Analysis of Histopathological Findings of Lung Carcinoma in Czech Black Coal Miners in Association with Coal Workers’ Pneumoconiosis

Coal miners with coal workers’ pneumoconiosis (CWP, J60 according to ICD-10) were previously found to have a significantly higher risk of lung carcinoma compared to the general male population. The presented study aimed to analyze the (i) incidence of lung carcinoma in miners, (ii) histopathological findings in cohorts with and without CWP, and (iii) effect of smoking cessation on the histopathological profile. Analyzed cohorts consisted of miners with (n = 3476) and without (n = 6687) CWP. Data on personal and working history obtained from the medical records were combined with information on lung cancer from the Czech Oncological Register and histopathological findings. Statistical analysis was performed using non-parametric tests and the incidence risk ratio at the significance level of 5%. In 1992–2015, 180 miners (2.7%) without CWP and 169 (4.9%) with CWP, respectively, were diagnosed with lung carcinoma. The risk of lung cancer in miners with CWP was 1.82 (95% CI: 1.48–2.25) times higher than in those without CWP. Squamous cell carcinoma (37%) was the most common histopathological type, followed by adenocarcinoma (22%) and small cell carcinoma (21%). A statistically significant difference between the cohorts (p = 0.003) was found in the histopathological subtypes, with the incidence of small cell carcinoma being 2 times higher in miners without CWP than in those with CWP. Only a few individuals with lung carcinoma were non-smokers. The incidence of small cell carcinoma, which is strongly associated with smoking, is significantly higher in miners without CWP. Smoking constitutes the most important risk factor for developing lung carcinoma even in that cohort. However, CWP remains a very important risk factor.

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Type and mode of diagnosis of carcinoma lung in a tertiary care centre: one year experience

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20174940 ◽

2017 ◽

Vol 5 (11) ◽

pp. 4891

Author(s):

Jayaprakash Balakrishnan ◽

Sindhu Nair Prasannakumari ◽

Ajith Achuthan ◽

John Mathew

Keyword(s):

Lung Cancer ◽

Cell Carcinoma ◽

Small Cell Carcinoma ◽

Tertiary Care ◽

Small Cell ◽

Common Type ◽

Ultra Sound ◽

Tertiary Care Centre ◽

Easy Method ◽

One Year

Background: Lung cancer is one of the commonest cancers and cause of cancer related deaths all over the world. The reported incidence of adenocarcinoma is increasing globally and now reported to be the most common type of lung cancer. A panel of investigations are used for the diagnosis of lung cancer. Hence a study was planned to find out the pattern of malignancy and the most appropriate investigation for diagnosis. Objective of present study was to find out the type of carcinoma lung and to find out the best and easy method for diagnosis of carcinoma lung in a tertiary care centre.Methods: A hospital based cross sectional study was conducted in one unit of the Department of Pulmonary Medicine, Government Medical college, Thiruvananthapuram for a period of one year.148 diagnosed cases of carcinoma lung were enrolled. The type and the methods used for diagnosis were analysed.Results: Adenocarcinoma was the commonest malignancy 57 (38.5%), followed by squamous cell carcinoma 44 (29.7%) and small cell carcinoma 10 (6.75%). Rest of the cases 37 (25%) include non small cell carcinoma, poorly differentiated carcinoma and lymphoma. Diagnosis was established by FNA Lung in 46 (31.1%) patients and bronchoscopy and biopsy in 41 (27.7%). Other methods include TBNA 12 (8.1%), lymph node FNA/biopsy 11 (7.4%), pleural fluid cytology 24 (16.2%), sputum cytology and tru cut biopsy 14 (9.5%).Conclusions: The most common type of lung malignancy in present study was adenocarcinoma. Ultra sound guided FNAC lung and bronchoscopy biopsy were the best methods in present study to confirm the diagnosis.

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Establishment and characterisation of cell lines from patients with lung cancer (predominantly small cell carcinoma)

Lung Cancer ◽

10.1016/s0169-5002(86)80706-1 ◽

1986 ◽

Vol 2 (4) ◽

pp. 253

Keyword(s):

Lung Cancer ◽

Cell Carcinoma ◽

Cell Lines ◽

Small Cell Carcinoma ◽

Small Cell

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Ghrelin and cortistatin in lung cancer: Expression of peptides and related receptors in human primary tumors and in vitro effect on the H345 small cell carcinoma cell line

Journal of Endocrinological Investigation ◽

10.1007/bf03347371 ◽

2006 ◽

Vol 29 (9) ◽

pp. 781-790 ◽

Cited By ~ 36

Author(s):

P. Cassoni ◽

E. Allia ◽

T. Marrocco ◽

C. Ghè ◽

E. Ghigo ◽

...

