scholarly journals Visual Evoked Potentials as Potential Biomarkers of Visual Function in Patients with Primary Sjögren’s Syndrome

2021 ◽  
Vol 10 (18) ◽  
pp. 4196
Author(s):  
Edyta Dziadkowiak ◽  
Agata Sebastian ◽  
Malgorzata Wieczorek ◽  
Anna Pokryszko-Dragan ◽  
Marta Madej ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Evoked Potentials ◽  
Visual Evoked Potentials ◽  
Visual Pathway ◽  
Primary Sjögren’S Syndrome ◽  
Implicit Time ◽  
Primary Sjogren’S Syndrome ◽  
The Central Nervous System ◽  
Visual Evoked

Visual evoked potentials (VEP) are changes in potentials that arise in the central nervous system. In the interpretation of the VEP test results, it is assumed that the elongation of the latency time is caused by the demyelination of the nerve fibers, and the axon damage is responsible for the decrease in the amplitude. The observed VEP deviations are not specific for specific diseases, but indicate disturbances in visual conductivity. VEP may play a diagnostic role in the early detection of visual involvement. The aim of the study was the functioning of visual pathway assessment on the basis of visual evoked potentials (VEP) examination, in patients with primary Sjögren’s Syndrome (pSS), without focal symptoms of central nervous system disorder. The effect of disease activity, as assessed by clinical parameters and antibody levels (anti-Ro52, SSA, and SSB), on the central nervous system was also evaluated. Thirty-two consecutive patient with pSS (31 females, 1 male) were included in the study. VEP was performed at baseline, and after 6 (T6) years. Their results were compared longitudinally between the baseline and T6, depending on the duration of the disease and treatment. The immunological activity of pSS was also analyzed. The group of patients showed a significant prolongation of the P100 implicit time (105.5 ± 5.1 vs. 100.6 ± 3.9; p = 0.000) and a significant higher the P100-N145 amplitude (12.3 ± 4.1 vs. 9.4 ± 3.0; p = 0.000). Abnormalities in electrophysiological parameters of VEP at baseline correlated with presentation of anti-Ro52 antibodies and aching joints. At baseline, the P100 implicit time was shorter for the patients with pSS than for those at T6 (105.50 ± 5.1 vs. 109.37 ± 5.67; p = 0.002). pSS patients without CNS involvement presented with dysfunction of visual pathway, as revealed by VEP abnormalities. Relationships were found between VEP parameters and with present of anti-Ro52 antibodies and aching joints. VEP may be a useful method for assessment and monitoring of subclinical visual deficit in the course of pSS.

Colour and brightness coding in the central nervous system: theoretical aspects and visual evoked potentials to homogeneous red and green stimuli

1986 ◽  
Vol 227 (1246) ◽  
pp. 53-66 ◽  
Keyword(s):  
Central Nervous System ◽  
Evoked Potentials ◽  
Visual Evoked Potentials ◽  
Colour Vision ◽  
Striate Cortex ◽  
Colour Change ◽  
Cortical Cells ◽  
The Central Nervous System ◽  
X Cells ◽  
Visual Evoked

We designed visual evoked potentials experiments to study the differential aspects of colour and brightness coding in man. The substitution of equally bright red and green stimuli for a background yellow was investigated and compared with different luminance increments and decrements of red and green. A dominant N87 component was found for a colour change from yellow to brighter red colours, which was less pronounced for green and absent for yellow luminance changes. It is also absent for pure red luminance increments and green luminance changes, but reappears with red luminance decrements or red-offset. The data are discussed within the framework of a new concept of how the visual system fuses red-green information and black-white border information. Retinal X-cells can transmit colour and high spatial fre­quency achromatic information simultaneously by encoding only the presence of edges (a. c.) for the black-white stimuli and the presence of both edges (a. c.) and uniform areas of colour (d. c.) for red-green stimuli. Phylogenetically this kind of information transmission enables colour vision to be implemented in a retina such as the cat’s by adding only a second class of cones. Barlow’s economy principle will be violated for colour in the periphery, but restored early in the striate cortex where there is an early decoding of the combined chromatic and achromatic information by the concentric double opponent cells. The N87 behaviour correlates with the proposed discharge of peripheral X-type cells, but not with the discharge of cortical double opponent concentric or simple cells, which no longer respond to homogeneous colour stimuli. It is suggested that N87 may be generated by geniculate afferents in the dendritic arborization of cortical cells, reflecting the behaviour of peripheral units, and thus the violation of the economy principle, rather than the next step in cortical processing. The early cortical restoration of the economy principle is supported by the absence of any further dissociated behaviour for colour and brightness in later components.

