scholarly journals Sex and Gender Interactions on the Use and Impact of Recreational Cannabis

2020 ◽  
Vol 17 (2) ◽  
pp. 509 ◽  
Author(s):  
Lorraine Greaves ◽  
Natalie Hemsing
Keyword(s):  
Cannabis Use ◽  
Public Health Issue ◽  
Sex And Gender ◽  
Related Factors ◽  
Precise Integration ◽  
Routes Of Administration ◽  
Wide Range ◽  
Scoping Reviews ◽  
And Gender ◽  
The Impact

Cannabis is the second most frequently used substance in the world and regulated or legalized for recreational use in Canada and fourteen US states and territories. As with all substances, a wide range of sex and gender related factors have an influence on how substances are consumed, their physical, mental and social impacts, and how men and women respond to treatment, health promotion, and policies. Given the widespread use of cannabis, and in the context of its increasing regulation, it is important to better understand the sex and gender related factors associated with recreational cannabis use in order to make more precise clinical, programming, and policy decisions. However, sex and gender related factors include a wide variety of processes, features and influences that are rarely fully considered in research. This article explores myriad features of both sex and gender as concepts, illustrates their impact on cannabis use, and focuses on the interactions of sex and gender that affect three main areas of public interest: the development of cannabis use dependence, the impact on various routes of administration (ROA), and the impact on impaired driving. We draw on two separate scoping reviews to examine available evidence in regard to these issues. These three examples are described and illustrate the need for more comprehensive and precise integration of sex and gender in substance use research, as well as serious consideration of the results of doing so, when addressing a major public health issue such as recreational cannabis use.

scholarly journals Sex-Related Factors in Cardiovascular Complications Associated to COVID-19

Biomolecules ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 21
Author(s):  
Francesca Megiorni ◽  
Paola Pontecorvi ◽  
Giulia Gerini ◽  
Eleni Anastasiadou ◽  
Cinzia Marchese ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Cardiovascular Complications ◽  
Sex And Gender ◽  
Biological Factors ◽  
Related Factors ◽  
Gender Influence ◽  
Behavioral Cues ◽  
And Gender ◽  
The Impact ◽  
Symptoms And Signs

Coronavirus disease 2019 (COVID-19), the pandemic infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), presents with an extremely heterogeneous spectrum of symptoms and signs. The clinical manifestations seem to be correlated with disease severity. COVID-19 susceptibility and mortality show a significant sex imbalance, with men being more prone to infection and showing a higher rate of hospitalization and mortality compared to women. Such variability can be ascribed to both sex-related biological factors and gender-related behavioral cues. This review will discuss the potential mechanisms accounting for sex/gender influence in vulnerability to COVID-19. Cardiovascular diseases play a central role in determining COVID-19 outcome, whether they are pre-existent or arose upon infection. We will pay particular attention to the impact of sex and gender on cardiovascular manifestations related to COVID-19. Finally, we will discuss the sex-dependent variability in some biomarkers for the evaluation of COVID-19 infection and prognosis. The aim of this work is to highlight the significance of gendered medicine in setting up personalized programs for COVID-19 prevention, clinical evaluation and treatment.

Abstract 15580: The Impact of Sex and Gender-related Factors on Length-of-stay Following NSTEMI: A Multicountry Analysis

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Uri Bender ◽  
Colleen M Norris ◽  
Valeria Raparelli ◽  
Tadiri Christina ◽  
Louise Pilote
Keyword(s):  
Length Of Stay ◽  
Cardiac Risk ◽  
Hospital Length ◽  
Hospital Length Of Stay ◽  
Bivariate Analysis ◽  
P Value ◽  
Sex And Gender ◽  
Related Factors ◽  
And Gender ◽  
The Impact

Introduction: Gender refers to psycho-socio-cultural characteristics typically ascribed to men, women and gender-diverse individuals and has been shown to be associated with adverse clinical outcomes in AMI independent of sex. Substantial heterogeneity in hospital length of stay exists among patients admitted with NSTEMI. Whether sex and gender-based differences contribute to length-of-stay (LOS) among patients with NSTEMI remains unknown. Methods: To examine the relationship between sex, gender-related factors and LOS in adults hospitalized for NSTEMI, data from the GENESIS-PRAXY (n=1,210, Canada, U.S. and Switzerland), EVA (n=430, Italy) and VIRGO (n=3,572, U.S., Spain and Australia) studies of adults hospitalized for AMI were combined and analyzed. A best-fit linear regression model was selected through incremental analysis by stepwise addition of gender-related variables thought to be different in either impact or distribution between men and women. Results: Among the overall cohort (n=5,212), 2,218 participants with a diagnosis of NSTEMI were included in the final cohort (66% women, mean age 48.5 years, 67.8% U.S.). Half of the patients had a LOS of longer than 4 days (n=1,124) and were more likely to be white and have a clustering of cardiac risk factors in comparison to those with shorter LOS. No association between sex and LOS was observed in the bivariate analysis (p=0.87). In the multivariable model adjusted for sex, age, country of hospitalization, level of education, marital status, employment status, income, and social support, age (0.062 days/year, p=0.0002), being employed (-0.63 days in workers, p=0.01) and the treatment country relative to Canada (Italy=4.1 days; Spain=1.7 days; and the U.S.=-1.0 days, all p-value<0.001) were significant predictors of LOS. Conclusions: Employed individuals are more likely to experience a shorter LOS following NSTEMI. Variation in LOS exists across different countries and is likely due to institutional policy, resource allocation, and differences in cultural and psychosocial influences.

scholarly journals Women’s health in times of COVID-19 pandemic. Do sex and gender matter?

