scholarly journals Ultrasound Cyclo Plasty for Treatment of Surgery-Naïve Open-Angle Glaucoma Patients: A Prospective, Multicenter, 2-Year Follow-Up Trial

2021 ◽  
Vol 10 (21) ◽  
pp. 4982
Author(s):  
Michele Figus ◽  
Chiara Posarelli ◽  
Marco Nardi ◽  
Ingeborg Stalmans ◽  
Evelien Vandewalle ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Vision Loss ◽  
Open Angle Glaucoma ◽  
Mean Value ◽  
Piezoelectric Transducers ◽  
High Intensity Focused Ultrasound ◽  
Filtering Surgery ◽  
Open Angle ◽  
History Of

Background: The purpose of this prospective study was to evaluate the efficacy and safety of the Ultrasound Cyclo Plasty (UCP) procedure using high-intensity focused ultrasound in surgery-naïve open-angle glaucoma patients. Methods: prospective, non-randomized, single-arm, multicenter clinical trial. Sixty-six eyes with primary open-angle glaucoma, intraocular pressure (IOP) ≥21 mmHg and with no history of filtering surgery were enrolled. Patients were treated by UCP with a therapy probe comprising six piezoelectric transducers, consecutively activated for 8 s each. Complete ophthalmic examination was performed before the procedure, 1 day after the procedure, and 1, 3, 6, 12, 18 and 24 months after the procedure. Primary outcomes were complete success (defined as IOP lowering from baseline ≥20% without additional glaucoma medications) and vision-threatening complications. Secondary outcomes were the presence of complications and the reduction of the number of medications used. Results: IOP was significantly reduced after one procedure (p < 0.05), from a mean pre-operative value of 24.3 ± 2.9 mmHg (n = 2.3 hypotensive medications) to a mean value of 15.9 ± 3.6 mmHg (n = 2.2 hypotensive medications) at 2 years (mean IOP lowering of 33%). Surgical success was achieved in 74% of eyes. Notwithstanding side effects such as transient anterior chamber inflammation, refractive error changes, transient hypotony and macular edema, no major intra or post-operative complications such as phthisis, induced cataract, neovascularization or significant vision loss were observed. Conclusions: Ultrasound Cyclo Plasty is a valuable, effective and well-tolerated procedure to lower IOP in patients with open-angle glaucoma without previous filtering surgery.

scholarly journals Comprehensive Trabectome Outcomes in Surgery-naive Versus Previously Operated Eyes

2018 ◽  
Vol 12 (1) ◽  
pp. 50
Author(s):  
Sameh Mosaed ◽  
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Success Rates ◽  
Medication Usage ◽  
Prospective Data ◽  
Trabectome Surgery ◽  
History Of ◽  
Tube Versus

This study aims to compare the results of trabectome surgery between surgery-naïve eyes and eyes that have previously undergone incisional surgery. Prospective data was collected on the first 20 cases of each new trabectome surgeon. This trabectome dataset was used to create two groups of subjects: surgery-naïve eyes versus eyes with prior incisional surgery. A total of 2,051 eyes were included in the study. These two groups were further broken down into the subtype of glaucoma (primary open angle glaucoma, pigmentary, pseudoexfoliation, uveitic and steroid-induced glaucoma). At 12- and 36-months follow up, success rates, intraocular pressure (IOP) reduction and medication usage were compared between the groups using the Tube versus Trabeculectomy Study criteria for defining success. At 36 months, the IOP of the virgin eyes and the previously operated eyes was 16.3 mmHg versus 15.8 mmHg, respectively. This difference was not statistically significant (p<0.05). Trabectome outcomes are similar in eyes with a history of prior incisional surgery (including failed glaucoma procedures) compared with those that are surgery-naive.

Topical Bimatoprost Insert for Primary Open-Angle Glaucoma and Ocular Hypertension Treatment - A Phase II Controlled Study

2021 ◽  
Vol 18 ◽  
Author(s):  
Francine Rubião ◽  
Alan Cezar Faria Araújo ◽  
João Bernardo Sancio ◽  
Bárbara Silva Nogueira ◽  
Juçara Ribeiro Franca ◽  
...  
Keyword(s):  
Ocular Hypertension ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
T Test ◽  
Controlled Study ◽  
Therapeutic Drug ◽  
Eye Drops ◽  
Open Angle ◽  
Drug Concentrations

Background: The most common treatment for primary open-angle glaucoma (POAG) is the daily use of eye drops. Sustained-release drug delivery systems have been developed to improve patient adherence by achieving prolonged therapeutic drug concentrations in ocular target tissues while limiting systemic exposure. The purpose of this study is to compare the efficacy and safety of bimatoprost inserts with bimatoprost eye drops in patients with POAG and ocular hypertension (OH). Methods: We include OH and POAG patients aged between 40 and 75 years-old. Both OH and POAG patients had intraocular pressure (IOP) greater than 21 and ≤30 mmHg at 9:00 am without glaucoma medication and normal biomicroscopy. Five normal patients with IOP≤14 mmHg constitute the control group. A chitosan-based insert of bimatoprost was placed at the upper conjunctival fornix of the right eye. In the left eye, patients used one drop of LumiganTM daily at 10:00 pm. For statistical analysis, we used a two-way analysis of variance (ANOVA), Student t-test, and paired t-test. Results: Sixteen POAG and 13 OH patients with a mean age of 61 years were assessed. In both eyes, IOP reduction was similar during three weeks of follow-up (19.5±2.2 mmHg and 16.9±3.1 mmHg), insert, and eye drop, respectively; P=0.165). The percentage of IOP reduction in the third week was 30% for insert and 35% for eye drops (P=0.165). No intolerance or discomfort with the insert was reported. Among the research participants, 58% preferred the use of the insert while 25% preferred eye drops, and 17% reported no preference. Conclusions: Bimatoprost-loaded inserts showed similar efficacy to daily bimatoprost eye drops during three weeks of follow up, without major side effects. This might suggest a possible change in the daily therapeutic regimen for the treatment of POAG and OH.

Sign in / Sign up

Export Citation Format

Share Document