scholarly journals A Systematic Review and Meta-Analysis of the Efficacy of Evening Primrose Oil for Mastalgia Treatment

2021 ◽  
Vol 18 (12) ◽  
pp. 6295
Author(s):  
Lina Liana Ahmad Adni ◽  
Mohd Noor Norhayati ◽  
Ritzzaleena Rosli Mohd Rosli ◽  
Juliawati Muhammad
Keyword(s):  
Vitamin E ◽  
Meta Analysis ◽  
Similar Efficacy ◽  
Breast Pain ◽  
Evening Primrose Oil ◽  
Evening Primrose ◽  
Number Of Patients ◽  
Significant Impairment ◽  
Mean Differences ◽  
Topical Nsaids

Mastalgia, or breast pain, is common among women which can lead to significant impairment in daily living. Hence, finding an effective treatment that can alleviate the symptom is very important. Thus, we carry out this study to determine the efficacy of evening primrose oil (EPO) for mastalgia treatment in women. The review included published randomised clinical trials that evaluated EPO used for treating mastalgia against a placebo or other treatments, irrespective of the blinding procedure, publication status, or sample size. Two independent authors screened the titles and abstracts of the identified trials; full texts of relevant trials were evaluated for eligibility. Two reviewers independently extracted data on the methods, interventions, outcomes, and risk of bias. The random-effects model was used for estimating the risk ratios and mean differences with 95% confidence intervals. Thirteen trials with 1752 randomised patients were included. The results showed that EPO has no difference to reduce breast pain compared to topical NSAIDS, danazol, or vitamin E. The number of patients who achieved pain relief was no different compared to the placebo or other treatments. The EPO does not increase adverse events, such as nausea, abdominal bloating, headache or giddiness, increase weight gain, and altered taste compared to a placebo or other treatments. EPO is a safe medication with similar efficacy for pain control in women with mastalgia compared to a placebo, topical NSAIDS, danazol, or vitamin E.

scholarly journals Compare the effect of flaxseed, evening primrose oil and Vitamin E on duration of periodic breast pain

2017 ◽  
Vol 6 (1) ◽  
pp. 85 ◽  
Author(s):  
Elham Adibmoghaddam ◽  
Farzaneh Jaafarnejad ◽  
SeyyedAhmad Emami ◽  
Azadeh Saki
Keyword(s):  
Vitamin E ◽  
Breast Pain ◽  
Evening Primrose Oil ◽  
Evening Primrose

scholarly journals 109 Comparative Efficacy and Tolerability of Lurasidone Versus Other Oral Atypical Antipsychotics for Pediatric Schizophrenia: A Network Meta Analysis

CNS Spectrums ◽  
2018 ◽  
Vol 23 (1) ◽  
pp. 70-71
Author(s):  
Celso Arango ◽  
Daisy Ng-Mak ◽  
Elaine Finn ◽  
Aidan Byrne ◽  
Krithika Rajagopalan ◽  
...  
Keyword(s):  
Weight Gain ◽  
Atypical Antipsychotics ◽  
Meta Analysis ◽  
Credible Interval ◽  
Similar Efficacy ◽  
Binary Outcomes ◽  
Trial Duration ◽  
Study Objective ◽  
Syndrome Scale ◽  
Mean Differences

AbstractStudy ObjectiveThis analysis assessed the relative efficacy and tolerability of lurasidone versus other atypical antipsychotics in the treatment of pediatricschizophrenia.MethodsA systematic literature review identified 13 randomized-controlled trials for the treatment of pediatric schizophrenia. A Bayesian network meta-analysis compared the efficacy and tolerability of the following atypical antipsychotics: aripiprazole, asenapine, clozapine, lurasidone, olanzapine, paliperidone, quetiapine, risperidone, andziprasidone. Patients were 7-17 years old and trial duration ranged from 6-12 weeks. Outcomes included Positive and Negative Syndrome Scale (PANSS), Clinical Global Impressions-Severity (CGI-S), weight gain, all-cause treatment discontinuation, and extrapyramidal symptoms. Results from the fixed effect models were reported as mean differences for continuous outcomes and odds ratios for binary outcomes; each with a 95% credible interval.ResultsLurasidone had significantly greater improvement compared with placebo for PANSS (-7.95 [-11.76, -4.16]) and CGI-S (-0.44 [-0.67, -0.22]), but did not differ from comparators. The differences in weight gain for lurasidone relative to comparators were as follows: clozapine (-3.81kg [-8.03, 0.42]), olanzapine (-3.62kg [-4.84, -2.41]), quetiapine (-2.13kg [-3.20, -1.08]), risperidone (-1.16kg [-2.14, -0.17]), asenapine (-0.98kg [-1.71, -0.24]), paliperidone (-0.85kg [-1.57, -0.14]), aripiprazole (-0.15kg [-0.88, 0.58]), and ziprasidone (0.38kg [-0.49, 1.24]); all were statistically significant except for clozapine, aripiprazole, and ziprasidone. Rates of all-cause discontinuation andextrapyramidal symptoms were similar for lurasidone and comparators, except aripiprazole and paliperidone, which had higher rates of all-cause discontinuation.ConclusionsIn this network meta-analysis of atypical antipsychotics for the treatment of adolescent schizophrenia, lurasidone was associated with similar efficacy, but less weight gain than active comparators.Funding AcknowledgementsThis study was funded by Sunovion Pharmaceuticals Inc.