Keyword(s):

Lung Cancer ◽

Cell Carcinoma ◽

Cell Line ◽

Small Cell Carcinoma ◽

Carcinoma Cell ◽

Small Cell ◽

Carcinoma Cell Line ◽

Primary Tumors ◽

Vitro Effect

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Levels of Complement Regulatory Molecules in Lung Cancer: Disappearance of the D17 Epitope of CD55 in Small-cell Carcinoma

Japanese Journal of Cancer Research ◽

10.1111/j.1349-7006.1993.tb02040.x ◽

1993 ◽

Vol 84 (7) ◽

pp. 753-759 ◽

Cited By ~ 17

Author(s):

Takahiko Sakuma ◽

Ken Kodama ◽

Tomoko Kara ◽

Yoshimi Eshita ◽

Nobuhiko Shibata ◽

...

Keyword(s):

Lung Cancer ◽

Cell Carcinoma ◽

Small Cell Carcinoma ◽

Small Cell

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Pathological analysis of hesperetin-derived small cell lung cancer by artificial intelligence technology under fiberoptic bronchoscopy

Mathematical Biosciences and Engineering ◽

10.3934/mbe.2021423 ◽

2021 ◽

Vol 18 (6) ◽

pp. 8538-8558

Author(s):

Xiaoli Zhang ◽

◽

Ziying Yu ◽

Keyword(s):

Artificial Intelligence ◽

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Carcinoma ◽

Small Cell Carcinoma ◽

Cell Lung Cancer ◽

Fiberoptic Bronchoscopy ◽

Small Cell ◽

Small Cell Lung ◽

Artificial Intelligence Technology

<abstract> <p>Lung cancer is one of the most common tumors. There are 1.8 million new cases worldwide each year, accounting for about 13% of all new tumors. Lung cancer is the most important cause of cancer-related deaths. 1.4 million people die of lung cancer each year. This article uses artificial intelligence technology to analyze the pathology of hesperetin-derived small cell lung cancer under fiberoptic bronchoscopy. This article takes 48 lung slice samples as the research object. Among them, 36 cases of lung small cell carcinoma have history slices from Lhasa City Institute of Biology, the patient has complete cases, and the other 12 normal lung slices come from Xinjiang Biotechnology Laboratory. In this paper, the above-mentioned 36 lung cancer slices became the study group, and 12 normal slices became the reference group. This article presents a method for hesperetin-fiber bronchoscope to study the pathological mechanism of lung small cell carcinoma (H-FBS), which is used to study slices. The above-mentioned 48 samples were taken for slice observation. First, the 48 slices were technically tested by artificial intelligence fiber bronchoscope combined with hesperetin derivatives, and then the slice observation results were verified by CTC technology. In addition, in each step, the C5orf34 in the tissue is detected separately, which is beneficial to adjust the content of C5orf34 so that the treatment of lung cancer can control the development of lung cancer under fiberoptic bronchoscopy. Experimental results show that the diagnostic accuracy rate of this method is 97.9%, which is higher than that of lung biopsy (89%); compared with multiple CTC detection, the cost is low and the time is shor.</p> </abstract>

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A Case of Small Cell Carcinoma of Lung Presenting as Opaque Hemithorax

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2020/45825.14120 ◽

2020 ◽

Author(s):

Keerthan Ganapathi ◽

Saood Ali ◽

Ulhas Jadhav ◽

Babaji Ghewade

Keyword(s):

Lung Cancer ◽

Pleural Effusion ◽

Cell Carcinoma ◽

Small Cell Carcinoma ◽

Small Cell ◽

Tobacco Smoke Exposure ◽

Opaque Hemithorax ◽

Contrast Enhanced ◽

Enhanced Computed Tomography

The most common cause of an Opaque Hemithorax is Pleural Effusion. It is a rare occurrence to find patients with extensive mass leading to an opaque hemithorax. Thorough search of literature did not yield any case with such a large lung mass leading to opaque hemithorax, without the presence of pleural effusion. Lung cancer is the most common cancer diagnosed worldwide and has predominantly been attributed to tobacco smoke exposure. Of the several types, small cell lung cancer differs from others by its early spread and extensive dissemination leading to metastatic classification at the time of diagnosis. Here, is a case of a 50-year-old female patient who presented to the outpatient department with dry cough, weight loss and appetite loss since five months. Her chest radiograph revealed a right-sided homogeneous opacity involving the entire right hemithorax and left-sided pleural-based homogenous mass. Contrast Enhanced Computed Tomography (CECT) thorax revealed an enlarged hemithorax with evidence of large, ill-defined heterogeneously enhancing multilobulated soft-tissue density mass lesion occupying the entire right hemithorax. Biopsy was suggestive of Small Cell Carcinoma of Lung (SCLC), chemotherapy was given and patient is under regular follow-up.

