scholarly journals Polymorphisms in Four Genes (KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963) and Their Correlation with Type 2 Diabetes Mellitus in Han Chinese in Henan Province, China

Author(s):  
Kaiping Gao ◽  
Jinjin Wang ◽  
Linlin Li ◽  
Yujia Zhai ◽  
Yongcheng Ren ◽  
...  
Gene ◽  
2014 ◽  
Vol 534 (2) ◽  
pp. 352-355 ◽  
Author(s):  
Linlin Li ◽  
Kaiping Gao ◽  
Jingzhi Zhao ◽  
Tianping Feng ◽  
Lei Yin ◽  
...  

2018 ◽  
Vol 23 (1) ◽  
pp. 349-354 ◽  
Author(s):  
Yanhong Zhang ◽  
Yuanyuan Lin ◽  
Jianwu Zhang ◽  
Li Li ◽  
Xinxin Liu ◽  
...  

2016 ◽  
Vol 7 (6) ◽  
pp. 853-859 ◽  
Author(s):  
Meidong Yao ◽  
Yanhui Wu ◽  
Qingxiao Fang ◽  
Lulu Sun ◽  
Tingting Li ◽  
...  

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Wan-Chun Liu ◽  
Chi-Chih Hung ◽  
Szu-Chia Chen ◽  
Ming-Yen Lin ◽  
Ling-I Chen ◽  
...  

Aims. TheSLC2A9gene encodes the glucose transporter 9, with the abilities of transporting both glucose and uric acid and is involved in the pancreatic glucose-stimulated insulin secretion. The single nucleotide polymorphisms (SNPs) ofSLC2A9accounted for 5% variance of serum uric acid (UA). UA was identified as a risk factor for type 2 diabetes mellitus (DM). We investigated whether theSLC2A9gene variations are associated with type 2 DM in Han Chinese.Methods. Three common SNPs of theSLC2A9, rs1014290, rs2280205, and rs3733591, were genotyped in 1003 Han Chinese randomly selected from Kaohsiung, Taiwan.Results. The variant SNP rs1014290 is associated with decreased 0.12-fold risk of type 2 DM (P=.002). Per-copy increase in the minor C-allele results in 0.13 mmol/L (P=.037) and 10.03 μmol/L (P=.016) decrease in serum glucose and UA, respectively.Conclusions. The SNP rs1014290 within theSLC2A9gene is associated with type 2 DM in Han Chinese.


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