2021 ◽  
Vol 131 (1) ◽  
pp. 71-75
Author(s):  
Joanna Zembala-John
Keyword(s):  
Economic Consequences ◽  
Sex And Gender ◽  
Key Factors ◽  
Related Factors ◽  
Men And Women ◽  
And Gender ◽  
The Impact ◽  
Harmful Effects

Abstract The COVID-19 epidemic has negatively affected all spheres of life, leading to the deterioration of health and quality of life. Although it has affected both men and women, it has had an extraordinary impact on the latter, exposing and exacerbating the existing health inequalities among those groups. There is increasing evidence that both sex and gender-related factors make women more prone to the harmful effects of SARS-CoV-2. Therefore, it is expected that the crisis caused by coronavirus will have long-term severe medical, social, and economic consequences in this population. This paper aimed to investigate the key factors contributing to the different outcomes of COVID-19 in men and women and present multi-dimensional effects of coronavirus pandemic from the perspective of women. Sex and gender differences must not be ignored in analyzing the impact of COVID-19. Sex/gender-oriented approach should be implemented in all public health actions: from collecting sex-disaggregated data to designing tailored repair post-COVID policies.

scholarly journals Gender Differences in Diabetic Kidney Disease: Focus on Hormonal, Genetic and Clinical Factors

2021 ◽  
Vol 22 (11) ◽  
pp. 5808
Author(s):  
Annalisa Giandalia ◽  
Alfio Edoardo Giuffrida ◽  
Guido Gembillo ◽  
Domenico Cucinotta ◽  
Giovanni Squadrito ◽  
...  
Keyword(s):  
Gender Differences ◽  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Clinical Manifestations ◽  
Current Evidence ◽  
Sex And Gender ◽  
Clinical Factors ◽  
Diabetic Kidney ◽  
And Gender ◽  
The Impact

Diabetic kidney disease (DKD) is one of the most serious complications of both type 1 (T1DM) and type 2 diabetes mellitus (T2DM). Current guidelines recommend a personalized approach in order to reduce the burden of DM and its complications. Recognizing sex and gender- differences in medicine is considered one of the first steps toward personalized medicine, but the gender issue in DM has been scarcely explored so far. Gender differences have been reported in the incidence and the prevalence of DKD, in its phenotypes and clinical manifestations, as well as in several risk factors, with a different impact in the two genders. Hormonal factors, especially estrogen loss, play a significant role in explaining these differences. Additionally, the impact of sex chromosomes as well as the influence of gene–sex interactions with several susceptibility genes for DKD have been investigated. In spite of the increasing evidence that sex and gender should be included in the evaluation of DKD, several open issues remain uncovered, including the potentially different effects of newly recommended drugs, such as SGLT2i and GLP1Ras. This narrative review explored current evidence on sex/gender differences in DKD, taking into account hormonal, genetic and clinical factors.

scholarly journals The Impact of Sex and Gender on Adaptation to Space: Executive Summary

2014 ◽  
Vol 23 (11) ◽  
pp. 941-947 ◽  
Author(s):  
Saralyn Mark ◽  
Graham B.I. Scott ◽  
Dorit B. Donoviel ◽  
Lauren B. Leveton ◽  
Erin Mahoney ◽  
...  
Keyword(s):  
Sex And Gender ◽  
Executive Summary ◽  
And Gender ◽  
The Impact

scholarly journals 2801. Post-Natal Zika Virus Infection and Impact on Neurodevelopment Among a Cohort of Children in Rural Guatemala

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S990-S991
Author(s):  
Daniel Olson ◽  
Molly Lamb ◽  
Amy Connery ◽  
Kathryn Colborn ◽  
Muktha S Natrajan ◽  
...  
Keyword(s):  
Zika Virus ◽  
Receptive Language ◽  
Fine Motor ◽  
Serum Samples ◽  
Zikv Infection ◽  
Related Factors ◽  
Material Support ◽  
And Gender ◽  
The Impact ◽  
Research Grant

