scholarly journals Potential Role of Insulin Growth-Factor-Binding Protein 2 as Therapeutic Target for Obesity-Related Insulin Resistance

2021 ◽  
Vol 22 (3) ◽  
pp. 1133
Author(s):  
Hatim Boughanem ◽  
Elena M. Yubero-Serrano ◽  
José López-Miranda ◽  
Francisco J. Tinahones ◽  
Manuel Macias-Gonzalez
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Growth Factor ◽  
Therapeutic Target ◽  
Binding Protein ◽  
Factor Binding ◽  
Insulin Growth Factor

Evidence from observational and in vitro studies suggests that insulin growth-factor-binding protein type 2 (IGFBP2) is a promising protein in non-communicable diseases, such as obesity, insulin resistance, metabolic syndrome, or type 2 diabetes. Accordingly, great efforts have been carried out to explore the role of IGFBP2 in obesity state and insulin-related diseases, which it is typically found decreased. However, the physiological pathways have not been explored yet, and the relevance of IGFBP2 as an important pathway integrator of metabolic disorders is still unknown. Here, we review and discuss the molecular structure of IGFBP2 as the first element of regulating the expression of IGFBP2. We highlight an update of the association between low serum IGFBP2 and an increased risk of obesity, type 2 diabetes, metabolic syndrome, and low insulin sensitivity. We hypothesize mechanisms of IGFBP2 on the development of obesity and insulin resistance in an insulin-independent manner, which meant that could be evaluated as a therapeutic target. Finally, we cover the most interesting lifestyle modifications that regulate IGFBP2, since lifestyle factors (diet and/or physical activity) are associated with important variations in serum IGFBP2.

scholarly journals Isoform- and Paralog-Switching in IR-Signaling: When Diabetes Opens the Gates to Cancer

Biomolecules ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1617
Author(s):  
Pierluigi Scalia ◽  
Antonio Giordano ◽  
Caroline Martini ◽  
Stephen J. Williams
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Growth Factor ◽  
Solid Tumors ◽  
Common Finding ◽  
Absolute Increase ◽  
Preferential Expression ◽  
Exon 11

Insulin receptor (IR) and IR-related signaling defects have been shown to trigger insulin-resistance in insulin-dependent cells and ultimately to give rise to type 2 diabetes in mammalian organisms. IR expression is ubiquitous in mammalian tissues, and its over-expression is also a common finding in cancerous cells. This latter finding has been shown to associate with both a relative and absolute increase in IR isoform-A (IR-A) expression, missing 12 aa in its EC subunit corresponding to exon 11. Since IR-A is a high-affinity transducer of Insulin-like Growth Factor-II (IGF-II) signals, a growth factor is often secreted by cancer cells; such event offers a direct molecular link between IR-A/IR-B increased ratio in insulin resistance states (obesity and type 2 diabetes) and the malignant advantage provided by IGF-II to solid tumors. Nonetheless, recent findings on the biological role of isoforms for cellular signaling components suggest that the preferential expression of IR isoform-A may be part of a wider contextual isoform-expression switch in downstream regulatory factors, potentially enhancing IR-dependent oncogenic effects. The present review focuses on the role of isoform- and paralog-dependent variability in the IR and downstream cellular components playing a potential role in the modulation of the IR-A signaling related to the changes induced by insulin-resistance-linked conditions as well as to their relationship with the benign versus malignant transition in underlying solid tumors.

scholarly journals Insulin-like growth factor-binding protein-1 in the prediction and development of type 2 diabetes in middle-aged Swedish men

Diabetologia ◽  
2008 ◽  
Vol 51 (7) ◽  
pp. 1135-1145 ◽  
Author(s):  
M. S. Lewitt ◽  
A. Hilding ◽  
C.-G. Östenson ◽  
S. Efendic ◽  
K. Brismar ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Middle Aged ◽  
Factor Binding

scholarly journals Insulin-Like Growth Factor Binding Protein 2 (IGFBP-2) and the Risk of Developing Type 2 Diabetes

Diabetes ◽  
2018 ◽  
Vol 68 (1) ◽  
pp. 188-197 ◽  
Author(s):  
Clemens Wittenbecher ◽  
Meriem Ouni ◽  
Olga Kuxhaus ◽  
Markus Jähnert ◽  
Pascal Gottmann ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding

The Role of Diet in Patients with Metabolic Syndrome

2019 ◽  
Vol 26 (19) ◽  
pp. 3613-3619 ◽  
Author(s):  
Paloma Almeda-Valdes ◽  
Roberto J. Herrera-Mercadillo ◽  
Carlos A. Aguilar-Salinas ◽  
Misael Uribe ◽  
Nahum Méndez-Sánchez
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Coronary Heart Disease ◽  
Dietary Fat ◽  
Lifestyle Modification ◽  
Fat Intake ◽  
High Prevalence

Metabolic syndrome is a frequent metabolic disorder characterized by obesity and insulin resistance seems to be the main pathophysiological alteration. The goal of treating metabolic syndrome is to reduce the risk of coronary heart disease and the development of type 2 diabetes. The lifestyle modification therapy combines specific recommendations on diet alone or combined with other strategies. In this review, we address the following topics: 1) the importance of the high prevalence of metabolic syndrome and obesity, and 2) the role of lifestyle modification focusing on dietary fat intake in the management of MS.

scholarly journals Increased DNA methylation levels of the insulin-like growth factor binding protein 1 gene are associated with type 2 diabetes in Swedish men

2013 ◽  
Vol 5 (1) ◽  
Author(s):  
Tianwei Gu ◽  
Harvest F Gu ◽  
Agneta Hilding ◽  
Louise K Sjöholm ◽  
Claes-Göran Östenson ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dna Methylation ◽  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding

scholarly journals Insulin-like growth factor binding protein 2 (IGFBP-2) and the risk of developing type 2 diabetes

2019 ◽  
Author(s):  
M Ouni ◽  
C Wittenbecher ◽  
O Kuxhaus ◽  
M Jaehnert ◽  
M Schulze ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding
Sign in / Sign up

Export Citation Format

Share Document