scholarly journals Understanding the Relationship between Environmental Arsenic and Prostate Cancer Aggressiveness among African-American and European-American Men in North Carolina

2020 ◽  
Vol 17 (22) ◽  
pp. 8364
Author(s):  
Humberto Parada ◽  
Tianying Wu ◽  
Rebecca C. Fry ◽  
Laura Farnan ◽  
Gary J. Smith ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
North Carolina ◽  
African American ◽  
African American Men ◽  
European American ◽  
Total Arsenic ◽  
Cross Sectional ◽  
Low Level ◽  
Cancer Aggressiveness ◽  
Arsenical Species

High-level exposure to arsenic, a known carcinogen and endocrine disruptor, is associated with prostate cancer (PCa) mortality. Whether low-level exposure is associated with PCa aggressiveness remains unknown. We examined the association between urinary arsenic and PCa aggressiveness among men in North Carolina. This cross-sectional study included 463 African-American and 491 European-American men with newly diagnosed, histologically confirmed prostate adenocarcinoma. PCa aggressiveness was defined as low aggressive (Gleason score < 7, stage = cT1–cT2, and PSA < 10 ng/mL) versus intermediate/high aggressive (all other cases). Total arsenic and arsenical species (inorganic arsenic (iAsIII + iAsV), arsenobetaine, monomethyl arsenic, and dimethyl arsenic)) and specific gravity were measured in spot urine samples obtained an average of 23.7 weeks after diagnosis. Multivariable logistic regression was used to estimate the covariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for PCa aggressiveness in association with arsenic tertiles/quantiles overall and by race. The highest (vs. lowest) tertile of total arsenic was associated with PCa aggressiveness ORs of 1.77 (95% CI = 1.05–2.98) among European-American men, and 0.94 (95% CI = 0.57–1.56) among African-American men (PInteraction = 0.04). In contrast, total arsenic and arsenical species were not associated with PCa aggressiveness in unstratified models. Low-level arsenic exposure may be associated with PCa aggressiveness among European-Americans, but not among African-Americans.

MP28-19 EVALUATING THE PROGNOSTIC UTILITY OF THE CCP SCORE FOR PREDICTING PROSTATE CANCER AGGRESSIVENESS IN AFRICAN AMERICAN MEN

2017 ◽  
Vol 197 (4S) ◽  
Author(s):  
Stephen Bardot ◽  
Julia Reid ◽  
Maria Latsis ◽  
Margaret Variano ◽  
Shams Halat ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
African American Men ◽  
Cancer Aggressiveness ◽  
Prognostic Utility

scholarly journals Comparative analysis of 1152 African-American and European-American men with prostate cancer identifies distinct genomic and immunological differences

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Walter Rayford ◽  
Alp Tuna Beksac ◽  
Jordan Alger ◽  
Mohammed Alshalalfa ◽  
Mohsen Ahmed ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
African American Men ◽  
Molecular Subtype ◽  
European American ◽  
Beta Catenin ◽  
Expression Of Genes ◽  
Repair Genes ◽  
Clinical Genomic ◽  
Lower Expression

AbstractRacial disparities in prostate cancer have not been well characterized on a genomic level. Here we show the results of a multi-institutional retrospective analysis of 1,152 patients (596 African-American men (AAM) and 556 European-American men (EAM)) who underwent radical prostatectomy. Comparative analyses between the race groups were conducted at the clinical, genomic, pathway, molecular subtype, and prognostic levels. The EAM group had increased ERG (P < 0.001) and ETS (P = 0.02) expression, decreased SPINK1 expression (P < 0.001), and basal-like (P < 0.001) molecular subtypes. After adjusting for confounders, the AAM group was associated with higher expression of CRYBB2, GSTM3, and inflammation genes (IL33, IFNG, CCL4, CD3, ICOSLG), and lower expression of mismatch repair genes (MSH2, MSH6) (p < 0.001 for all). At the pathway level, the AAM group had higher expression of genes sets related to the immune response, apoptosis, hypoxia, and reactive oxygen species. EAM group was associated with higher levels of fatty acid metabolism, DNA repair, and WNT/beta-catenin signaling. Based on cell lines data, AAM were predicted to have higher potential response to DNA damage. In conclusion, biological characteristics of prostate tumor were substantially different in AAM when compared to EAM.

Patient Satisfaction Influenced by Interpersonal Treatment and Communication for African American Men

2012 ◽  
Vol 6 (5) ◽  
pp. 409-419 ◽  
Author(s):  
Angelo D. Moore ◽  
Jill B. Hamilton ◽  
George J. Knafl ◽  
P.A. Godley ◽  
William R. Carpenter ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Health Care ◽  
North Carolina ◽  
African American ◽  
Patient Satisfaction ◽  
Health Care Providers ◽  
African American Men ◽  
Care Providers ◽  
Patient Centered ◽  
The North

The purpose of this study was to determine if a particular set of health behaviors of health care providers and African American men (AAM) influence patient satisfaction from the AAM’s perspective. This descriptive, correlational study consisted of 505 AAM in North Carolina diagnosed with prostate cancer and enrolled in the North Carolina–Louisiana Prostate Cancer Project (PCaP). Analyses consisted of bivariate analyses and multiple regression. Patient-to-provider communication, interpersonal treatment, and provider-to-patient communication accounted for 45% ( p ≤ .0001) of the variability in patient satisfaction. Interpersonal treatment (provider focusing on the patient) explained the greatest amount ( F = 313.53, R2 = .39) of patient satisfaction. Since interpersonal treatment focuses on the patient and demonstrated to be the strongest predictor in patient satisfaction, it is noteworthy to consider the emphasis that should be placed on patient-centered care. In addition, knowing important variables positively affecting patient satisfaction provides useful information for developing appropriate interventions to improve AAM health care experiences.

Sign in / Sign up

Export Citation Format

Share Document