scholarly journals Wnt/CTNNB1 Signal Transduction Pathway Inhibits the Expression of ZFP36 in Squamous Cell Carcinoma, by Inducing Transcriptional Repressors SNAI1, SLUG and TWIST

2020 ◽  
Vol 21 (16) ◽  
pp. 5692
Author(s):  
Emma D. Zanfi ◽  
Sebastian Fantini ◽  
Roberta Lotti ◽  
Matteo Bertesi ◽  
Alessandra Marconi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Signal Transduction Pathway ◽  
Transcriptional Repressors ◽  
Gene Encoding ◽  
Epithelial Cancers ◽  
Normal Keratinocytes ◽  
Mrna Binding Protein ◽  
Mrna Binding

The Wnt/CTNNB1 pathway is often deregulated in epithelial tumors. The ZFP36 gene, encoding the mRNA binding protein Tristetraprolin (TTP), is downregulated in several cancers, where it has been described to behave as a tumor suppressor. By this report, we show that Wnt/CTNNB1 pathway is constitutively activated, and ZFP36 expression is downregulated in Squamous Cell Carcinoma (SCC) cell lines compared to normal keratinocytes. Moreover, we suggest that the decrease of ZFP36 expression might depend on the activity of transcriptional repressors SNAI1, SLUG and TWIST, whose expression is induced by Wnt/CTNNB1, highlighting a potential regulatory mechanism underlying ZFP36 downregulation in epithelial cancers.

Marker profiling of normal keratinocytes identifies the stroma from squamous cell carcinoma of the oral cavity as a modulatory microenvironment in co-culture

2007 ◽  
Vol 83 (11-12) ◽  
pp. 837-848 ◽  
Author(s):  
Lukas Lacina ◽  
Barbora Dvořánkova ◽  
Karel Smetana ◽  
Martin Chovanec ◽  
Jan Plzák ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Normal Keratinocytes

scholarly journals Identification of a Novel Papillomavirus Associated with Squamous Cell Carcinoma in a Domestic Cat

2019 ◽  
Author(s):  
Maura Carrai ◽  
Kate van Brussel ◽  
Mang Shi ◽  
Ci-Xiu Li ◽  
John S Munday ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Excisional Biopsy ◽  
Domestic Cat ◽  
Epithelial Cancers ◽  
Specific Pcr ◽  
Mucosal Surfaces ◽  
Recurrent Squamous Cell Carcinoma ◽  
Total Dna

Papillomaviruses infect the skin and mucosal surfaces of diverse animal hosts with consequences ranging from asymptomatic colonization to highly malignant epithelial cancers. Increasing evidence suggests a role for papillomaviruses in the most common cutaneous malignancy of domestic cats, squamous cell carcinoma (SCC). Using total DNA sequencing we identified a novel feline papillomavirus in a nasal biopsy taken from a cat presenting with both nasal cavity lymphoma and recurrent squamous cell carcinoma affecting the nasal planum. We designate this novel virus as Felis catus papillomavirus 6 (FcaPV6). The complete FcaPV6 7453 bp genome was similar to those of other feline papillomaviruses and phylogenetic analysis revealed that it was most closely related to FcaPV3, although was distinct enough to represent a new viral species within the genus Taupapillomavirus. Archived excisional biopsy of the SCC, taken 20 months prior to presentation, was intensely positive on p16 immunostaining. FcaPV6, amplified using virus-specific, but not consensus, PCR was the only papillomavirus detected in DNA extracted from the SCC. Conversely, renal lymphoma, sampled at necropsy two months after presentation, tested negative on FcaPV6-specific PCR. In sum, using metagenomics we demonstrate the presence of a novel feline papillomavirus in association with cutaneous squamous cell carcinoma.

SART1 Gene Encoding Squamous Cell Carcinoma Antigen Recognized by Cytotoxic T Lymphocytes

Cell Therapy ◽  
2000 ◽  
pp. 15-28
Author(s):  
Kyogo Itoh ◽  
Shigeki Shichijo ◽  
Yoshiko Inoue ◽  
Akihiro Hayashi ◽  
Uhi Toh ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
T Lymphocytes ◽  
Cell Carcinoma ◽  
Cytotoxic T Lymphocytes ◽  
Squamous Cell ◽  
Squamous Cell Carcinoma Antigen ◽  
Gene Encoding

scholarly journals Identification of a Novel Papillomavirus Associated with Squamous Cell Carcinoma in a Domestic Cat

Viruses ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 124
Author(s):  
Maura Carrai ◽  
Kate Van Brussel ◽  
Mang Shi ◽  
Ci-Xiu Li ◽  
Wei-Shan Chang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Excisional Biopsy ◽  
Domestic Cat ◽  
Epithelial Cancers ◽  
Specific Pcr ◽  
Mucosal Surfaces ◽  
Recurrent Squamous Cell Carcinoma ◽  
Total Dna

Papillomaviruses infect the skin and mucosal surfaces of diverse animal hosts with consequences ranging from asymptomatic colonization to highly malignant epithelial cancers. Increasing evidence suggests a role for papillomaviruses in the most common cutaneous malignancy of domestic cats, squamous cell carcinoma (SCC). Using total DNA sequencing we identified a novel feline papillomavirus in a nasal biopsy taken from a cat presenting with both nasal cavity lymphoma and recurrent squamous cell carcinoma affecting the nasal planum. We designate this novel virus as Felis catus papillomavirus 6 (FcaPV6). The complete FcaPV6 7453 bp genome was similar to those of other feline papillomaviruses and phylogenetic analysis revealed that it was most closely related to FcaPV3, although was distinct enough to represent a new viral type. Classification of FcaPV6 in a new genus alongside FcaPVs 3, 4 and 5 is supported. Archived excisional biopsy of the SCC, taken 20 months prior to presentation, was intensely positive on p16 immunostaining. FcaPV6, amplified using virus-specific, but not consensus, PCR, was the only papillomavirus detected in DNA extracted from the SCC. Conversely, renal lymphoma, sampled at necropsy two months after presentation, tested negative on FcaPV6-specific PCR. In sum, using metagenomics we demonstrate the presence of a novel feline papillomavirus in association with cutaneous squamous cell carcinoma.

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