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Changing trends in incidence of lung cancer by histological type in Montenegro

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh1402023m ◽

2014 ◽

Vol 142 (1-2) ◽

pp. 23-28

Author(s):

Milic Medenica ◽

Miras Medenica ◽

Olivera Bojovic ◽

Ivan Soldatovic ◽

Ivana Durutovic

Keyword(s):

Lung Cancer ◽

Squamous Cell Carcinoma ◽

Small Cell Lung Cancer ◽

Cell Carcinoma ◽

Small Cell Carcinoma ◽

Squamous Cell ◽

Cell Lung Cancer ◽

Small Cell ◽

Histological Type ◽

Small Cell Lung

Introduction. Lung cancer is one of the most common malignant neoplasms, as well as the most common cause of death cancer. Most lung cancers are squamous cell carcinomas, small cell carcinomas or adenocarcinomas. Objective. Examining changes in trends of lung cancer incidence in Montenegro by histological type during a 15-year period, from 1997 to 2011. Methods. During the study period, histopathological confirmation was obtained for all primary lung cancer cases in the only hospital for lung diseases in the country. Based on the data from medical records, patients were classified by time period, sex, age groups and smoking history. Descriptive method was used. Results. Ratio between incidences of adenocarcinoma and squamous cell carcinoma changes in males, with a significant increase in the incidence rate of adenocarcinoma and drop in the rate of squamous cell carcinoma (p<0.001). In addition, statistically significant (p<0.05) decrease in the incidence of NSCLC (non-small cell lung cancer) and an increase in the incidence of SCLC (small cell lung cancer) was found. A statistically significant increase in linear trend in the incidence of small cell carcinoma was noted in females (p<0.005). Conclusion. Incidence rates of adenocarcinoma and small cell carcinoma have increased during the study period.

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Case Report: Hyponatremia of malignancy – An alternative mechanism? Syndrome of inappropriate atrial natriuretic peptide (SIANP)

F1000Research ◽

10.12688/f1000research.4950.2 ◽

2014 ◽

Vol 3 ◽

pp. 195

Author(s):

Steven Elias Mansoor ◽

David I Kagen ◽

Devan Kansagara

Keyword(s):

Lung Cancer ◽

Atrial Natriuretic Peptide ◽

Cell Carcinoma ◽

Natriuretic Peptide ◽

Small Cell Carcinoma ◽

Hormone Secretion ◽

Small Cell ◽

Fluid Restriction ◽

Alternative Mechanism ◽

Atrial Natriuretic

Euvolemic hyponatremia in the setting of lung cancer is most commonly due to the syndrome of inappropriate anti-diuretic hormone secretion (SIADH). However, a subset of patients with small cell carcinoma and hyponatremia also have elevated levels of atrial natriuretic peptide (ANP), which is produced by some small cell tumors. We report the case of a 64-year-old man with a limited-stage small cell carcinoma of the lung undergoing chemoradiation therapy, who was admitted to hospital with a pulmonary embolism. Two months earlier, at the time of diagnosis with lung cancer, he had a hypotonic, euvolemic hyponatremia, presumed to be caused by SIADH. At that time, his serum sodium readily normalized with fluid restriction and ADH-antagonist therapy with demeclocycline. However, during his second admission, the hyponatremia was refractory to treatment: his sodium level slowly declined from 138 mmol/L to a nadir of 118 mmol/L, despite early initiation of fluid restriction and maximal doses of demeclocycline. Laboratory values revealed a low but inappropriately non-zero level of ADH but also an inappropriately low level of aldosterone and an elevated level of ANP, suggesting that SIADH might not be the only contributor to the hyponatremia. While a causal link between ectopic ANP production and hyponatremia has never been established, an inappropriately high level of ANP can directly decrease sodium re-absorption in the proximal convoluted tubule of the kidney and increase glomerular filtration rate (GFR), resulting in greater excretion of sodium and water. In addition, high circulating levels of ANP can inhibit aldosterone secretion, potentially resulting in further sodium wasting. Here, the elevated ANP and inappropriately low aldosterone suggested the possibility that the refractory hyponatremia, although initiated by SIADH, was further worsened by an ANP-mediated natriuresis and suppression of aldosterone response.

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