scholarly journals Synchrotron-Based Fourier-Transform Infrared Micro-SPECTROSCOPY (SR-FTIRM) Fingerprint of the Small Anionic Molecule Cobaltabis(dicarbollide) Uptake in Glioma Stem Cells

2021 ◽  
Vol 22 (18) ◽  
pp. 9937
Author(s):  
Miquel Nuez-Martínez ◽  
Leire Pedrosa ◽  
Immaculada Martinez-Rovira ◽  
Ibraheem Yousef ◽  
Diouldé Diao ◽  
...  
Keyword(s):  
Fourier Transform ◽  
Fourier Transform Infrared ◽  
Infrared Range ◽  
Killing Effect ◽  
Cycle Arrest ◽  
Boron Neutron Capture ◽  
Glioma Initiating Cells ◽  
Anti Cancer ◽  
Entire Cell ◽  
Synchrotron Light

The anionic cobaltabis (dicarbollide) [3,3′-Co(1,2-C2B9H11)2]−, [o-COSAN]−, is the most studied icosahedral metallacarborane. The sodium salts of [o-COSAN]− could be an ideal candidate for the anti-cancer treatment Boron Neutron Capture Therapy (BNCT) as it possesses the ability to readily cross biological membranes thereby producing cell cycle arrest in cancer cells. BNCT is a cancer therapy based on the potential of 10B atoms to produce α particles that cross tissues in which the 10B is accumulated without damaging the surrounding healthy tissues, after being irradiated with low energy thermal neutrons. Since Na[o-COSAN] displays a strong and characteristic ν(B-H) frequency in the infrared range 2.600–2.500 cm−1, we studied the uptake of Na[o-COSAN] followed by its interaction with biomolecules and its cellular biodistribution in two different glioma initiating cells (GICs), mesenchymal and proneural respectively, by using Synchrotron Radiation-Fourier Transform Infrared (FTIR) micro-spectroscopy (SR-FTIRM) facilities at the MIRAS Beamline of ALBA synchrotron light source. The spectroscopic data analysis from the bands in the regions of DNA, proteins, and lipids permitted to suggest that after its cellular uptake, Na[o-COSAN] strongly interacts with DNA strings, modifies proteins secondary structure and also leads to lipid saturation. The mapping suggests the nuclear localization of [o-COSAN]−, which according to reported Monte Carlo simulations may result in a more efficient cell-killing effect compared to that in a uniform distribution within the entire cell. In conclusion, we show pieces of evidence that at low doses, [o-COSAN]− translocates GIC cells’ membranes and it alters the physiology of the cells, suggesting that Na[o-COSAN] is a promising agent to BNCT for glioblastoma cells.

scholarly journals Vibrational biospectroscopic study and chemical structure analysis of unsaturated polyamides nanoparticles as anti–cancer polymeric nanomedicines using synchrotron radiation

2018 ◽  
Vol 6 (2) ◽  
pp. 167 ◽  
Author(s):  
Alireza Heidari
Keyword(s):  
Fourier Transform ◽  
Synchrotron Radiation ◽  
Ftir Spectroscopy ◽  
Chemical Structure ◽  
Fourier Transform Infrared ◽  
Considerable Change ◽  
Total Reflection ◽  
Attenuated Total Reflection ◽  
Anti Cancer ◽  
Before And After

Firstly, unsaturated polyamides nanoparticles were hardened by continuous synchrotron radiation and then, the induced changes in its chemical structure were studied by Attenuated Total Reflection–Fourier Transform Infrared (ATR–FTIR) spectroscopy. It was shown that applying synchrotron radiation for hardening not only leads to reduction of hardening time but also creates cross link in polymer by breaking Carbon–Carbon double bond, without any considerable change in its chemical structure. In addition, an unsaturated polyamide nanoparticle as anti–cancer polymeric nanomedicines is hardened by synchrotron radiation. Its chemical structure before and after hardening is studied using Raman and Attenuated Total Reflection–Fourier Transform Infrared (ATR–FTIR) spectroscopy. The results show that Raman spectroscopy is considerably better than Attenuated Total Reflection–Fourier Transform Infrared (ATR–FTIR) spectroscopy in detecting the changes happened in chemical structure.  

Fourier transform infrared spectroscopy (FTIR) characterization of the interaction of anti-cancer photosensitizers with dendrimers

2015 ◽  
Vol 408 (2) ◽  
pp. 535-544 ◽  
Author(s):  
Monika Dabrzalska ◽  
Nuria Benseny-Cases ◽  
Ramon Barnadas-Rodríguez ◽  
Serge Mignani ◽  
Maria Zablocka ◽  
...  
Keyword(s):  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Fourier Transform Infrared Spectroscopy ◽  
Fourier Transform Infrared ◽  
Ftir Characterization ◽  
Anti Cancer

scholarly journals Low temperature mid-infrared cross-sections for peroxyacetyl nitrate (PAN) vapour

2005 ◽  
Vol 5 (4) ◽  
pp. 5669-5685
Author(s):  
G. Allen ◽  
J. J. Remedios ◽  
K. M. Smith
Keyword(s):  
Fourier Transform ◽  
Low Temperature ◽  
Absorption Spectra ◽  
Cross Sections ◽  
Spectral Resolution ◽  
Fourier Transform Infrared ◽  
Infrared Range ◽  
Peroxyacetyl Nitrate ◽  
Mid Infrared ◽  
Infrared Spectrometer