Abstract Background The impact of early post-natal Zika virus (ZIKV) infection on neurodevelopment (ND) is unknown. A prospective study of post-natal ZIKV infection in rural Guatemala (ZIKV study) enrolled a cohort of children ages 1–5 years, including children previously enrolled in a dengue virus (DENV) study during the 2015–2016 ZIKV epidemic. We evaluated ND outcomes by age and ZIKV infection status. Methods Subjects enrolled in the ZIKV study June 2017–April 2018 underwent ND testing using the Mullen Scales of Early Learning (MSEL) at baseline and 12 months later. ZIKV/DENV-1/2 FRNT50 was performed on enrollment and on banked serum samples from the 2015 to 2016 subset. ZIKV serostatus and MSEL scores were correlated using multiple linear mixed models, adjusted for age and gender when appropriate, to evaluate their association. Geolocation was used to explore clustering of ZIKV serostatus and MSEL score. Results We enrolled 183 children (43% female, mean age 3.2 years). Of these, 38 (21%) were classified as ZIKV-positive (+), 111 (61%) ZIKV-negative (-), 31 (17%) ZIKV-possible, and 3 (2%) ZIKV-indeterminate. ZIKV(+) cases and higher composite MSEL scores clustered in more densely populated areas (Figure 1). ZIKV(+) serostatus was associated with higher MSEL composite (increase in log score 0.09, P = 0.003) and subdomain scores: fine motor (0.13, P = 0.011), visual reception (0.15, P = 0.002), receptive language (0.09, P = 0.041), gross motor (0.14, P = 0.09), and expressive language (0.09, P = 0.058) (Figure 2). Of the 78 children (43%) with 2015–2016 samples, 46 (59%) remained ZIKV(−), 16 (21%) seroconverted from ZIKV(−) or possible/indeterminate to ZIKV(+), and 16 (21%) were indeterminate when enrolled in the ZIKV study. ZIKV seroconversion was associated with higher composite (0.13, P = 0.02) MSEL scores compared with ZIKV(−). Conclusion In this exploratory analysis, post-natal ZIKV infection was not associated with adverse ND outcomes in children age 1–5 years. Overall, ZIKV(+) status was associated with higher average ND scores than ZIKV(−), and scores decreased with age for most children, independent of ZIKV status. The correlation of ZIKV(+) status and higher MSEL scores may be confounded by geographic-related factors or other confounders. NIAID Contract HHSN272201300015I Task Order HHSN27200013 (Co-PIs: FMM & EJA). Disclosures Flor M. Munoz, M.D, Biocryst: Grant/Research Support; CDC: Research Grant; Moderna: Other Financial or Material Support, Safety Monitoring Board Member/Chair; NIH: Research Grant; Novavax: Research Grant; UP to Date: Author and Editor - Royalties, Other Financial or Material Support.

Socialist/Marxist Feminism

2020 ◽  
Author(s):  
Wendy Lynne Lee
Keyword(s):  
Civil Rights ◽  
Political Ecology ◽  
Sex And Gender ◽  
Communist Manifesto ◽  
Original Intent ◽  
Wide Range ◽  
Women's Lives ◽  
And Gender ◽  
Material Conditions ◽  
The 1960S

The long arc of Marxist scholarship certainly reaches many domains—economics, sociology, political ecology. However, few scholarly projects have likely benefited more, or offered more, to sustaining the relevance of Marx and Marxism than the feminist analysis, interpretation, and application of the Marxist critique of capitalism. From the earliest translations of Marxist thought into revolutionary action, socialist feminists have sought to introduce sex and gender as salient categories of capitalist oppression, arguing that being a woman bound to patriarchal institutions such as marriage is comparable to a working-class laborer bound to the wage. Friedrich Engels also plays a key role in the socialist feminist appropriation of Marxist ideas. By showing the extent to which marriage is about the maintenance and expansion of property, Engels opens the door to a wide range of analysis concerning the material conditions of women’s lives and labors. Marxist ideas become the focus of renewed interest over the course of the American civil rights and feminist movements of the 1960s. It is thus unsurprising that a wealth of new feminist and antiracist theories begin to develop during this period, as well as analyses of structural inequality, including oppression with respect to the LGBTQ community. It is perhaps the most recent work among socialist feminists, in league with other activists and theorists, however, that is both truest to Marx’s original intent and that demonstrates the relevance of his ideas to the future fortunes of human societies, namely, the application of Marxist critique to environmental deterioration—especially anthropogenic climate change. Hence, the following is organized historically but also topically. It begins with the work of early socialist feminists, looking to include women within Marxist categories of class analysis but quickly moves to arguments that sex and gender—and then race/ethnicity and sexual identity—constitute their own salient categories of oppression. This explosion of theory and activism deserves to be treated topically so that the variety and breadth of socialist feminist ideas as well as the divisions and debates among its representatives becomes clear. The critique of capitalism has, of course, always been an essentially global enterprise. It is thus not surprising that the extension of socialist feminist analyses to the Global North and Global South would produce a wealth of insight and activism. For many of the same reasons, the same is true of the rise of socialist ecofeminism. The last section comes full circle. Devoted to arguments whose focus is the justification and fomenting of revolution, The Communist Manifesto finds its place next to contemporary socialist ecofeminist calls for workers from all regions of the planet to unite to overthrow once and for all the capitalist economic system responsible for jeopardizing the planet’s capacity to support life.

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