scholarly journals Multimodal Imaging in AIDS-Related Ocular Cryptococcosis

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Maria Fernanda Flores Herrera ◽  
Nicolas Dauby ◽  
Evelyne Maillart ◽  
Agnes Libois ◽  
Alberto Papaleo ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Indocyanine Green ◽  
Multimodal Imaging ◽  
Critical Role ◽  
Fundus Photography ◽  
Optical Coherence ◽  
Ocular Manifestations ◽  
Baseline Evaluation ◽  
Almost All

Purpose. To report multimodal imaging findings in two cases of AIDS-related cryptococcal chorioretinitis associated with uveitis and vasculitis. Methods. Findings on clinical examination, color fundus photography, fluorescein and indocyanine green angiographies, and optical coherence tomography. Patients. Both patients were diagnosed with Cryptococcus neoformans meningitis in the setting of untreated HIV infection with CD4+ T cell count < 100 / m m 3 . Ocular manifestations occurred during the course of the antifungal therapy for meningitis. Results. In both cases, fundus showed vitritis. Fluorescein angiography allowed the characterization of vasculitis lesions, and indocyanine green angiography indicated choroidal involvement. In combination with optical coherence tomography, ICG and FA allowed the assessment of treatment response. Conclusion. These two cases reveal the potential of C. neoformans to infect almost all ocular structures and the critical role of multimodal imaging in baseline evaluation and in the follow-up of patients.

scholarly journals Multimodal imaging of a vascularized idiopathic epiretinal membrane

2020 ◽  
pp. 112067212098252
Author(s):  
Rodrigo Anguita ◽  
Hagar Khalid ◽  
Cristina Arpa ◽  
Janice Roth ◽  
Bishwanath Pal ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Retinal Detachment ◽  
Fluorescein Angiography ◽  
Epiretinal Membrane ◽  
Multimodal Imaging ◽  
Fundus Photography ◽  
Vascular Endothelial ◽  
Optical Coherence ◽  
Idiopathic Epiretinal Membrane ◽  
Endothelial Growth Factor

Purpose: To report a case of vascularized idiopathic epiretinal membrane including the multimodal imaging. Methods: Findings on clinical examination, color fundus photography, spectral-domain optical coherence tomography, optical coherence tomography angiography, and fluorescein angiography. Results: Sixty-three-year-old woman with a previous rhegmatogenous retinal detachment (RRD) who presented with an asymptomatic idiopathic neovascular complex below an epiretinal membrane. It was assessed with fluorescein angiography, OCT and OCT-A. The vascularized ERM was already present previously to the retinal detachment. Conclusion: Our case report describes an example of idiopathic epiretinal membrane complicated by neovascularization; we hypothesized hypertension could be one of the factors in this case, as it may lead to decreased retinal perfusion and upregulation in vascular endothelial growth factor (VEGF). Multimodal imaging can help in detecting neovascularized ERM.

scholarly journals Differences between Mycobacterium chimaera and tuberculosis Using Ocular Multimodal Imaging: A Systematic Review

2021 ◽  
Vol 10 (21) ◽  
pp. 4880
Author(s):  
Sandrine Anne Zweifel ◽  
Nastasia Foa ◽  
Maximilian Robert Justus Wiest ◽  
Adriano Carnevali ◽  
Katarzyna Zaluska-Ogryzek ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Multimodal Imaging ◽  
Delayed Diagnosis ◽  
Response To Treatment ◽  
Fundus Photography ◽  
Ocular Infection ◽  
Wide Field ◽  
Optical Coherence ◽  
Imaging Data

Due to their non-specific diagnostic patterns of ocular infection, differential diagnosis between Mycobacterium (M.) chimaera and tuberculosis can be challenging. In both disorders, ocular manifestation can be the first sign of a systemic infection, and a delayed diagnosis might reduce the response to treatment leading to negative outcomes. Thus, it becomes imperative to distinguish chorioretinal lesions associated with M. chimaera, from lesions due to M. tuberculosis and other infectious disorders. To date, multimodal non-invasive imaging modalities that include ultra-wide field fundus photography, fluorescein and indocyanine green angiography, optical coherence tomography and optical coherence tomography angiography, facilitate in vivo examination of retinal and choroidal tissues, enabling early diagnosis, monitoring treatment response, and relapse detection. This approach is crucial to differentiate between active and inactive ocular disease, and guides clinicians in their decisional-tree during the patients’ follow-up. In this review, we summarized and compared the available literature on multimodal imaging data of M. chimaera infection and tuberculosis, emphasizing similarities and differences in imaging patterns between these two entities and highlighting the relevance of multimodal imaging in the management of the infections.

scholarly journals Multimodal Imaging observation of Bietti crystalline dystrophy progression

2020 ◽  
Author(s):  
Shengjuan Zhang ◽  
Qian Li ◽  
Lifei Wang ◽  
XiaoYan Peng
Keyword(s):  
Optical Coherence Tomography ◽  
Multimodal Imaging ◽  
Vision Loss ◽  
Genetic Disorder ◽  
Fundus Photography ◽  
Optical Coherence ◽  
Macular Area ◽  
Imaging Characteristics ◽  
Bietti Crystalline Dystrophy ◽  
Peripheral Area

