scholarly journals Erythroid Differentiation Regulator 1 Strengthens TCR Signaling by Enhancing PLCγ1 Signal Transduction Pathway

2022 ◽  
Vol 23 (2) ◽  
pp. 844
Author(s):  
Myun Soo Kim ◽  
Dongmin Park ◽  
Sora Lee ◽  
Sunyoung Park ◽  
Kyung Eun Kim ◽  
...  
Keyword(s):  
Signal Transduction ◽  
T Cells ◽  
Cd4 T Cells ◽  
Signal Transduction Pathway ◽  
Erythroid Differentiation ◽  
Transduction Pathway ◽  
Tcr Signaling ◽  
Peripheral T Cells ◽  
Signal Regulation

Erythroid differentiation regulator 1 (Erdr1) has previously been reported to control thymocyte selection via TCR signal regulation, but the effect of Erdr1 as a TCR signaling modulator was not studied in peripheral T cells. In this report, it was determined whether Erdr1 affected TCR signaling strength in CD4 T cells. Results revealed that Erdr1 significantly enhanced the anti-TCR antibody-mediated activation and proliferation of T cells while failing to activate T cells in the absence of TCR stimulation. In addition, Erdr1 amplified Ca2+ influx and the phosphorylation of PLCγ1 in CD4 T cells with the TCR stimuli. Furthermore, NFAT1 translocation into nuclei in CD4 T cells was also significantly promoted by Erdr1 in the presence of TCR stimulation. Taken together, our results indicate that Erdr1 positively modulates TCR signaling strength via enhancing the PLCγ1/Ca2+/NFAT1 signal transduction pathway.

Construction of protocell-based artificial signal transduction pathway

2021 ◽  
Author(s):  
CHONG CHEN ◽  
Xuejing Wang ◽  
Ying Wang ◽  
Liangfei Tian ◽  
Jinxuan Cao
Keyword(s):  
Signal Transduction ◽  
Signal Transduction Pathway ◽  
Signal Transduction Pathways ◽  
Biological Cells ◽  
Transduction Pathway ◽  
Signal Regulation

The maintenance of an orderly and controllable multicellular society depends on the communication and signal regulation among various types of biological cells. How to replicate complicate signal transduction pathways in...

REGULATION OF IL-17, IFN-γ AND IL-10 IN HUMAN CD8+T CELLS BY CYCLIC AMP-DEPENDENT SIGNAL TRANSDUCTION PATHWAY

Cytokine ◽  
1998 ◽  
Vol 10 (11) ◽  
pp. 841-850 ◽  
Author(s):  
Hyun Chul K. Shin ◽  
Naima Benbernou ◽  
Hakim Fekkar ◽  
Stephane Esnault ◽  
Moncef Guenounou
Keyword(s):  
Signal Transduction ◽  
T Cells ◽  
Cyclic Amp ◽  
Cd8 T Cells ◽  
Signal Transduction Pathway ◽  
Transduction Pathway ◽  
Dependent Signal ◽  
Ifn Γ

scholarly journals Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes.

1995 ◽  
Vol 182 (4) ◽  
pp. 1057-1065 ◽  
Author(s):  
E W Gelfand ◽  
K Weinberg ◽  
B D Mazer ◽  
T A Kadlecek ◽  
A Weiss
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Severe Combined Immunodeficiency ◽  
Thymic Selection ◽  
Tcr Signaling ◽  
Peripheral T Cells ◽  
Tcr Signal Transduction ◽  
Immunodeficiency Syndrome ◽  
Severe Combined Immunodeficiency Syndrome ◽  
Selection Of

Recently, a severe combined immunodeficiency syndrome with a deficiency of CD8+ peripheral T cells and a TCR signal transduction defect in peripheral CD4+ T cells was associated with mutations in ZAP-70. Since TCR signaling is required in developmental decisions resulting in mature CD4 (and CD8) T cells, the presence of peripheral CD4+ T cells expressing TCRs incapable of signaling in these patients is paradoxical. Here, we show that the TCRs on thymocytes, but not peripheral T cells, from a ZAP-70-deficient patient are capable of signaling. Moreover, the TCR on a thymocyte line derived from this patient can signal, and the homologous kinase Syk is present at high levels and is tyrosine phosphorylated after TCR stimulation. Thus, Syk may compensate for the loss of ZAP-70 and account for the thymic selection of at least a subset of T cells (CD4+) in ZAP-70-deficient patients.

scholarly journals CD28 and T cell antigen receptor signal transduction coordinately regulate interleukin 2 gene expression in response to superantigen stimulation.

1992 ◽  
Vol 175 (4) ◽  
pp. 1131-1134 ◽  
Author(s):  
J D Fraser ◽  
M E Newton ◽  
A Weiss
Keyword(s):  
Gene Expression ◽  
Signal Transduction ◽  
T Cells ◽  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Interleukin 2 ◽  
Signal Transduction Pathway ◽  
Transduction Pathway ◽  
Cell Antigen

Activation of an immune response requires intercellular contact between T lymphocytes and antigen-presenting cells (APC). Interaction of the T cell antigen receptor (TCR) with antigen in the context of major histocompatibility molecules mediates signal transduction, but T cell activation appears to require the induction of a second costimulatory signal transduction pathway. Recent studies suggest that interaction of CD28 with B7 on APC might deliver such a costimulatory signal. To investigate the role of CD28 signal transduction during APC-dependent T cell activation, we have used Staphylococcal enterotoxins (SEs) presented by a B7-positive APC. We used anti-B7 monoclonal antibodies and a mutant interleukin 2 (IL-2) promoter construct, unresponsive to CD28-generated signals, in transient transfection assays to examine the contribution of the CD28-B7 interaction to IL-2 gene activation. These studies indicate that the CD28-regulated signal transduction pathway is activated during SE stimulation of T cells and plays an important role in SE induction of IL-2 gene expression through its influence upon the CD28-responsive element contained within the IL-2 gene promoter. This effect is particularly profound in the activation of the IL-2 gene in peripheral blood T cells.

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