Sedentary Patterns Are Associated with Bone Mineral Density and Physical Function in Older Adults: Cross-Sectional and Prospective Data

Aging causes some unfavorable morphological and functional changes, such as the decline in bone mineral density (BMD) and physical function. Moderate-to-vigorous physical activity (MVPA) and sedentary time seem to be related with these alterations, but the impact of distinct patterns remains unclear. The aim of this study was to cross-sectionally and prospectively assess the association between objectively measured MVPA and sedentary patterns (bouts and breaks) with BMD and physical function in older adults. The study considered 151 Brazilians (aged ≥ 60 years), out of which 68 participants completed 2-year follow-up measurements. MVPA and sedentary patterns were measured by means of accelerometry, BMD—(total proximal femur and lumbar spine (L1-L4)) by means of dual-energy X-ray absorptiometry (DXA), and physical function—by means of physical tests. In older women, sedentary bouts >60 min were inversely associated with handgrip strength (β = −2.03, 95% CI: from −3.43 to −0.63). The prospective analyses showed that changes in sedentary bouts (20 to 30 min and >60 min) were inversely associated with changes in the lumbar spine’s BMD (β = −0.01, 95% CI: from −0.01 to −0.00 and β = −0.03, 95% CI: from −0.06 to −0.01) and the lumbar spine’s T-score (β = −0.06, 95% CI: from −0.10 to −0.01 and β = −0.27, 95% CI: from −0.49 to −0.04), respectively. In older women, sedentary patterns are cross-sectionally associated with handgrip strength and prospectively associated with BMD independent of MVPA.

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LIVING ALONE IS ASSOCIATED WITH POORER PHYSICAL FUNCTION AND BONE MINERAL DENSITY IN ICELANDIC OLD ADULTS

Innovation in Aging ◽

10.1093/geroni/igz038.1793 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

pp. S482-S482

Author(s):

Alfons Ramel

Keyword(s):

Bone Mineral Density ◽

Older Adults ◽

Physical Function ◽

Bone Mineral ◽

Community Dwelling ◽

Living Alone ◽

Z Score ◽

Mineral Density ◽

Old Adults ◽

Wide Range

Abstract Background: Loneliness and living alone have been significant public health concerns among older adults given their association with a wide range of adverse health outcomes. Aim: The aim of this study was to examine whether living alone is associated with physical function and bone health in community-dwelling older adults. Methods: This was a secondary analysis of existing cross-sectional data of old adults (N=182, 73.7±5.7yrs, 58.2% female) from the Reykjavik capital area in Iceland. Information on socioeconomics, health, dietary intake and physical function was collected. 25-hydroxy-vitamin D (25OHD) and bone mineral density (BM were grouped retrospectively into “living alone” and into “in cohabitation”. Results: Of our subjects, 76.4% were in cohabitation and and 23.6% lived alone. Participants who lived alone were older (74.5±5.6 vs. 72.1±5.0,P=0.008) and more often female (74.4 vs. 53.2%,P=0.014), but there were no differences in education, smoking, number of medications, physical activity (PA) or body mass index (BMI). According to age and gender corrected analyses, participants in cohabitation had higher grip strength (6.2±2.4lb,P=0.011), higher 25OHD (13.1±6.3nmol/L,P=0.037) and higher BMD (z-score lumbal: 1.195±0.417,P=0.005; z-score femur: 0.421±0.219,P=0.054; z-score total: 0.846±0.290,P=0.004). Statistical correction for PA, BMI, education and fish oil intake did not change the results. Conclusion: In comparison to old adults who live in cohabitation, Icelandic old adults who live alone have poorer physical function, lower 25OHD and lower BMD, which increases their risk for wrist or hip fracture. These differences between groups were not explained by physical, dietary or social confounding variables.

