scholarly journals Differences between Mycobacterium chimaera and tuberculosis Using Ocular Multimodal Imaging: A Systematic Review

2021 ◽  
Vol 10 (21) ◽  
pp. 4880
Author(s):  
Sandrine Anne Zweifel ◽  
Nastasia Foa ◽  
Maximilian Robert Justus Wiest ◽  
Adriano Carnevali ◽  
Katarzyna Zaluska-Ogryzek ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Multimodal Imaging ◽  
Delayed Diagnosis ◽  
Response To Treatment ◽  
Fundus Photography ◽  
Ocular Infection ◽  
Wide Field ◽  
Optical Coherence ◽  
Imaging Data

Due to their non-specific diagnostic patterns of ocular infection, differential diagnosis between Mycobacterium (M.) chimaera and tuberculosis can be challenging. In both disorders, ocular manifestation can be the first sign of a systemic infection, and a delayed diagnosis might reduce the response to treatment leading to negative outcomes. Thus, it becomes imperative to distinguish chorioretinal lesions associated with M. chimaera, from lesions due to M. tuberculosis and other infectious disorders. To date, multimodal non-invasive imaging modalities that include ultra-wide field fundus photography, fluorescein and indocyanine green angiography, optical coherence tomography and optical coherence tomography angiography, facilitate in vivo examination of retinal and choroidal tissues, enabling early diagnosis, monitoring treatment response, and relapse detection. This approach is crucial to differentiate between active and inactive ocular disease, and guides clinicians in their decisional-tree during the patients’ follow-up. In this review, we summarized and compared the available literature on multimodal imaging data of M. chimaera infection and tuberculosis, emphasizing similarities and differences in imaging patterns between these two entities and highlighting the relevance of multimodal imaging in the management of the infections.

scholarly journals Multimodal Imaging in AIDS-Related Ocular Cryptococcosis

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Maria Fernanda Flores Herrera ◽  
Nicolas Dauby ◽  
Evelyne Maillart ◽  
Agnes Libois ◽  
Alberto Papaleo ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Indocyanine Green ◽  
Multimodal Imaging ◽  
Critical Role ◽  
Fundus Photography ◽  
Optical Coherence ◽  
Ocular Manifestations ◽  
Baseline Evaluation ◽  
Almost All

Purpose. To report multimodal imaging findings in two cases of AIDS-related cryptococcal chorioretinitis associated with uveitis and vasculitis. Methods. Findings on clinical examination, color fundus photography, fluorescein and indocyanine green angiographies, and optical coherence tomography. Patients. Both patients were diagnosed with Cryptococcus neoformans meningitis in the setting of untreated HIV infection with CD4+ T cell count < 100 / m m 3 . Ocular manifestations occurred during the course of the antifungal therapy for meningitis. Results. In both cases, fundus showed vitritis. Fluorescein angiography allowed the characterization of vasculitis lesions, and indocyanine green angiography indicated choroidal involvement. In combination with optical coherence tomography, ICG and FA allowed the assessment of treatment response. Conclusion. These two cases reveal the potential of C. neoformans to infect almost all ocular structures and the critical role of multimodal imaging in baseline evaluation and in the follow-up of patients.

scholarly journals Integrating photoacoustic microscopy, optical coherence tomography, OCT angiography, and fluorescence microscopy for multimodal imaging

2020 ◽  
Vol 245 (4) ◽  
pp. 342-347 ◽  
Author(s):  
Arash Dadkhah ◽  
Shuliang Jiao
Keyword(s):  
Optical Coherence Tomography ◽  
Fluorescence Microscopy ◽  
Multimodal Imaging ◽  
Imaging System ◽  
Optical Resolution ◽  
Biological Tissues ◽  
Large Field ◽  
Optical Coherence ◽  
Photoacoustic Microscopy

We have developed a multimodal imaging system, which integrated optical resolution photoacoustic microscopy, optical coherence tomography, optical coherence tomography angiography, and confocal fluorescence microscopy in one platform. The system is able to image complementary features of a biological sample by combining different contrast mechanisms. We achieved fast imaging and large field of view by combining optical scanning with mechanical scanning, similar to our previous publication. We have demonstrated the capability of the multimodal imaging system by imaging a mouse ear in vivo. Impact statement Photoacoustic microscopy-based multimodal imaging technology can provide high-resolution complementary information for biological tissues in vivo. It will potentially bring significant impact on the research and diagnosis of diseases by providing combined structural and functional information.

Multimodal imaging of pre-Descemet corneal dystrophy

2019 ◽  
Vol 30 (5) ◽  
pp. 908-916 ◽  
Author(s):  
Munirah Alafaleq ◽  
Cristina Georgeon ◽  
Kate Grieve ◽  
Vincent M Borderie
Keyword(s):  
Optical Coherence Tomography ◽  
Confocal Microscopy ◽  
Multimodal Imaging ◽  
Case Series ◽  
Corneal Dystrophy ◽  
Spectral Domain ◽  
Optical Coherence ◽  
In Vivo Confocal Microscopy ◽  
Descemet Membrane

