose the disease remain largely unanswered. We investigate these questions by applying machine learning techniques to a large scale Lyme disease patient registry, MyLymeData, developed by the nonprofit LymeDisease.org. We apply various machine learning methods in order to measure the effect of individual features in predicting participants’ answers to the Global Rating of Change (GROC) survey questions that assess the self-reported degree to which their condition improved, worsened, or remained unchanged following antibiotic treatment. We use basic linear regression, support vector machines, neural networks, entropy-based decision tree models, and k-nearest neighbors approaches. We first analyze the general performance of the model and then identify the most important features for predicting participant answers to GROC. After we identify the “key” features, we separate them from the dataset and demonstrate the effectiveness of these features at identifying GROC. In doing so, we highlight possible directions for future study both mathematically and clinically.

scholarly journals Treatment Response Prediction in Hepatitis C Patients using Machine Learning Techniques

2021 ◽  
Vol 1 (2) ◽  
pp. 79-89
Author(s):  
Ashfaq Ali Kashif ◽  
Birra Bakhtawar ◽  
Asma Akhtar ◽  
Samia Akhtar ◽  
Nauman Aziz ◽  
...  
Keyword(s):  
Machine Learning ◽  
Hepatitis C ◽  
Treatment Response ◽  
Nearest Neighbor ◽  
Response Prediction ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
K Nearest Neighbor ◽  
Learning Techniques ◽  
Treatment Response Prediction

The proper prognosis of treatment response is crucial in any medical therapy to reduce the effects of the disease and of the medication as well. The mortality rate due to hepatitis c virus (HCV) is high in Pakistan as well as all over the world. During the treatment of any disease, prediction of treatment response against any particular medicine is difficult. This paper focuses on predicting the treatment response of a drug: “L-ornithine L-Aspartate (LOLA)” in hepatitis c patients. We have used various machine learning techniques for the prediction of treatment response, including: “K Nearest Neighbor, kStar, Naive Bayes, Random Forest, Radial Basis Function, PART, Decision Tree, OneR, Support Vector Machine and Multi-Layer Perceptron”. Performance measures used to analyze the performance of used machine learning techniques include, “Accuracy, Recall, Precision, and F-Measure”.

Using machine learning techniques to reduce data annotation time

2006 ◽  
Author(s):  
Christopher Schreiner ◽  
Kari Torkkola ◽  
Mike Gardner ◽  
Keshu Zhang
Keyword(s):  
Machine Learning ◽  
Machine Learning Techniques ◽  
Data Annotation ◽  
Learning Techniques

Using Machine Learning Algorithms on Prediction of Stock Price

2020 ◽  
Vol 12 (2) ◽  
pp. 84-99
Author(s):  
Li-Pang Chen
Keyword(s):  
Machine Learning ◽  
Stock Price ◽  
Short Term Memory ◽  
Machine Learning Algorithms ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Short Term ◽  
Learning Techniques ◽  
Historical Database ◽  
Long Short Term Memory

In this paper, we investigate analysis and prediction of the time-dependent data. We focus our attention on four different stocks are selected from Yahoo Finance historical database. To build up models and predict the future stock price, we consider three different machine learning techniques including Long Short-Term Memory (LSTM), Convolutional Neural Networks (CNN) and Support Vector Regression (SVR). By treating close price, open price, daily low, daily high, adjusted close price, and volume of trades as predictors in machine learning methods, it can be shown that the prediction accuracy is improved.

389-P: Ability for Detecting or Predicting Hypoglycemia with the Aid of Machine Learning Techniques: A Meta-analysis

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 389-P
Author(s):  
SATORU KODAMA ◽  
MAYUKO H. YAMADA ◽  
YUTA YAGUCHI ◽  
MASARU KITAZAWA ◽  
MASANORI KANEKO ◽  
...  
Keyword(s):  
Machine Learning ◽  
Meta Analysis ◽  
Machine Learning Techniques ◽  
Learning Techniques

A Comparative Study of Different Machine Learning Algorithms for Disease Prediction

2017 ◽  
Vol 7 (7) ◽  
pp. 172
Author(s):  
Anantvir Singh Romana
Keyword(s):  
Machine Learning ◽  
Subsequent Treatment ◽  
Machine Learning Algorithms ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Disease Prediction ◽  
Classification Problems ◽  
Learning Techniques ◽  
Neural Network Classifiers ◽  
Diagnostic Detection

Accurate diagnostic detection of the disease in a patient is critical and may alter the subsequent treatment and increase the chances of survival rate. Machine learning techniques have been instrumental in disease detection and are currently being used in various classification problems due to their accurate prediction performance. Various techniques may provide different desired accuracies and it is therefore imperative to use the most suitable method which provides the best desired results. This research seeks to provide comparative analysis of Support Vector Machine, Naïve bayes, J48 Decision Tree and neural network classifiers breast cancer and diabetes datsets.

A Brief Survey on Text Classification Using Various Machine Learning Techniques

2018 ◽  
Vol 8 (1) ◽  
pp. 14
Author(s):  
Padmavathi .S ◽  
M. Chidambaram
Keyword(s):  
Machine Learning ◽  
Text Classification ◽  
Fixed Number ◽  
Machine Learning Techniques ◽  
Online Information ◽  
Rule Based ◽  
Learning Techniques ◽  
Machine Learning Approach ◽  
Rule Based Approach

Text classification has grown into more significant in managing and organizing the text data due to tremendous growth of online information. It does classification of documents in to fixed number of predefined categories. Rule based approach and Machine learning approach are the two ways of text classification. In rule based approach, classification of documents is done based on manually defined rules. In Machine learning based approach, classification rules or classifier are defined automatically using example documents. It has higher recall and quick process. This paper shows an investigation on text classification utilizing different machine learning techniques.

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