Abstract. Laboratory absorption spectra of peroxyacetyl nitrate (PAN, CH3C(O)OONO2) vapour have been measured in the mid-infrared range 550 cm−1 to 1400 cm−1 (18.2 to 7.14 µm) at both 250 K and 273 K, using a Fourier transform infrared spectrometer at a nominal spectral resolution of 0.25 cm−1 (unapodised). In addition, the 1600 cm

Macroscopic Fourier transform infrared scanning in reflection mode (MA-rFTIR), a new tool for chemical imaging of cultural heritage artefacts in the mid-infrared range

The Analyst ◽  
2014 ◽  
Vol 139 (10) ◽  
pp. 2489-2498 ◽  
Author(s):  
Stijn Legrand ◽  
Matthias Alfeld ◽  
Frederik Vanmeert ◽  
Wout De Nolf ◽  
Koen Janssens
Keyword(s):  
Fourier Transform ◽  
Cultural Heritage ◽  
Fourier Transform Infrared ◽  
Chemical Imaging ◽  
Infrared Range ◽  
Reflection Mode ◽  
Mid Infrared ◽  
Infrared Scanning

Macroscopic Fourier transform infrared scanning in reflection mode (MA-rFTIR), a new tool for the chemical imaging of cultural heritage artefacts in the extended mid-infrared range (7500–375 cm−1).

FR-IR Molecular Microanalysis System

1990 ◽  
Vol 48 (2) ◽  
pp. 270-271
Author(s):  
John A. Reffner ◽  
William T. Wihlborg
Keyword(s):  
Fourier Transform ◽  
Fourier Transform Infrared ◽  
Integrated System ◽  
Morphological Examination ◽  
Fully Integrated ◽  
Ir Microscopy ◽  
Normal Functions ◽  
Infrared Microspectroscopy ◽  
Infrared Spectral ◽  
Ft Ir

The IRμs™ is the first fully integrated system for Fourier transform infrared (FT-IR) microscopy. FT-IR microscopy combines light microscopy for morphological examination with infrared spectroscopy for chemical identification of microscopic samples or domains. Because the IRμs system is a new tool for molecular microanalysis, its optical, mechanical and system design are described to illustrate the state of development of molecular microanalysis. Applications of infrared microspectroscopy are reviewed by Messerschmidt and Harthcock.Infrared spectral analysis of microscopic samples is not a new idea, it dates back to 1949, with the first commercial instrument being offered by Perkin-Elmer Co. Inc. in 1953. These early efforts showed promise but failed the test of practically. It was not until the advances in computer science were applied did infrared microspectroscopy emerge as a useful technique. Microscopes designed as accessories for Fourier transform infrared spectrometers have been commercially available since 1983. These accessory microscopes provide the best means for analytical spectroscopists to analyze microscopic samples, while not interfering with the FT-IR spectrometer’s normal functions.

Fourier transform infrared spectrum of 13C32S2 in the 3v3 band region

1996 ◽  
Vol 89 (4) ◽  
pp. 1145-1155
Author(s):  
JACQUES WALRAND ◽  
GHISLAIN BLANQUET ◽  
JEAN-FRANCOIS BLAVIER ◽  
HARALD BREDOHL ◽  
IWAN DUBOIS
Keyword(s):  
Fourier Transform ◽  
Infrared Spectrum ◽  
Fourier Transform Infrared ◽  
Band Region

ANALYSIS OF AUTOMATIC TRANSMISSION USING FOURIER TRANSFORM INFRARED (FTIR) SPECTROCOPY

2019 ◽  
Vol 7 (SI-TeMIC18) ◽  
Author(s):  
Norhanifah Abdul Rahman ◽  
Matzaini Katon Katon ◽  
Nurina Alya Zulkifli Zulkifli
Keyword(s):  
Fourier Transform ◽  
Automatic Transmission ◽  
Fourier Transform Infrared ◽  
Oil Analysis ◽  
Wear Particles ◽  
Reliable Technique ◽  
Fluid Analysis ◽  
Analysis Technique ◽  
Machine Elements ◽  
Transmission Fluid

Automatic Transmission (AT) system is efficient in the aspects of vehicle safety, comfort, reliability and driving performance. The objectives of this paper are to collect the oil samples from AT systems of engine bus according to manufacturer's recommendations and analyse collected oil samples using oil analysis technique. The sample transmission fluid which was taken from the AT gearbox has been experimentally analyzed. The oil samples were taken with an interval of 5,000km, 30,000km, 50,000km, 80,000km, 180,000km and 300,000km for AT bus operation. These samples then have been analyzed by comparing between new and used transmission fluid using Fourier Transform Infrared (FTIR) spectroscopy. Oil analysis by FTIR is a form of Predictive Maintenance (PdM) to avoid major failure in machine elements. Most machine elements are not easily accessible in the transmission system. Having a reliable technique would avoid the needs to open the components unnecessarily, hence, help to prevent catastrophic failure which are very costly, and ease of regular monitoring. In order to identify the major failures of automatic gearbox, forecasts can be made regarding the lube transmission fluid analysis test. By using this test, the minor problems can be determined before they become major failures. At the end of this research, the wear particles profile for interval mileage of AT system was obtained. Keywords: Wear, Automatic Transmission (AT), Transmission fluid, Fourier Transform Infrared (FTIR), Oil analysis.

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