Effects of Alcohol on Evoked Potentials of Various Parts of the Central Nervous System of Cat

1968 ◽  
Vol 29 (1) ◽  
pp. 20-37 ◽  
Author(s):  
Raoul DiPerri ◽  
Anant Dravid ◽  
Arlene Schweigerdt ◽  
Harold E. Himwich
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Evoked Potentials ◽  
The Central Nervous System

Neurophysiological and morphological effects in the post-exposure vibration period during experimental modeling

2019 ◽  
pp. 284-290
Author(s):  
Natalya L. Yakimova ◽  
Vladimir A. Pankov ◽  
Aleksandr V. Lizarev ◽  
Viktor S. Rukavishnikov ◽  
Marina V. Kuleshova ◽  
...  
Keyword(s):  
Nervous System ◽  
Evoked Potentials ◽  
Experimental Model ◽  
Visual Evoked Potentials ◽  
The Body ◽  
Behavioral Activity ◽  
Contact Period ◽  
Vibration Exposure ◽  
Visual Evoked

Introduction. Vibration disease continues to occupy one of the leading places in the structure of professional pathology. In workers after the termination of contact with vibration generalization and progression of violations in an organism is noted. The pathogenetic mechanisms of the progredient course of disturbances in the nervous system in the post-contact period of vibration exposure remain insufficiently studied.The aim of the study was to test an experimental model of vibration exposure to assess the neurophysiological and morphological effects of vibration in rats in the dynamics of the post-contact period.Materials and methods. The work was performed on 168 white male outbred rats aged 3 months weighing 180–260 g. The vibration effect was carried out on a 40 Hz vibrating table for 60 days 5 times a week for 4 hours a day. Examination of animals was performed after the end of the physical factor, on the 30th, 60th and 120th day of the post-contact period. To assess the long-term neurophysiological and morphofunctional effects of vibration in rats, we used indicators of behavioral reactions, bioelectric activity of the somatosensory zone of the cerebral cortex, somatosensory and visual evoked potentials, parameters of muscle response, morphological parameters of nervous tissue.Results. In the dynamics of the post-contact period observed the preservation of violations of tentatively research, motor and emotional components of behavior. In the Central nervous system instability of activity of rhythms of an electroencephalogram, decrease in amplitude of visual evoked potentials, lengthening of latency of somatosensory evoked potentials, decrease in total number of normal neurons and astroglia is established. In the peripheral nervous system remained changes in indicators: increasing duration and latency, reducing the amplitude of the neuromuscular response.Conclusions: The experimental model allows us to study the long-term neurophysiological and morphological effects of vibration on the body. The formation and preservation of changes in behavioral activity, neurophysiological and morphological effects of vibration from the 30th to the 120th day of the post-contact period were confirmed.

Pattern-reversal visual evoked potentials in patients with hydrocephalus

1985 ◽  
Vol 62 (2) ◽  
pp. 234-237 ◽  
Author(s):  
Shakir M. Alani
Keyword(s):  
Evoked Potentials ◽  
Visual Evoked Potentials ◽  
Right Hemisphere ◽  
Visual Pathway ◽  
Pattern Reversal ◽  
Field Stimulation ◽  
Content Type ◽  
Clinical Methods ◽  
The Right ◽  
Visual Evoked

✓ Pattern-reversal visual evoked potentials (VEP's) in response to whole- and half-field stimulation were studied in 10 patients with hydrocephalus. Abnormalities consistent with optic nerve dysfunction were recorded in four patients. Two patients had response asymmetry to half-field stimulation, which suggested dysfunction of the visual pathway in the right hemisphere. The remaining four patients had normal responses. Measurement of VEP's was repeated after the surgical treatment of hydrocephalus in four patients, and showed marked improvement in two of the three patients with preoperative abnormalities. This study suggests that, in patients with hydrocephalus, VEP's are more sensitive than clinical methods in detecting visual pathway dysfunction and that they can be useful in the follow-up monitoring of surgically treated hydrocephalic patients.

Atypical case of primary sjögren’s syndrome with psychiatric disorder

2021 ◽  
Vol 2 (3) ◽  
Author(s):  
Chun-guang LI ◽  
◽  
Huan-min LI ◽  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Psychiatric Disorder ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
Sjögren‘S Syndrome

Primary Sjögren’s Syndrome (PSS) is a systemic autoimmune disorder characterized by chronic inflammation of exocrine glands. Neurological manifestations are sometimes found in patients with PSS, and both the Central Nervous System (CNS) and Peripheral Nervous System (PNS) can be involved. Psychiatric disorder is a rare manifestation caused by PSS. Herein, we report a 67-year-old woman admitted from the department of neurology for further investigations of progressive psychiatric abnormalities. High titers (1:320) of Antinuclear Antibodies (ANA) and antibodies against SSA and Rheumatoid Factor (RF) were detected. Rheumatology review revealed a history of Sicca symptoms and her Schirmer’s test was positive. This lead to the diagnosis of CNS complications associated with PSS. She had an excellent response to intravenous methylprednisolone followed by oral prednisolone and intravenous immunoglobulin infusions. This case highlights that CNS involvement can precede the diagnosis of PSS. For a patient with psychiatric disorder, attention should be paid to screening for accompanying PSS, especially in female patients. Keywords: Primary Sjögren syndrome; Autoimmune disease; Neurological involvement; Central nervous system; Psychiatric disorder.

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