Organic Anion Transporting Polypeptide 1B1 Is a Potential Reporter for Dual MR and Optical Imaging

Membrane proteins responsible for transporting magnetic resonance (MR) and fluorescent contrast agents are of particular importance because they are potential reporter proteins in noninvasive molecular imaging. Gadobenate dimeglumine (Gd-BOPTA), a liver-specific MR contrast agent, has been used globally for more than 10 years. However, the corresponding molecular transportation mechanism has not been validated. We previously reported that the organic anion transporting polypeptide (OATP) 1B3 has an uptake capability for both MR agents (Gd-EOB-DTPA) and indocyanine green (ICG), a clinically available near-infrared (NIR) fluorescent dye. This study further evaluated OATP1B1, another polypeptide of the OATP family, to determine its reporter capability. In the OATP1B1 transfected 293T transient expression model, both Gd-BOPTA and Gd-EOB-DTPA uptake were confirmed through 1.5 T MR imaging. In the constant OAPT1B1 and OATP1B3 expression model in the HT-1080 cell line, both HT-1080-OAPT1B1 and HT-1080-OATP1B3 were observed to ingest Gd-BOPTA and Gd-EOB-DTPA. Lastly, we validated the ICG uptake capability of both OATP1B1 and OATP1B3. OAPT1B3 exhibited a superior ICG uptake capability to that of OAPT1B1. We conclude that OATP1B1 is a potential reporter for dual MR and NIR fluorescent molecular imaging, especially in conjunction with Gd-BOPTA.

Download Full-text

Coordination polymer hybridized Au nanocages: a nanoplatform for dual-modality imaging guided near-infrared driven photothermal therapy in vivo

Journal of Materials Chemistry B ◽

10.1039/c7tb02302b ◽

2017 ◽

Vol 5 (44) ◽

pp. 8761-8769 ◽

Cited By ~ 5

Author(s):

Congyang Yan ◽

Lili Cui ◽

Qi Yang ◽

Xiaobao Zhou ◽

Lixing Pan ◽

...

Keyword(s):

Magnetic Resonance ◽

Coordination Polymer ◽

Mr Imaging ◽

Photothermal Therapy ◽

Near Infrared ◽

Dual Modality ◽

Dual Modality Imaging

Coordination polymer hybridized Au nanocages (AuNC@CPs) were prepared, which were used for near-infrared (NIR)-driven photothermal therapy (PTT) guided by photoacoustic (PA) and magnetic resonance (MR) imaging in vivo.

Download Full-text

Gadolinium-Doped Silica Nanoparticles Encapsulating Indocyanine Green for Near Infrared and Magnetic Resonance Imaging

Small ◽

10.1002/smll.201200258 ◽

2012 ◽

Vol 8 (18) ◽

pp. 2856-2868 ◽

Cited By ~ 45

Author(s):

Parvesh Sharma ◽

Niclas E. Bengtsson ◽

Glenn A. Walter ◽

Han-Byul Sohn ◽

Guangyin Zhou ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Indocyanine Green ◽

Silica Nanoparticles ◽

Near Infrared ◽

Resonance Imaging

Download Full-text

Abstract 718: Optical molecular imaging of HER1-positive cancer using near-infrared PEGylated indocyanine green-labeled panitumumab.

10.1158/1538-7445.am2013-718 ◽

2013 ◽

Author(s):

Yang Zhou ◽

Young-Seung Kim ◽

Diane E. Milenic ◽

Kwamena E. Baidoo ◽

Martin W. Brechbiel

Keyword(s):

Molecular Imaging ◽

Indocyanine Green ◽

Near Infrared ◽

Optical Molecular Imaging

Download Full-text

Evaluation of intraaxial enhancing brain tumors on magnetic resonance imaging: intraindividual crossover comparison of gadobenate dimeglumine and gadopentetate dimeglumine for visualization and assessment, and implications for surgical intervention

Journal of Neurosurgery ◽

10.3171/jns.2007.106.4.557 ◽

2007 ◽

Vol 106 (4) ◽

pp. 557-566 ◽

Cited By ~ 33

Author(s):

Matthew J. Kuhn ◽

Piero Picozzi ◽

Joseph A. Maldjian ◽

Ilona M. Schmalfuss ◽

Kenneth R. Maravilla ◽

...

