Long-Term Effectiveness and Safety of Tafluprost, Travoprost, and Latanoprost in Korean Patients with Primary Open-Angle Glaucoma or Normal-Tension Glaucoma: A Multicenter Retrospective Cohort Study (LOTUS Study)

This multicenter retrospective cohort study compared the effectiveness and safety of long-term tafluprost, travoprost, or latanoprost in patients with primary open-angle glaucoma (POAG) or normal-tension glaucoma (NTG). Data were extracted from electronic medical records of 300 patients treated with tafluprost, travoprost, or latanoprost for >6 months. Propensity matching for age and sex was used for effectiveness and safety comparisons. The primary endpoint was visual field (VF) progression via mean deviation (MD) slope. Secondary endpoints were change of MD, intraocular pressure, pattern standard deviation, VF index, and advanced glaucoma intervention study score. Treatment-related adverse events (AEs) were also compared between groups. Overall, 216 POAG or NTG patients were matched into Match Set 1 (72 patients/group), and 177 NTG-only patients in Match Set 2 (59 patients/group) according to: age (mean: 61, 62 years) and sex (male: 53, 56%). There were no statistically significant between-group differences regarding MD slope (p = 0.413, p = 0.374 in Match Sets 1 and 2, respectively). There were no significant between-group differences/tendencies regarding secondary endpoints. No AEs were serious, and there were no significant between-group differences regarding reported AEs. In patients with POAG or NTG, long-term tafluprost, travoprost, or latanoprost showed similar effects. All three prostaglandin analogs had good long-term safety profiles.

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Severe Primary Open-Angle Glaucoma and Agricultural Profession: A Retrospective Cohort Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph19020926 ◽

2022 ◽

Vol 19 (2) ◽

pp. 926

Author(s):

Mathilde Grosselin ◽

Leila Bouazzi ◽

Thomas Ferreira de Moura ◽

Carl Arndt ◽

Maxime Thorigny ◽

...

Keyword(s):

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Univariate Analysis ◽

Secondary Outcome ◽

Filtering Surgery ◽

Open Angle ◽

Number Of Patients

While exposure to pesticides is a known risk factor for neurodegenerative brain diseases, little is known about the influence of environment on glaucoma neuropathy. We aimed to determine whether farmers are at higher risk of developing severe primary open-angle glaucoma (POAG). This retrospective cohort study (tertiary referral center, Reims University Hospital, France) included patients diagnosed with POAG in the last two years. Univariate analysis and adjusted multivariate logistic regression were performed to evaluate the association between agricultural profession and all recorded data. Glaucoma severity (primary outcome) and the number of patients who underwent filtering surgery (secondary outcome) were analyzed. In total, 2065 records were screened, and 772 patients were included (66 in the farmer group and 706 in the nonfarmer group). The risk of severe glaucoma was higher in the farmer group (adjusted odds ratio (aOR) 1.87, p = 0.03). More patients underwent filtering surgery in the farmer group in univariate analysis (p = 0.02) but with no statistical significance after adjustment (p = 0.08). These results suggest pesticide exposure may be a factor accelerating the neurodegeneration in POAG, although a direct link between the agricultural profession and the disease requires further extended studies to be demonstrated.

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Comparison between high and low potency statins in the incidence of open-angle glaucoma: A retrospective cohort study in Japanese working-age population

PLoS ONE ◽

10.1371/journal.pone.0237617 ◽

2020 ◽

Vol 15 (8) ◽

pp. e0237617

Author(s):

Nobuhiro Ooba ◽

Rira Iwahashi ◽

Akiko Nogami ◽

Toshimitsu Nakayama ◽

Atsushi Kanno ◽

...

Keyword(s):

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Open Angle Glaucoma ◽

Open Angle ◽

Working Age ◽

Working Age Population

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Study of intraocular pressure and ways to prevent its increase in patients with primary open-angle glaucoma in long-term periods after phacoemulsification

Modern technologies in ophtalmology ◽

10.25276/2312-4911-2019-2-82-86 ◽

2019 ◽

pp. 82-86

Author(s):

E.L. Sorokin ◽

◽

N.V. Postupaeva ◽

Keyword(s):

Intraocular Pressure ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Open Angle

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Problems of treatment of primary openangle glaucoma in combination with thrombosis of the central retinal vein

GlaucomaNews ◽

10.25276/2227-8281-1-65-69 ◽

2020 ◽

pp. 65-69

Author(s):

T.E. Lipatkina ◽

◽

Е.V. Karlova ◽

A.V. Zolotarev ◽

◽

...

Keyword(s):

Macular Edema ◽

Primary Open Angle Glaucoma ◽

Antihypertensive Drugs ◽

Open Angle Glaucoma ◽

Vascular Wall ◽

Open Angle ◽

Retinal Edema ◽

Long Term Preservation ◽

Central Retinal Vein

Patients with primary open-angle glaucoma (POAG) and ophthalmic hypertension have an increased likelihood of developing occlusions (thrombosis) of the central retinal vein. Different groups of antihypertensive drugs differ in their mechanism of action and may affect concomitant ocular pathology, in particular, retinal edema, which occurs, for example, in occlusion of the central retinal vein. Used in most patients with glaucoma, prostaglandin analogs can contribute to the long-term preservation of macular edema due to the effect on the permeability of the vascular wall. Preparations of other pharmacological groups, reducing the production of aqueous humor, on the contrary, may contribute to its regression. Therefore, the question of choosing a drug for antihypertensive therapy in patients with primary open-angle glaucoma and concomitant macular edema is relevant and is for further study.

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