Abstract Background Bietti crystalline dystrophy (BCD) is an autosomal recessive genetic disorder that causes progressive vision loss in patients. Here, we observed the imaging characteristics of BCD development using a multimodal imaging model. Methods Color fundus photography, fundus autofluorescence (FAF), infrared autofluorescence (IRAF), fundus fluorescein angiography (FFA), and spectral domain optical coherence tomography (SD-OCT) were used for observation of 8 eyes of 4 patients (P1-P4) with BCD. Results Color fundus photography showed a decrease in the number of crystalline deposits in all 8 eyes. P1 and P2 showed expanded lesion and hypo-AF areas, and IRAF images revealed choroid macrovascularitis in the hypo-IRAF region. P1’s lesion edge showed hyper-AF and (fewer) hyper-IRAF spots. P2’s lesion edge showed hyper-AF but no hyper-IRAF spots. P3 and P4 showed patchy hypo-AF areas that were enlarged and partially merged together, as well as small numbers of hyper-AF spots, but no hyper-IRAF spots. FFA showed enlargement of the lesion area. P1 and P2 showed expanded hypo-fluorescence in the posterior pole. A mottled fluorescence around the hypo-fluorescence and at the periphery, expanding to the middle periphery. P3 both eyes contained a large hypo-fluorescence area around macular area and in the middle peripheral area, with mottled fluorescence in the macular area and the peripheral area. P4 showed slight residual mottled fluorescence, whereas the entire fundus showed a large area of choroid macrovascular fluorescence. P3 and P4 showed a significant reduction in the retinal mottled fluorescence area and more clearer choroid macrovascular fluorescence, similar to the early Indocyanine green angiography (ICGA) images. Optical coherence tomography (OCT) revealed retinal and choroidal thinning, progressive loss of the outer nuclear layer and ellipsoid zone (EZ), and shortening of the choroid macrovascular diameter. Conclusions BCD disease develops rapidly and can progress significantly in a short time in some cases. FAF, IRAF, and OCT are advantageous non-invasive models for detecting and assessing this disease.

scholarly journals The role of quantitative deep capillary plexus in the pathogenesis of type 3 macular neovascularization: an optical coherence tomography angiography study

2021 ◽  
Author(s):  
Marina Concilio ◽  
Federica Fossataro ◽  
Daniela Montorio ◽  
Mariapaola Giordano ◽  
Gilda Cennamo
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Early Stage ◽  
Study Groups ◽  
Control Group ◽  
Main Role ◽  
Optical Coherence ◽  
Capillary Plexus ◽  
Type 3

Abstract Purpose To quantitatively investigate the role of deep capillary plexus (DCP) in patients affected by type 3 macular neovascularization (MNV), compared to patients with reticular pseudodrusen (RPD) eyes and healthy controls, using optical coherence tomography angiography (OCTA). Methods In this prospective observational study, a total of seventy-eight eyes of 78 patients were included. Group 1 consisted of 40 eyes of 40 patients with stage 1 of type 3 MNV (22 males, 18 females, mean age 73.7, SD ± 6.60) and group 2 included 38 eyes of 38 patients with RPD (17 males, 21 females, mean age 73.2, SD ± 4.55). The control group included 40 eyes of 40 healthy subjects (20 males, 20 females, mean age 71.4, SD ± 6.36 years). We evaluated the retinal vessel density (VD) of superficial capillary plexus (SCP) and deep capillary plexus (DCP) using OCTA. Results Patients with diagnosis of type 3 MNV showed statistically lower values of VD in DCP with respect to controls and to RPD group (p < 0.001), while there were no statistical differences between RPD and control group in macular region. No significant differences in VD of SCP were detected among the three study groups. Conclusion OCTA provides a reproducible, non-invasive detailed quantitative analysis of retinal vascular features and changing in early-stage type 3 MNV patients, which allowed to shed the light on the main role of DCP ischemia in the development of type 3 MNV.

Retinal microcirculation abnormalities in patients with systemic sclerosis: an explorative optical coherence tomography angiography study

Rheumatology ◽  
2021 ◽  
Author(s):  
Adriano Carnevali ◽  
Giuseppe Giannaccare ◽  
Valentina Gatti ◽  
Caterina Battaglia ◽  
Giorgio Randazzo ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Flow Index ◽  
Digital Ulcers ◽  
Optical Coherence ◽  
Vascular Abnormalities ◽  
Capillary Plexus ◽  
Retinal Microcirculation ◽  
Vascular Plexuses

Abstract Objectives To investigate subclinical and clinical abnormalities in retinal and choroidal vascular plexuses in patients with SSc by means of optical coherence tomography angiography (OCT-A). Methods A total of 20 consecutive SSc patients were recruited and compared with 20 healthy subjects. Quantitative analysis of vessel density (VD), choriocapillaris plexus flow index (CCP-FI) and choroidal vascularity index were performed on OCT-A images in the superficial capillary plexus (SCP), deep capillary plexus (DCP) and CCP for all patients. Images were further reviewed by two independent readers for the assessment of qualitative abnormalities, including tortuosity, rarefaction areas, megacapillaries and macular-foveal capillaries. Results The DCP-VD in the whole scan and in the perifoveal, superior, inferior, nasal and temporal regions was significantly lower in the SSc group. The CCP-FI was significantly higher in SSc patients. When comparing SSc patients with and without digital ulcers, significantly decreased SCP-VD was demonstrated in the whole, perifoveal, superior, inferior, temporal and nasal regions. No difference in any of the OCT-A parameters was observed when comparing patients with and without interstitial lung disease. Qualitative analysis of OCT-A revealed at least one abnormality in 95% of patients. Conclusion We showed the ability of OCT-A to disclose early ocular vascular abnormalities in patients with SSc. Our results may represent a hypothesis-generating basis for exploring the potential role of OCT-A in diagnosis, monitoring and prognosis stratification in SSc.

scholarly journals Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent

2004 ◽  
Vol 29 (17) ◽  
pp. 2016 ◽  
Author(s):  
Changhuei Yang ◽  
Laura E. L. McGuckin ◽  
John D. Simon ◽  
Michael A. Choma ◽  
Brian E. Applegate ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Indocyanine Green ◽  
Contrast Agent ◽  
Optical Coherence ◽  
Molecular Contrast
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