Keyword(s):

Magnetic Resonance ◽

Brain Tumors ◽

Mr Imaging ◽

Contrast Agent ◽

Contrast Enhancement ◽

Spin Echo ◽

Gadopentetate Dimeglumine ◽

Gadobenate Dimeglumine ◽

Kappa Statistics ◽

End Points

Object The goal in this article was to compare 0.1 mmol/kg doses of gadobenate dimeglumine (Gd-BOPTA) and gadopentetate dimeglumine, also known as gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA), for enhanced magnetic resonance (MR) imaging of intraaxial brain tumors. Methods Eighty-four patients with either intraaxial glioma (47 patients) or metastasis (37 patients) underwent two MR imaging examinations at 1.5 tesla, one with Gd-BOPTA as the contrast agent and the other with Gd-DTPA. The interval between fully randomized contrast medium administrations was 2 to 7 days. The T1-weighted spin echo and T2-weighted fast spin echo images were acquired before administration of contrast agents and T1-weighted spin echo images were obtained after the agents were administered. Acquisition parameters and postinjection acquisition times were identical for the two examinations in each patient. Three experienced readers working in a fully blinded fashion independently evaluated all images for degree and quality of available information (lesion contrast enhancement, lesion border delineation, definition of disease extent, visualization of the lesion's internal structures, global diagnostic preference) and quantitative enhancement (that is, the extent of lesion enhancement after contrast agent administration compared with that seen before its administration [hereafter referred to as percent enhancement], lesion/brain ratio, and contrast/noise ratio). Differences were tested with the Wilcoxon signed-rank test. Reader agreement was assessed using kappa statistics. Significantly better diagnostic information/imaging performance (p < 0.0001, all readers) was obtained with Gd-BOPTA for all visualization end points. Global preference for images obtained with Gd-BOPTA was expressed for 42 (50%), 52 (61.9%), and 56 (66.7%) of 84 patients (readers 1, 2, and 3, respectively) compared with images obtained with Gd-DTPA contrast in four (4.8%), six (7.1%), and three (3.6%) of 84 patients. Similar differences were noted for all other visualization end points. Significantly greater quantitative contrast enhancement (p < 0.04) was noted after administration of Gd-BOPTA. Reader agreement was good (κ > 0.4). Conclusions Lesion visualization, delineation, definition, and contrast enhancement are significantly better after administration of 0.1 mmol/kg Gd-BOPTA, potentially allowing better surgical planning and follow up and improved disease management.

Download Full-text

The influence of Gd-DOTA ratios conjugating PLGA-PEG micelles encapsulated IR-1061 in bimodal over–1000 nm near–infrared fluorescence and magnetic resonance imaging

Biomaterials Science ◽

10.1039/d1bm01574e ◽

2022 ◽

Author(s):

Doan Thi Kim Dung ◽

Masakazu Umezawa ◽

Kazunobu Ohnuki ◽

Karina Nigoghossian ◽

Kyohei Okubo ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Mr Imaging ◽

Fluorescence Imaging ◽

Multimodal Imaging ◽

Near Infrared ◽

Resonance Imaging ◽

Biological Objects ◽

Nir Fluorescence ◽

Multidimensional Information

Multimodal imaging can provide multidimensional information for understanding concealed microstructures or bioprocesses in biological objects. The combination of over–1000 nm near–infrared (OTN–NIR) fluorescence imaging and magnetic resonance (MR) imaging is...

Download Full-text

PET/MR Imaging Consensus Paper: A Joint Paper by the Society of Nuclear Medicine and Molecular Imaging Technologist Section and the Section for Magnetic Resonance Technologists

Journal of Nuclear Medicine Technology ◽

10.2967/jnmt.113.123869 ◽

2013 ◽

Vol 41 (2) ◽

pp. 108-113 ◽

Cited By ~ 6

Author(s):

C. D. Gilmore ◽

C. R. Comeau ◽

A. M. Alessi ◽

M. Blaine ◽

G. N. El Fakhri ◽

...

