scholarly journals Growth Hormone and the Human Hair Follicle

2021 ◽  
Vol 22 (24) ◽  
pp. 13205
Author(s):  
Elijah J. Horesh ◽  
Jérémy Chéret ◽  
Ralf Paus

Ever since the discoveries that human hair follicles (HFs) display the functional peripheral equivalent of the hypothalamic-pituitary-adrenal axis, exhibit elements of the hypothalamic-pituitary-thyroid axis, and even generate melatonin and prolactin, human hair research has proven to be a treasure chest for the exploration of neurohormone functions. However, growth hormone (GH), one of the dominant neurohormones of human neuroendocrine physiology, remains to be fully explored in this context. This is interesting since it has long been appreciated clinically that excessive GH serum levels induce distinct human skin pathology. Acromegaly, or GH excess, is associated with hypertrichosis, excessive androgen-independent growth of body hair, and hirsutism in females, while dysfunctional GH receptor-mediated signaling (Laron syndrome) is associated with alopecia and prominent HF defects. The outer root sheath keratinocytes have recently been shown to express functional GH receptors. Furthermore, and contrary to its name, recombinant human GH is known to inhibit female human scalp HFs’ growth ex vivo, likely via stimulating the expression of the catagen-inducing growth factor, TGF-β2. These limited available data encourage one to systematically explore the largely uncharted role of GH in human HF biology to uncover nonclassical functions of this core neurohormone in human skin physiology.

2018 ◽  
Vol 79 (3) ◽  
pp. 558-559 ◽  
Author(s):  
Irene Hernandez ◽  
Majid Alam ◽  
Christopher Platt ◽  
Jonathan Hardman ◽  
Eleanor Smart ◽  
...  
Keyword(s):  
Ex Vivo ◽  

BIO-PROTOCOL ◽  
2020 ◽  
Vol 10 (11) ◽  
Author(s):  
Atsuhiro Nishida ◽  
Yoshiki Miyawaki ◽  
Koichi Node ◽  
Makoto Akashi

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Mira Choi ◽  
Soon-Jin Choi ◽  
Sunhyae Jang ◽  
Hye-In Choi ◽  
Bo-Mi Kang ◽  
...  

AbstractShikimic acid (SA) has recently been found to be a major component of plant stem cells. The exact effects of SA on human hair follicles (HFs) is unknown. The purpose of this study was to examine the effects of SA on hair growth. We investigated the effect of SA on an in vivo C57BL/6 mouse model. We examined the expression of mannose receptor (MR), which is a known receptor of SA, in human HFs and the effect of SA on human dermal papilla cells (hDPCs), outer root sheath cells (hORSCs), and on ex vivo human hair organ culture. SA significantly prolonged anagen hair growth in the in vivo mouse model. We confirmed expression of the MR in human HFs, and that SA increased the proliferation of hDPCs and hORSCs. It was found that SA enhanced hair shaft elongation in an ex vivo human hair organ culture. SA treatment of hDPCs led to increased c-myc, hepatocyte growth factor, keratinocyte growth factor and vascular endothelial growth factor levels and upregulation of p38 MAPK and cAMP response element-binding protein levels. Our results show that SA promotes hair growth and may serve as a new therapeutic agent in the treatment of alopecia.


2019 ◽  
Vol 9 (1) ◽  
Author(s):  
María I. Calvo-Sánchez ◽  
Sandra Fernández-Martos ◽  
Juan José Montoya ◽  
Jesús Espada

An amendment to this paper has been published and can be accessed via a link at the top of the paper.


2014 ◽  
Vol 134 (1) ◽  
pp. 33-42 ◽  
Author(s):  
Silvia Vidali ◽  
Jana Knuever ◽  
Johannes Lerchner ◽  
Melanie Giesen ◽  
Tamás Bíró ◽  
...  

2019 ◽  
Vol 139 (7) ◽  
pp. 1593-1596 ◽  
Author(s):  
Majid Alam ◽  
Diana A. Below ◽  
Jérémy Chéret ◽  
Ewan A. Langan ◽  
Marta Bertolini ◽  
...  

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