Purpose: The aim of this study was to assess structural and histological changes associated with pre-Descemet corneal dystrophy with multimodal in vivo imaging. Methods: Retrospective case series including eight corneas from four unrelated male patients with pre-Descemet corneal dystrophy characterized by the presence of punctiform gray opacities located just anterior to the Descemet membrane at slit-lamp examination of both eyes. In vivo confocal microscopy images were obtained in the central, paracentral, and peripheral corneal zones from the superficial epithelial cell layer down to the corneal endothelium in both eyes. Spectral domain optical coherence tomography scans (central and limbal zones) and mapping of both corneas were acquired. Results: Diffuse small extracellular stromal deposits, presence of enlarged hyperreflective keratocytes in the posterior stroma with either hyperreflective or hyporeflective intracellular dots, and presence of activated keratocytes in the very anterior stroma were observed in all corneas with in vivo confocal microscopy. Spectral domain optical coherence tomography scans showed a hyperreflective line anterior to Descemet’s membrane running from limbus to limbus and associated with a second thinner hyperreflective line just beneath Bowman’s layer. Fine hyperreflective particles were observed in the posterior, mid, and anterior stroma on optical coherence tomography scans. Conclusion: The clinical presentation and structural anomalies found in isolated sporadic pre-Descemet corneal dystrophy are in favor of a degenerative process affecting corneal keratocytes with no epithelial or endothelial involvement. The maximum damage is found just anterior to the Descemet membrane resulting in pre-Descemet membrane location of stromal opacities. Multimodal imaging of cornea reveals that the disorder affects the whole stroma and it permits better understanding of pre-Descemet corneal dystrophy pathophysiology together with ascertained diagnosis.

scholarly journals Cycloid scanning for wide field optical coherence tomography endomicroscopy and angiography in vivo

Optica ◽  
2018 ◽  
Vol 5 (1) ◽  
pp. 36 ◽  
Author(s):  
Kaicheng Liang ◽  
Zhao Wang ◽  
Osman O. Ahsen ◽  
Hsiang-Chieh Lee ◽  
Benjamin M. Potsaid ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Wide Field ◽  
Optical Coherence

Wide-Field Optical Coherence Tomography of the Choroid In Vivo

2008 ◽  
Vol 50 (4) ◽  
pp. 1856-1863 ◽  
Author(s):  
B. Povazay ◽  
B. Hermann ◽  
B. Hofer ◽  
V. Kajic ◽  
E. Simpson ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Wide Field ◽  
Optical Coherence

scholarly journals Multimodal imaging of a vascularized idiopathic epiretinal membrane

2020 ◽  
pp. 112067212098252
Author(s):  
Rodrigo Anguita ◽  
Hagar Khalid ◽  
Cristina Arpa ◽  
Janice Roth ◽  
Bishwanath Pal ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Retinal Detachment ◽  
Fluorescein Angiography ◽  
Epiretinal Membrane ◽  
Multimodal Imaging ◽  
Fundus Photography ◽  
Vascular Endothelial ◽  
Optical Coherence ◽  
Idiopathic Epiretinal Membrane ◽  
Endothelial Growth Factor

Purpose: To report a case of vascularized idiopathic epiretinal membrane including the multimodal imaging. Methods: Findings on clinical examination, color fundus photography, spectral-domain optical coherence tomography, optical coherence tomography angiography, and fluorescein angiography. Results: Sixty-three-year-old woman with a previous rhegmatogenous retinal detachment (RRD) who presented with an asymptomatic idiopathic neovascular complex below an epiretinal membrane. It was assessed with fluorescein angiography, OCT and OCT-A. The vascularized ERM was already present previously to the retinal detachment. Conclusion: Our case report describes an example of idiopathic epiretinal membrane complicated by neovascularization; we hypothesized hypertension could be one of the factors in this case, as it may lead to decreased retinal perfusion and upregulation in vascular endothelial growth factor (VEGF). Multimodal imaging can help in detecting neovascularized ERM.

scholarly journals The Value of Anterior Segment Optical Coherence Tomography in Different Types of Corneal Infections: An Update

2021 ◽  
Vol 10 (13) ◽  
pp. 2841
Author(s):  
Ahmed A. Abdelghany ◽  
Francesco D’Oria ◽  
Jorge Alio Del Barrio ◽  
Jorge L. Alio
Keyword(s):  
Optical Coherence Tomography ◽  
Imaging Modality ◽  
Wide Spectrum ◽  
Anterior Segment ◽  
Corneal Edema ◽  
Response To Treatment ◽  
Optical Coherence ◽  
Slit Lamp ◽  
Cross Sectional

Anterior segment optical coherence tomography (AS-OCT) is a modality that uses low-coherence interferometry to visualize and assess anterior segment ocular features, offering several advantages of being a sterile and noncontact modality that generates high-resolution cross-sectional images of the tissues. The qualitative and quantitative information provided by AS-OCT may be extremely useful for the clinician in the assessment of a wide spectrum of corneal infections, guiding in the management and follow-up of these patients. In clinical practice, infections are routinely evaluated with slit-lamp biomicroscopy, an examination and imaging modality that is limited by the physical characteristics of light. As a consequence, the depth of pathology and the eventually associated corneal edema cannot be accurately measured with the slit-lamp. Therefore, it represents a limit for the clinician, as in vivo information about corneal diseases and the response to treatment is limited. Resolution of corneal infection is characterized by an early reduction in corneal edema, followed by a later reduction in infiltration: both parameters can be routinely measured with standardized serial images by AS-OCT.

scholarly journals Scalable wide-field optical coherence tomography-based angiography for in vivo imaging applications

2016 ◽  
Vol 7 (5) ◽  
pp. 1905 ◽  
Author(s):  
Jingjiang Xu ◽  
Wei Wei ◽  
Shaozhen Song ◽  
Xiaoli Qi ◽  
Ruikang K. Wang
Keyword(s):  
Optical Coherence Tomography ◽  
In Vivo Imaging ◽  
Wide Field ◽  
Optical Coherence
Sign in / Sign up

Export Citation Format

Share Document