scholarly journals Microbial Polymers as Sustainable Agents for Mitigating Health Risks of Plant-Based Endocrine Disruptors in Surface Water

2021 ◽  
Vol 18 (19) ◽  
pp. 10040
Author(s):  
Moushumi Ghosh ◽  
Krishnaswamy Balamurugan ◽  
Vivek Sharma
Keyword(s):  
Endocrine Disruptors ◽  
Potential Role ◽  
Developmental Toxicity ◽  
Egg Laying ◽  
Biochanin A ◽  
Egg Viability ◽  
Adsorption Data ◽  
Study Offer ◽  
Maximum Removal

This study investigated the binding abilities of extracellular polymers produced by an environmentally isolated strain of Enterococcus hirae towards phytoestrogen endocrine disruptors—biochanin A, formonetin, genistein and daidzein. The extracellular biopolymer exhibited notable binding and removal for all four phytoestrogens, with a maximum removal of daidzein (87%) followed by genistein (72%) at a 1–1.5 mg/mL concentration. Adsorption proceeded rapidly at ambient temperature. The adsorption data fitted well with the Langmuir isotherm. Based on the adsorption energy, the biopolymer binding of phytoestrogens was inferred as daidzein > genistein > biochanin A > formononetin. Toxicity of the biopolymer (5–250 µg/mL) evaluated using RAW 264.7 cell lines indicated no significant (p < 0.05) changes in viability. In biopolymer-challenged Caenorhabditis elegans previously exposed to daidzein, complete protection to developmental toxicity, such as reduced egg-laying capacity, egg viability and progeny counts of the worm, was observed. The results of this study offer valuable insights into understanding the potential role of microbial extracellular biopolymers in binding and removal of phytoestrogens with sustainable technological implications in modulating the toxic effect of high levels of endocrine disruptors in the environment.

scholarly journals Triphenyl phosphate-induced developmental toxicity in zebrafish: Potential role of the retinoic acid receptor

2015 ◽  
Vol 161 ◽  
pp. 221-230 ◽  
Author(s):  
Gregory M. Isales ◽  
Rachel A. Hipszer ◽  
Tara D. Raftery ◽  
Albert Chen ◽  
Heather M. Stapleton ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Potential Role ◽  
Retinoic Acid Receptor ◽  
Developmental Toxicity ◽  
Triphenyl Phosphate ◽  
Acid Receptor

Potential role of oxidative damage in developmental toxicity of arsenic

Arsenic ◽  
1997 ◽  
pp. 135-144 ◽  
Author(s):  
S. Tabacova ◽  
E. S. Hunter ◽  
L. Balabaeva
Keyword(s):  
Oxidative Damage ◽  
Potential Role ◽  
Developmental Toxicity

scholarly journals Developmental toxicity of the PBDE metabolite 6-OH-BDE-47 in zebrafish and the potential role of thyroid receptor β

2015 ◽  
Vol 168 ◽  
pp. 38-47 ◽  
Author(s):  
Laura J. Macaulay ◽  
Albert Chen ◽  
Kylie D. Rock ◽  
Laura V. Dishaw ◽  
Wu Dong ◽  
...  
Keyword(s):  
Potential Role ◽  
Developmental Toxicity ◽  
Thyroid Receptor

scholarly journals Environmental Contaminants Acting as Endocrine Disruptors Modulate Atherogenic Processes: New Risk Factors for Cardiovascular Diseases in Women?

Biomolecules ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 44
Author(s):  
Silvia Migliaccio ◽  
Viviana M. Bimonte ◽  
Zein Mersini Besharat ◽  
Claudia Sabato ◽  
Andrea Lenzi ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Endocrine Disruptors ◽  
Successful Aging ◽  
Molecular Mechanisms ◽  
Potential Role ◽  
Unhealthy Lifestyle ◽  
Age Related ◽  
Increased Risk ◽  
Artery Disease

The number of aged individuals is increasing worldwide, rendering essential the comprehension of pathophysiological mechanisms of age-related alterations, which could facilitate the development of interventions contributing to “successful aging” and improving quality of life. Cardiovascular diseases (CVD) include pathologies affecting the heart or blood vessels, such as hypertension, peripheral artery disease and coronary heart disease. Indeed, age-associated modifications in body composition, hormonal, nutritional and metabolic factors, as well as a decline in physical activity are all involved in the increased risk of developing atherogenic alterations that raise the risk of CVD development. Several factors have been reported to play a role in the alterations observed in muscle and endothelial cells and that lead to increased CVD, such as genetic pattern, smoking and unhealthy lifestyle. Moreover, a difference in the risk of these diseases in women and men has been reported. Interestingly, in the past decades attention has been focused on a potential role of several pollutants that disrupt human health by interfering with hormonal pathways, and more specifically in non-communicable diseases such as obesity, diabetes and CVD. This review will focus on the potential alteration induced by Endocrine Disruptors (Eds) in the attempt to characterize a potential role in the cellular and molecular mechanisms involved in the atheromatous degeneration process and CVD progression.

POPDC proteins and cardiac function

2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand
Keyword(s):  
Potential Role ◽  
Striated Muscle ◽  
Short Review ◽  
Effector Proteins ◽  
Muscle Disease ◽  
Disease Genes ◽  
Protein Protein Interaction ◽  
Interaction Partners ◽  
And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

The Effect of Path Length and Display Size on Memory for Spatial Information

2012 ◽  
Vol 59 (3) ◽  
pp. 147-152 ◽  
Author(s):  
Katherine Guérard ◽  
Sébastien Tremblay
Keyword(s):  
Path Length ◽  
Potential Role ◽  
Spatial Information ◽  
Recall Performance ◽  
Minor Role ◽  
Length Effect ◽  
Serial Memory ◽  
Fixed Reference ◽  
A Minor

In serial memory for spatial information, some studies showed that recall performance suffers when the distance between successive locations increases relatively to the size of the display in which they are presented (the path length effect; e.g., Parmentier et al., 2005) but not when distance is increased by enlarging the size of the display (e.g., Smyth & Scholey, 1994). In the present study, we examined the effect of varying the absolute and relative distance between to-be-remembered items on memory for spatial information. We manipulated path length using small (15″) and large (64″) screens within the same design. In two experiments, we showed that distance was disruptive mainly when it is varied relatively to a fixed reference frame, though increasing the size of the display also had a small deleterious effect on recall. The insertion of a retention interval did not influence these effects, suggesting that rehearsal plays a minor role in mediating the effects of distance on serial spatial memory. We discuss the potential role of perceptual organization in light of the pattern of results.

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