Myositis/Myasthenia after Pembrolizumab in a Bladder Cancer Patient with an Autoimmunity-Associated HLA: Immune–Biological Evaluation and Case Report

Pembrolizumab (mAb to PD-1) has been recently approved for the therapy of pretreated urothelial cancer. Despite the efficacy, it is often accompanied by unpredictable and sometime severe immune-related (ir) adverse events (AEs). Here, we report the clinical and immune–biological characterization of a patient with a metastatic bladder cancer who developed myositis signs (M) and a myasthenia-like syndrome (MLS) during treatment with pembrolizumab. The patient presented an autoimmunity-associated HLA haplotype (HLA-A*02/HLA-B*08/HLA-C*07/HLA-DRB1*03) and experienced an increase in activated CD8 T-cells along the treatment. The symptomatology regressed after pembrolizumab discontinuation and a pyridostigmine and steroids-based therapy. This is the first report of concurrent M and MLS appearance in cancer patients receiving pembrolizumab. More efforts are needed to define early the risk and the clinical meaning of irAEs in this setting.

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Characterization of HLA-A*0201 restricted cytotoxic CD8+ T cells directed against ewing tumor specific antigens

Klinische Pädiatrie ◽

10.1055/s-0029-1222667 ◽

2009 ◽

Vol 221 (03) ◽

Author(s):

S Pirson ◽

U Thiel ◽

H Bernhard ◽

GHS Richter ◽

S Burdach

Keyword(s):

T Cells ◽

Cd8 T Cells ◽

Specific Antigens ◽

Ewing Tumor

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Characterization of myelin oligodendrocyte glycoprotein (MOG)35–55-specific CD8+ T cells in experimental autoimmune encephalomyelitis

Chinese Medical Journal ◽

10.1097/cm9.0000000000000551 ◽

2019 ◽

Vol 132 (24) ◽

pp. 2934-2940

Author(s):

Yong Peng ◽

Fei-Zhou Zhu ◽

Zhi-Xing Chen ◽

Jian-Xiong Zhou ◽

Lu Gan ◽

...

Keyword(s):

T Cells ◽

Experimental Autoimmune Encephalomyelitis ◽

Cd8 T Cells ◽

Myelin Oligodendrocyte Glycoprotein ◽

Autoimmune Encephalomyelitis ◽

Experimental Autoimmune

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Characterization of Melan-A reactive memory CD8+ T cells in a healthy donor

International Immunology ◽

10.1093/intimm/dxn066 ◽

2008 ◽

Vol 20 (8) ◽

pp. 1087-1096 ◽

Cited By ~ 12

Author(s):

V. Voelter ◽

N. Rufer ◽

S. Reynard ◽

G. Greub ◽

R. Brookes ◽

...

Keyword(s):

T Cells ◽

Cd8 T Cells ◽

Healthy Donor ◽

Memory Cd8 T Cells

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Ex Vivo Characterization of Multiepitopic Tumor-Specific CD8 T Cells in Patients with Chronic Myeloid Leukemia: Implications for Vaccine Development and Adoptive Cellular Immunotherapy

The Journal of Immunology ◽

10.4049/jimmunol.174.12.8210 ◽

2005 ◽

Vol 174 (12) ◽

pp. 8210-8218 ◽

Cited By ~ 81

Author(s):

Monique Gannagé ◽

Michal Abel ◽

Anne-Sophie Michallet ◽

Stéphanie Delluc ◽

Marion Lambert ◽

...

Keyword(s):

T Cells ◽

Chronic Myeloid Leukemia ◽

Cd8 T Cells ◽

Myeloid Leukemia ◽

Vaccine Development ◽

Ex Vivo ◽

Cellular Immunotherapy ◽

Adoptive Cellular Immunotherapy

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Preparation and Biological Evaluation of Si-Substituted HA Ceramics with Controlled Composition

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.361-363.1059 ◽

2007 ◽

Vol 361-363 ◽

pp. 1059-1062

Author(s):

Mickael Palard ◽

J. Combes ◽

Eric Champion ◽

Didier Bernache-Assollant

Keyword(s):

Thermal Treatment ◽

Biological Evaluation ◽

Precipitation Process ◽

Biological Characterization ◽

Hydroxyapatite Ceramics

This work aimed at preparing dense and monophasic silicated hydroxyapatite ceramics over the range 0 ≤ x ≤ 1.0 mol of silicon. The synthesis of the powder via an aqueous precipitation process followed by an adapted thermal treatment showed that it was possible to obtain dense single-phased apatite ceramics containing up to 0.6 mol of silicon. The in vitro biological characterization of these materials was performed.

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