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Do Older Adults With Reduced Bone Mineral Density Benefit From Strength Training? A Critically Appraised Topic

Journal of Sport Rehabilitation ◽

10.1123/jsr.2019-0170 ◽

2020 ◽

Vol 29 (6) ◽

pp. 833-840

Author(s):

Maja Zamoscinska ◽

Irene R. Faber ◽

Dirk Büsch

Keyword(s):

Bone Mineral Density ◽

Older Adults ◽

Lumbar Spine ◽

Strength Training ◽

Older Women ◽

Bone Mineral ◽

Pathological Condition ◽

Developed Countries ◽

Mineral Density ◽

Bottom Line

Clinical Scenario: Reduced bone mineral density (BMD) is a serious condition in older adults. The mild form, osteopenia, is often a precursor of osteoporosis. Osteoporosis is a pathological condition and a global health problem as it is one of the most common diseases in developed countries. Finding solutions for prevention and therapy should be prioritized. Therefore, the critically appraised topic focuses on strength training as a treatment to counteract a further decline in BMD in older adults. Clinical Question: Is strength training beneficial in increasing BMD in older people with osteopenia or osteoporosis? Summary of Key Findings: Four of the 5 reviewed studies with the highest evidence showed a significant increase in lumbar spine BMD after strength training interventions in comparison with control groups. The fifth study confirmed the maintenance of lumbar spine density due to conducted exercises. Moreover, 3 reviewed studies revealed increasing BMD at the femoral neck after strength training when compared with controls, which appeared significant in 2 of them. Clinical Bottom Line: The findings indicate that strength training has a significant positive influence on BMD in older women (ie, postmenopausal) with osteoporosis or osteopenia. However, it is not recommended to only rely on strength training as the increase of BMD may not appear fast enough to reach the minimal desired values. A combination of strength training and supplements/medication seems most adequate. Generalization of the findings to older men with reduced BMD should be done with caution due to the lack of studies. Strength of Recommendation: There is grade B of recommendation to support the validity of strength training for older women in postmenopausal phase with reduced BMD.

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Associations between bone turnover markers and bone mineral density in older adults

Journal of Orthopaedic Surgery ◽

10.1177/2309499020987653 ◽

2021 ◽

Vol 29 (1) ◽

pp. 230949902098765

Author(s):

Zhongxin Zhu ◽

Hongliang Zhou ◽

Yanfei Wang ◽

Xiaocong Yao

Keyword(s):

Bone Mineral Density ◽

Older Adults ◽

Linear Regression ◽

Bone Turnover ◽

Older Women ◽

Bone Mineral ◽

Bone Turnover Markers ◽

Negative Association ◽

Mineral Density ◽

Turnover Markers

Objective: To examine the associations between bone turnover markers (BTMs) and bone mineral density (BMD) in older adults aged 60–85 years. Methods: A total of 1124 men (mean age, 69.1 years) and 1203 women (mean age, 70.7 years) from the National Health and Nutrition Examination Survey 1999–2002 were included in this cross-sectional analysis. Independent variables were serum bone-specific alkaline phosphatase (sBAP) and urinary N-telopeptide (uNTx), which are biomarkers of bone formation and resorption, respectively. Outcome variable was lumbar BMD. The associations of sBAP and uNTx levels with lumbar BMD was examined using multivariable linear regression models. Results: sBAP was negatively associated with lumbar BMD in each multivariable linear regression model, and this negative association was stable in both men and women men (men: β = −0.0028, 95% CI: −0.0046 to −0.0010; women: β = −0.0039, 95% CI: −0.0054 to −0.0023). On the other hand, uNTx was negatively associated with lumbar BMD after adjustment of relevant covariables (β = −0.0328, 95% CI: −0.0523 to −0.0133). However, in the subgroup analysis stratified by gender, this negative association remained only in older women (β = −0.0491, 95% CI: −0.0751 to −0.0231). Conclusion: Our study suggested that elevated sBAP and uNTX levels correlated with decreased lumbar BMD, especially in older women. This finding indicated that maintaining BTMs at low levels may be beneficial to bone health for older adults.

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