Dietary fish and evening primrose oil with vitamin E effects on semen variables in cockerels

2005 ◽  
Vol 46 (2) ◽  
pp. 214-222 ◽  
Author(s):  
S. Cerolini ◽  
P.F. Surai ◽  
B.K. Speake ◽  
N.H.C. Sparks
Keyword(s):  
Vitamin E ◽  
Evening Primrose Oil ◽  
Evening Primrose ◽  
Dietary Fish

Effect of evening primrose oil supplementation on lipid profile: A systematic review and meta‐analysis of randomized clinical trials

2020 ◽  
Vol 34 (10) ◽  
pp. 2628-2638
Author(s):  
Masoud Khorshidi ◽  
Meysam Zarezadeh ◽  
Omid Moradi Moghaddam ◽  
Mohammad Reza Emami ◽  
Hamed Kord‐Varkaneh ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Lipid Profile ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Evening Primrose Oil ◽  
Evening Primrose

scholarly journals A comparative study of centchroman versus evening primrose oil in treatment of mastalgia

2020 ◽  
Vol 8 (1) ◽  
pp. 331
Author(s):  
Anmol Singh Ahluwalia ◽  
Pradeep Bhatia ◽  
Anmol Sanjay Chhabra
Keyword(s):  
Menstrual Cycle ◽  
Breast Pain ◽  
Evening Primrose Oil ◽  
Pharmacological Agents ◽  
Evening Primrose ◽  
Time Period ◽  
General Surgeons ◽  
Cyclical Mastalgia ◽  
Economical Alternative

Background: Breast pain or mastalgia is one of the most common symptoms presenting to general surgeons. Approximately 60-70% of the women experience some type of breast pain at some point of their lives. Mastalgia may be classified as cyclical and non-cyclical.  In cyclical mastalgia the pain intensity is changing during the menstrual cycle. In non-cyclical mastalgia there is no other obvious cause present, the pain is considered to be originating from the breast and the pain remains unchanged during the menstrual cycle. If the pain persists there are a variety of pharmacological agents for treatment of mastalgia. These include 3-6 months course of low dose tamoxifen (10 mg) or evening primrose oil. Other agents include bromocriptine and danazol but are obsolete now days. Newer treatments include centchroman and topical non-steroidal anti-inflammatory preparations. In pursuit of finding an effective safe and economical agent to treat it, plan to compare centchroman to evening primrose oil as treatment of mastalgia.Methods: In this study, two groups with 40 patients each will be taken and treatment will be given for 12 weeks and follow up to 24 weeks will be done without medication to assess sustained response or recurrence of mastalgia.Results: Centchroman is a non-steroidal drug found to be effective in the treatment of mastalgia with early and better relief in a time period of 3 months with minimal side effects as compared to evening primrose oil.Conclusions: This study has demonstrated that Centchroman therapy offers safe, effective and economical alternative to Evening Primrose oil for treatment of mastalgia.

Preoperative and intraoperative risk factors of postoperative pancreatic fistula after pancreaticoduodenectomy – systematic review and meta-analysis

2021 ◽  
Vol 93 (6) ◽  
pp. 1-10
Author(s):  
Kajetan Kiełbowski ◽  
Estera Bakinowska ◽  
Rafał Uciński
Keyword(s):  
Risk Factors ◽  
Pancreatic Fistula ◽  
Meta Analysis ◽  
Significant Risk ◽  
Postoperative Pancreatic Fistula ◽  
Pancreatic Anastomosis ◽  
Pancreatic Fat ◽  
Number Of Patients ◽  
Potential Risk Factors ◽  
Mean Differences

Introduction: Postoperative pancreatic fistula (POPF) is a potentially life-threatening complication after pancreaticoduodenectomy (PD). It is observed when the amylase activity in the drain fluid exceeds three times the normal upper value. Grades B and C of POPF are considered as clinically relevant. Fistula might originate due to failure of healing of a pancreatic anastomosis or from raw pancreatic surface. Materials and methods: 18 retrospective and prospective studies published between 2015 and 2020 were included in this meta-analysis. Total number of patients was 5836. To investigate potential risk factors associated with the occurrence of POPF, odds ratios (OR) with 95% confidence intervals (CI) were calculated. To compare discontinuous data, mean differences (MD) were calculated. Results: 13 factors were divided into preoperative and intraoperative groups. Male sex, higher BMI, soft pancreatic texture and small pancreatic duct were considered as significant risk factors while vascular resection lowered the risk of development pancreatic fistula. Discussion: It is considered that the development of POPF is associated with intrapancreatic fat. More severe infiltration with fat tissue is responsible for soft texture of the gland, while higher BMI is one of the risk factors of increased pancreatic fat. On the contrary, diabetes is associated with fibrotic pancreas which could lower the risk of developing POPF.

Effects of the Mixture of Vitamin C, Vitamin E, Pycnogenol and Evening Primrose Oil on the UV-Induced Pigmentation and Wrinkle Reductions in Human Skin

2009 ◽  
Vol 42 (6) ◽  
pp. 516 ◽  
Author(s):  
Min-Youl Chang ◽  
Sang-Ki Park ◽  
Taek-Jong Kwak ◽  
Hyoung-Kook Park ◽  
Cheon-Koo Lee ◽  
...  
Keyword(s):  
Vitamin E ◽  
Vitamin C ◽  
Human Skin ◽  
Evening Primrose Oil ◽  
Evening Primrose
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