scholarly journals Vitamin D-Related Gene Polymorphisms, Plasma 25-Hydroxy-Vitamin D, Cigarette Smoke and Non-Small Cell Lung Cancer (NSCLC) Risk

2016 ◽  
Vol 17 (10) ◽  
pp. 1597 ◽  
Author(s):  
Xiayu Wu ◽  
Jiaoni Cheng ◽  
Kaiyun Yang
Keyword(s):  
Lung Cancer ◽  
Vitamin D ◽  
Small Cell Lung Cancer ◽  
Cigarette Smoke ◽  
Cell Lung Cancer ◽  
Gene Polymorphisms ◽  
Small Cell ◽  
Related Gene ◽  
Small Cell Lung ◽  
25 Hydroxy Vitamin D

scholarly journals Associations between ABCG2 gene polymorphisms and gefitinib toxicity in non-small cell lung cancer: a meta-analysis

2018 ◽  
Vol Volume 11 ◽  
pp. 665-675 ◽  
Author(s):  
Lina Tang ◽  
Chunling Zhang ◽  
Hairong He ◽  
Zhenyu Pan ◽  
Di Fan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Small Cell ◽  
Small Cell Lung ◽  
Abcg2 Gene

scholarly journals STAT3 gene polymorphisms and susceptibility to non-small cell lung cancer

2011 ◽  
Vol 10 (3) ◽  
pp. 1856-1865 ◽  
Author(s):  
B. Jiang ◽  
Z.Z. Zhu ◽  
F. Liu ◽  
L.J. Yang ◽  
W.Y. Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Gene Polymorphisms ◽  
Small Cell ◽  
Small Cell Lung

scholarly journals miRNA and proteomic dysregulation in non-small cell lung cancer in response to cigarette smoke

2017 ◽  
Vol 1 (Special Issue-Supplement) ◽  
pp. 244-244
Author(s):  
Niraj Babu ◽  
Jayshree Advani ◽  
Hitendra S. Solanki ◽  
Krishna Patel ◽  
Ankit Jain ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cigarette Smoke ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung

Cigarette Smoke-Induced Reduction of 14-3-3σ Expression Promotes The Progression of Non-Small Cell Lung Cancer

2021 ◽  
Author(s):  
Longxia Dai ◽  
Quanwen Deng ◽  
Aibin Liu ◽  
Shuya He ◽  
Qiong Chen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Protein Expression ◽  
Small Cell Lung Cancer ◽  
Cigarette Smoke ◽  
Cell Lung Cancer ◽  
A549 Cells ◽  
Small Cell ◽  
Small Cell Lung ◽  
Smoking Group ◽  
The Relationship

Abstract Background Lung cancer is a common malignant tumour and the leading cause of cancer death. Smoking is closely related to lung cancer, which can not only induce the occurrence of lung cancer but also affect its progress and prognosis. Objectives To investigated the relationship between smoking and 14-3-3σ protein expression in non-small-cell lung cancer (NSCLC), investigated the relationship between 14-3-3σ expression and cell migration in A549 cells induced by cigarette smoke extract (CSE) and explored whether DNA methylation plays a role in the decreased expression of 14-3-3σ induced by CSE. Methods 14-3-3σ protein expression was examined by immunohistochemistry in 152 NSCLC tissue samples. In vitro experiments were divided into three groups: The current smoking group (CS), the ex-smoking group (ES) and the normal control group (NC). Cell transfection was used for 14-3-3σ protein overexpression. The mRNA and protein expression levels of 14-3-3σ were detected by RT-PCR and Western blotting, respectively. Cell migration was detected by Transwell and wound-healing assays, and the methylation of 14-3-3σ was detected by methylation-specific PCR. Results 14-3-3σ protein expression was decreased in NSCLC patients with a history of smoking. The expression of 14-3-3σ was decreased in A549 cells treated with CSE. The migration capacity of A549 cells treated with CSE was enhanced. DNA methylation in the cigarette smoke-treated A549 cells was higher than that in the untreated cells. Conclusion Cigarette smoke induced reduction of 14-3-3σ expression can promote the progression of non-small cell lung cancer.

scholarly journals Genetic Polymorphisms in the Vitamin D Pathway and Non-small Cell Lung Cancer Survival

2019 ◽  
Vol 26 (3) ◽  
pp. 1709-1715 ◽  
Author(s):  
Jinyu Kong ◽  
Xiaojie Chen ◽  
Jian Wang ◽  
Jingxin Li ◽  
Fangxiu Xu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Vitamin D ◽  
Small Cell Lung Cancer ◽  
Genetic Polymorphisms ◽  
Cell Lung Cancer ◽  
Cancer Survival ◽  
Cancer Susceptibility ◽  
Small Cell ◽  
Nucleotide Polymorphisms ◽  
Small Cell Lung

Abstract Various genetic polymorphisms have been linked to lung cancer susceptibility and survival outcomes. Vitamin D (VD) regulates cell proliferation and differentiation, inhibits tumor growth and induces apoptosis. Observations from several previous studies including our own suggest that genetic polymorphisms in the VD pathway may be associated with lung cancer risk. The aim of this study is to assess if genetic polymorphisms in the VD pathway are associated with the prognosis of non-small cell lung cancer (NSCLC). Nine single nucleotide polymorphisms (SNPs) in five genes in the VD pathway were genotyped with the TaqMan assays in 542 patients with primary NSCLC, and the relationships between these SNPs and overall survival were evaluated. We found that SNP rs10741657 in the CYP2R1 gene was associated with the prognosis of NSCLC, especially in elderly patients and not being treated with chemotherapy. Some of the VD pathway-related genetic polymorphisms may influence the prognosis of NSCLC. More research is needed to further confirm the finding and test if VD supplements can be used for NSCLC treatment.

MTA1 expression correlates significantly with cigarette smoke in non-small cell lung cancer

2011 ◽  
Vol 459 (4) ◽  
pp. 415-422 ◽  
Author(s):  
Lei Xu ◽  
Xiao-yun Mao ◽  
Chui-feng Fan ◽  
Hua-chuan Zheng
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cigarette Smoke ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung
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