Sex-Related Factors in Cardiovascular Complications Associated to COVID-19

Coronavirus disease 2019 (COVID-19), the pandemic infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), presents with an extremely heterogeneous spectrum of symptoms and signs. The clinical manifestations seem to be correlated with disease severity. COVID-19 susceptibility and mortality show a significant sex imbalance, with men being more prone to infection and showing a higher rate of hospitalization and mortality compared to women. Such variability can be ascribed to both sex-related biological factors and gender-related behavioral cues. This review will discuss the potential mechanisms accounting for sex/gender influence in vulnerability to COVID-19. Cardiovascular diseases play a central role in determining COVID-19 outcome, whether they are pre-existent or arose upon infection. We will pay particular attention to the impact of sex and gender on cardiovascular manifestations related to COVID-19. Finally, we will discuss the sex-dependent variability in some biomarkers for the evaluation of COVID-19 infection and prognosis. The aim of this work is to highlight the significance of gendered medicine in setting up personalized programs for COVID-19 prevention, clinical evaluation and treatment.

Dichotomous Activity and Function of Neurons with Low- and High-Frequency Discharge in the External Globus Pallidus of Non-Human Primates

To date, there is a consensus that there are at least two neuronal populations in the non-human primate (NHP) external globus pallidus (GPe): the low- and high-frequency discharge (LFD and HFD) neurons. Nevertheless, almost all NHP physiological studies have neglected the functional importance of LFD neurons. This study examined the discharge features of these two GPe neuronal subpopulations recorded in four NHPs engaged in a classical conditioning task with cues predicting reward, neutral and aversive outcomes. The results show that LFD neurons tended to burst, encoded the salience of behavioral cues, and exhibited correlated spiking activity. By contrast, the HFD neurons tended to pause, encoded cue valence, and exhibited uncorrelated spiking activity. Overall, these findings point to the dichotomic organization of the NHP GPe which is likely to be critical to the implementation of normal basal ganglia functions and computations.

Outgroup threat and the emergence of cohesive groups: A cross-cultural examination

Evolutionary models and empirical evidence suggest that outgroup threat is one of the strongest factors inducing group cohesion; however, little is known about the process of forming such cohesive groups. We investigated how outgroup threat galvanizes individuals to affiliate with others to form engaged units that are willing to act on behalf of their in-group. A total of 864 participants from six countries were randomly assigned to an outgroup threat, environmental threat, or no-threat condition. We measured the process of group formation through physical proximity and movement mirroring along with activity toward threat resolution, and found that outgroup threat induced activity and heightened mirroring in males. We also observed higher mirroring and proximity in participants who perceived the outgroup threat as a real danger, albeit the latter results were imprecisely estimated. Together, these findings help understand how sharing subtle behavioral cues influences collaborative aggregation of people under threat.

Evaluation of the Attitudes and Confidence of Veterinary Undergraduates toward Working with Cats in the Veterinary Hospital Environment

An understanding of feline behavior is required to successfully handle cats in the hospital environment and avoid triggering escalation to fear-aggression due to heightened anxiety. Some veterinary students appear to misinterpret feline behavioral cues, resulting in frustration and poor success when performing basic handling. This article investigates the following in regard to veterinary students and feline handling: (a) attitudes toward working with feline patients in the hospital environment; (b) experience of working with feline patients; (c) satisfaction in acquisition of feline handling and examination skills; and, (d) confidence in feline handling skills; and to explore influencing factors. An electronic questionnaire was circulated to 4th and final year veterinary students (May 2012) and final year students (June 2013) for anonymous voluntary completion. 173/293 students completed the questionnaire. Of final year respondents, 87/115 (75.7%) indicated that they enjoy interacting with cats in veterinary hospitals; 95/115 (82.6%) indicated that they were satisfied with their cat handling skills; 105/115 (91.3%) felt confident handling quiet and wriggly cats; significantly fewer 63/115 (54.8%) felt confident handling unpredictable cats ( p < 0.05). Factors significantly affecting confidence in handling unpredictable cats included: frequency of examination practice during extra-mural studies ( p < 0.05), enjoyment of interacting with cats in veterinary hospitals ( p < 0.05), self-perceived understanding of feline behavior ( p < 0.05), self-perceived ability to interpret cats’ behavioral expressions ( p < 0.05), satisfaction with cat handling skills ( p < 0.05) and perception of feline versus canine handling ability ( p < 0.05).