Keyword(s):

Nuclear Medicine ◽

Molecular Imaging ◽

Magnetic Resonance ◽

Mr Imaging ◽

Joint Paper ◽

Consensus Paper

Download Full-text

Developmental Venous Anomaly of Petrous Veins: Intraoperative Findings and Indocyanine Green Video Angiographic Study

Operative Neurosurgery ◽

10.1227/01.neu.0000326029.47090.16 ◽

2008 ◽

Vol 62 (suppl_5) ◽

pp. ONS418-ONS422 ◽

Cited By ~ 3

Author(s):

Paolo Ferroli ◽

Giovanni Tringali ◽

Erminia Albanese ◽

Giovanni Broggi

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Indocyanine Green ◽

Trigeminal Nerve ◽

Near Infrared ◽

Developmental Venous Anomaly ◽

Venous Angioma ◽

Venous Anomaly ◽

Resonance Imaging ◽

Angiographic Study

Abstract Objective: We describe the intraoperative findings and results of an indocyanine green (ICG) video angiographic study in a patient with a developmental venous anomaly of the petrous veins. Clinical Presentation: A 56-year-old man sought treatment after experiencing lacerating facial pain on the right side for almost 2 years. His neurological examination results were normal. A magnetic resonance imaging scan revealed the presence of a venous angioma in close relationship with the trigeminal nerve and the intrapontine tract of its fibers. The patient underwent a retrosigmoid craniotomy to explore the cerebellopontine angle. Near-infrared ICG video angiography was used to study the venous pattern of circulation. The venous angioma did not appear to be the source of any compression and was left untouched. At the entry zone of the nerve root, the trigeminal nerve was found to be compressed by a loop of the superior cerebellar artery, which was moved and repositioned away from the nerve. Results: Near-infrared ICG video angiography disclosed an unexpected difference in filling time between developmental venous anomaly drainage veins and normal veins. The patient's pain resolved after microvascular decompression. Conclusion: Near-infrared ICG video angiography was particularly accurate and useful in the study of the venous dynamic of circulation. Further studies are required to confirm the supposed capability of ICG video angiography to differentiate developmental venous anomaly drainage veins and normal veins. Although magnetic resonance imaging supported the involvement of the venous angioma in the etiopathogenesis of this patient's trigeminal pain, surgical exploration disclosed a different cause.

Download Full-text

In vivo Molecular Imaging of Cancer with a Quenching Near-Infrared Fluorescent Probe Using Conjugates of Monoclonal Antibodies and Indocyanine Green

Cancer Research ◽

10.1158/0008-5472.can-08-3116 ◽

2009 ◽

Vol 69 (4) ◽

pp. 1268-1272 ◽

Cited By ~ 209

Author(s):

Mikako Ogawa ◽

Nobuyuki Kosaka ◽

Peter L. Choyke ◽

Hisataka Kobayashi

Keyword(s):

Monoclonal Antibodies ◽

Molecular Imaging ◽

Indocyanine Green ◽

Fluorescent Probe ◽

Near Infrared

Download Full-text

Mass Spectrometry Imaging of atherosclerosis-affine Gadofluorine following Magnetic Resonance Imaging

Scientific Reports ◽

10.1038/s41598-019-57075-6 ◽

2020 ◽

Vol 10 (1) ◽

Cited By ~ 2

Author(s):

Fabian Lohöfer ◽

Rebecca Buchholz ◽

Almut Glinzer ◽

Katharina Huber ◽

Helena Haas ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Mass Spectrometry ◽

Molecular Imaging ◽

Magnetic Resonance ◽

Mr Imaging ◽

Mass Spectrometry Imaging ◽

Ex Vivo ◽

Specific Information ◽

Specific Substrate ◽

Resonance Imaging

AbstractMolecular imaging of atherosclerosis by Magnetic Resonance Imaging (MRI) has been impaired by a lack of validation of the specific substrate responsible for the molecular imaging signal. We therefore aimed to investigate the additive value of mass spectrometry imaging (MSI) of atherosclerosis-affine Gadofluorine P for molecular MRI of atherosclerotic plaques. Atherosclerotic Ldlr−/− mice were investigated by high-field MRI (7 T) at different time points following injection of atherosclerosis-affine Gadofluorine P as well as at different stages of atherosclerosis formation (4, 8, 16 and 20 weeks of HFD). At each imaging time point mice were immediately sacrificed after imaging and aortas were excised for mass spectrometry imaging: Matrix Assisted Laser Desorption Ionization (MALDI) Imaging and Laser Ablation – Inductively Coupled Plasma – Mass Spectrometry (LA-ICP-MS) imaging. Mass spectrometry imaging allowed to visualize the localization and measure the concentration of the MR imaging probe Gadofluorine P in plaque tissue ex vivo with high spatial resolution and thus adds novel and more target specific information to molecular MR imaging of atherosclerosis.

Download Full-text