scholarly journals Utility of Self-Reported Heat Stress Symptoms and NGAL Biomarker to Screen for Chronic Kidney Disease of Unknown Origin (CKDu) in Sri Lanka

2021 ◽  
Vol 18 (19) ◽  
pp. 10498
Author(s):  
Pavithra N. Kulasooriya ◽  
Kithsiri B. Jayasekara ◽  
Thilini Nisansala ◽  
Sajani Kannangara ◽  
Ranawaka Karunarathna ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Acute Kidney Injury ◽  
Heat Stress ◽  
Sri Lanka ◽  
Kidney Disease ◽  
Kidney Injury ◽  
Agricultural Workers ◽  
Endemic Region ◽  
Stress Symptoms ◽  
Urine Markers

Objective. We examined heat stress symptoms and urine markers of chronic kidney disease (CKDu) in Sri Lanka to assess differences between endemic vs. non-endemic regions and by occupation. Sample and Methods. We assessed a total of 475 villagers. In the endemic region, 293 were agricultural workers and 67 were not working primarily in agriculture. In the non-endemic region, 76 were agricultural workers. Of the residents, 218 were assessed for neutrophil gelatinase-associated lipocalin (NGAL), an early predictor of acute kidney injury, along with urine markers of chronic kidney disease. Results. The mean (sd) age of the sample was 45.2 (12.6), with males comprising 52.7%; 7.2% reported kidney disease (n = 34), and 5.7% reported diabetes (n = 27). The heat stress index (mean (sd)) was highest among agricultural workers in the endemic region (8.05 (5.9)), intermediate in non-agricultural workers in the endemic region (4.61 (4.5)), and lowest among agricultural workers in the non-endemic region (3.85 (3.3)); p < 0.0001. Correlations were higher between NGAL and serum microalbumin in the endemic agricultural worker sample than in the other two samples (Spearman’s r = 0.34 vs. 0.15 and 0.20). Conclusions. Both heat stress symptoms and NGAL values were higher among agricultural workers in endemic CKDu regions. Correlations between NGAL and microalbumin suggested a link between acute kidney injury and chronic kidney disease in the more-exposed sample.

scholarly journals Climatological Nephropathy: An Overview

2021 ◽  
Vol 11 (9) ◽  
pp. 83-96
Author(s):  
Priya Jaswal ◽  
Priyanka . ◽  
Jhilli Basu
Keyword(s):  
Chronic Kidney Disease ◽  
Acute Kidney Injury ◽  
Heat Stress ◽  
Kidney Disease ◽  
Heat Waves ◽  
Kidney Injury ◽  
The Body ◽  
Mitigating Factors ◽  
The Government ◽  
Thermoregulatory Function

Globally hike in temperature provokes the heat waves, results in heat stress and becomes a silent health peril to the existing population. Today, heat stress or climatological stress is one of the dominant pathological conditions which comes in focus when the body means of handling its thermoregulatory function starts to fail, show its associated symptoms followed by eventual loss of consciousness and finally death. The condition of heat stress along with intermittent dehydration worsens the renal damage and enhances the risk of Acute Kidney Injury (AKI), results in chronic kidney disease (CKD). Therefore, CKD comes up as a leading cause of death, specifically in those patients having long-lasting medical conditions like heart problem, hypertension, diabetes and obesity etc. High temperature, work rate, humidity and working time wearing accessories, all become mitigating factors for causing heat stress. Distinguish molecular ups and downs specifically decrease production of uric acid (polyol-fructokinase pathway), increase ROS (oxidative stress), intracellular Ca2+ overload (mitochondrial dysfunctioning) and decrease NO (vascular endothelial dysfunctioning) has been responsible for the severe outcomes of Climatological Nephropathy (CN) or Heat Stress Nephropathy (HSN). However, prevention is the best approach to dealing with heat-related illness, therefore, the Government established some valuable policies as a preventive measures. This review epitomizes the alarming outcomes of the heat stress followed by recurrent dehydration and also enlightened the global talk of HSN, pathogenicity, molecular level peculiarities and recommended measures for HSN. Key words: Acute Kidney Injury, Chronic Kidney Disease, Nephropathy, Mitochondrial Dysfunctioning.

Chronic kidney disease in snake envenomed patients with acute kidney injury in Sri Lanka: a descriptive study

2012 ◽  
Vol 88 (1037) ◽  
pp. 138-142 ◽  
Author(s):  
H M N J Herath ◽  
A W M Wazil ◽  
D T D J Abeysekara ◽  
N D C Jeewani ◽  
K G A D Weerakoon ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Acute Kidney Injury ◽  
Sri Lanka ◽  
Kidney Disease ◽  
Kidney Injury ◽  
Descriptive Study

scholarly journals Postoperative acute kidney injury in adult non-cardiac surgery: joint consensus report of the Acute Disease Quality Initiative and PeriOperative Quality Initiative

2021 ◽  
Author(s):  
John R. Prowle ◽  
Lui G. Forni ◽  
Max Bell ◽  
Michelle S. Chew ◽  
Mark Edwards ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Kidney Disease ◽  
Kidney Injury ◽  
Adverse Outcomes ◽  
Baseline Risk ◽  
Major Surgery ◽  
Increased Risk

AbstractPostoperative acute kidney injury (PO-AKI) is a common complication of major surgery that is strongly associated with short-term surgical complications and long-term adverse outcomes, including increased risk of chronic kidney disease, cardiovascular events and death. Risk factors for PO-AKI include older age and comorbid diseases such as chronic kidney disease and diabetes mellitus. PO-AKI is best defined as AKI occurring within 7 days of an operative intervention using the Kidney Disease Improving Global Outcomes (KDIGO) definition of AKI; however, additional prognostic information may be gained from detailed clinical assessment and other diagnostic investigations in the form of a focused kidney health assessment (KHA). Prevention of PO-AKI is largely based on identification of high baseline risk, monitoring and reduction of nephrotoxic insults, whereas treatment involves the application of a bundle of interventions to avoid secondary kidney injury and mitigate the severity of AKI. As PO-AKI is strongly associated with long-term adverse outcomes, some form of follow-up KHA is essential; however, the form and location of this will be dictated by the nature and severity of the AKI. In this Consensus Statement, we provide graded recommendations for AKI after non-cardiac surgery and highlight priorities for future research.

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