The Indexical Voice: Communication of Personal States and Traits in Humans and Other Primates

Many studies of primate vocalization have been undertaken to improve our understanding of the evolution of language. Perhaps, for this reason, investigators have focused on calls that were thought to carry symbolic information about the environment. Here I suggest that even if these calls were in fact symbolic, there were independent reasons to question this approach in the first place. I begin by asking what kind of communication system would satisfy a species’ biological needs. For example, where animals benefit from living in large groups, I ask how members would need to communicate to keep their groups from fragmenting. In this context, I discuss the role of social grooming and “close calls,” including lip-smacking and grunting. Parallels exist in human societies, where information is exchanged about all kinds of things, often less about the nominal topic than the communicants themselves. This sort of indexical (or personal) information is vital to group living, which presupposes the ability to tolerate, relate to, and interact constructively with other individuals. Making indexical communication the focus of comparative research encourages consideration of somatic and behavioral cues that facilitate relationships and social benefits, including cooperation and collaboration. There is ample room here for a different and potentially more fruitful approach to communication in humans and other primates, one that focuses on personal appraisals, based on cues originating with individuals, rather than signals excited by environmental events.

Effects of dead conspecifics, hunger states, and seasons on the foraging behavior of the purple urchin Heliocidaris crassispina

Trophic cascades are a powerful result of predator-prey relationships in an ecosystem. In aquatic environments, the signals associated with predators and predation are used by prey as a cue to avoid encountering predators when foraging for food. These behavioral cues can be powerful enough to control prey populations and indirectly protect primary producers. Here, we evaluated the effects of cues associated with predation on the purple urchin Heliocidaris crassispina and examined effects of hunger state and season, using time-lapse photography. A series of laboratory and in situ manipulative experiments were conducted to determine patterns of foraging behavior and behavioral modifications. We showed that starved urchins were less sensitive to predation cues compared to normally fed urchins. Field experiments indicated that 70% of fed urchins fled when exposed to a predation cue (presence of a dead urchin) whereas starved urchins remained regardless of the cue, supporting results from the laboratory using dead urchin and algal cues. Sea urchin activity and feeding rates were lower in winter-spring than in summer-autumn. Results suggest that hunger state has a large influence over the behavioral response of sea urchins, while also being affected by season due to metabolic control. In general, starvation appears to override predator avoidance behaviors, which exposes prey species to higher risks of predation.

Masculinized Drosophila females adapt their fighting strategies to their opponent

Many animal species show aggression to gain mating partners and to protect territories and other resources from competitors. Both male and female fruit flies of the species Drosophila melanogaster exhibit aggression in same-sex pairings, but the strategies used are sexually dimorphic. We have begun to explore the biological basis for the differing aggression strategies, and the cues promoting one form of aggression over the other. Here, we describe a line of genetically masculinized females that switch between male and female aggression patterns based on the sexual identity of their opponents. When these masculinized females are paired with more aggressive opponents, they increase the amount of male-like aggression they use, but do not alter the level of female aggression. This suggests that male aggression may be more highly responsive to behavioral cues than female aggression. Although the masculinized females of this line show opponent-dependent changes in aggression and courtship behavior, locomotor activity and sleep are unaffected. Thus, the driver line used may specifically masculinize neurons involved in social behavior. A discussion of possible different roles of male and female aggression in fruit flies is included here. These results can serve as precursors to future experiments aimed at elucidating the circuitry and triggering cues underlying sexually dimorphic aggressive behavior.

Improving Eyewitness-Identification Evidence Through Double-Blind Lineup Administration

Lineups and photo arrays are often presented to witnesses by police officers who know which lineup member is the suspect (single-blind lineup administration) rather than by officers who do not know (double-blind administration). Administrators who are not blind to which lineup member is the suspect are more likely than blind administrators to emit behavioral cues that steer witnesses toward choosing the suspect and away from choosing fillers (i.e., a lineup member who is not the suspect). Moreover, nonblind administrators may provide confirmatory feedback to witnesses who identify the suspect, increasing their confidence in the accuracy of their identification and weakening the correlation between witness confidence and accuracy. Nonblind administrators are also more likely to interpret witnesses’ tentative statements about a suspect than about a filler as a positive identification. Because of these findings that single-blind administration biases identifications against suspects, even when they are innocent, evidence-based recommendations for best practices in the collection of eyewitness-identification evidence call for the use of double-blind lineup-administration procedures.