scholarly journals Does Beta-Trace Protein (BTP) Outperform Cystatin C as a Diagnostic Marker of Acute Kidney Injury Complicating the Early Phase of Acute Pancreatitis?

2020 ◽  
Vol 9 (1) ◽  
pp. 205 ◽  
Author(s):  
Justyna Wajda ◽  
Paulina Dumnicka ◽  
Mateusz Sporek ◽  
Barbara Maziarz ◽  
Witold Kolber ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Acute Pancreatitis ◽  
Early Diagnosis ◽  
Cystatin C ◽  
Early Phase ◽  
Kidney Injury ◽  
Serum Samples ◽  
Serum Cystatin C ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Diagnostic Usefulness

Acute pancreatitis (AP) belongs to the commonest acute gastrointestinal conditions requiring hospitalization. Acute kidney injury (AKI) often complicates moderately severe and severe AP, leading to increased mortality. Among the laboratory markers proposed for early diagnosis of AKI, few have been studied in AP, including cystatin C and neutrophil gelatinase-associated lipocalin (NGAL). Beta-trace protein (BTP), a low-molecular-weight glycoprotein proposed as an early marker of decreased glomerular filtration, has never been studied in AP. We investigated the diagnostic usefulness of serum BTP for early diagnosis of AKI complicating AP in comparison to previously studied markers. BTP was measured in serum samples collected over the first three days of hospital stay from 73 adult patients admitted within 24 h of mild to severe AP. Thirteen patients (18%) developed AKI in the early phase of AP. Serum BTP was higher in patients who developed AKI, starting from the first day of hospitalization. Strong correlations were observed between BTP and serum cystatin C but not serum or urine NGAL. On admission, BTP positively correlated with endothelial dysfunction. The diagnostic usefulness of BTP for AKI was similar to cystatin C and lower than NGAL. Increased BTP is an early predictor of AKI complicating AP. However, it does not outperform cystatin C or NGAL.

Neutrophil gelatinase-associated lipocalin is a better biomarker than cystatin C for the prediction of imminent acute kidney injury in critically ill patients

2017 ◽  
Vol 55 (2) ◽  
pp. 190-197 ◽  
Author(s):  
Itir Yegenaga ◽  
Fatih Kamis ◽  
Canan Baydemir ◽  
Elizade Erdem ◽  
Koray Celebi ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Acute Kidney Injury ◽  
Intensive Care ◽  
Intensive Care Unit Admission ◽  
Cystatin C ◽  
Kidney Injury ◽  
Failure Criteria ◽  
Serum Cystatin C ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Neutrophil Gelatinase

Aims The prevention of acute kidney injury can be lifesaving for the intensive care unit patients. However, conventional methods are not sufficient for the prediction of the risk of future acute kidney injury. In this study, the promising biomarker, neutrophil gelatinase-associated lipocalin, was compared with cystatin C as an indicator for the risk of future acute kidney injury. Methods One hundred and eighty-three adult patients without chronic kidney disease or renal replacement therapy were included in this study. The plasma and urine concentrations of neutrophil gelatinase-associated lipocalin and cystatin C were assessed on the second day after intensive care unit admission and were followed for seven days to monitor the development of acute kidney injury. Acute kidney injury diagnosis was based on the risk, injury, failure, loss, end-stage renal failure criteria. Results Thirty-four per cent of the patients had acute kidney injury; 17 patients who did not fulfil criteria at the beginning, developed acute kidney injury from days 3 to 7 after admission. The mean serum creatinine on admission did not significantly differ between this and control groups (0.72 ± 0.20 and 0.83 ± 0.21; P = 0.060); however, the serum and urinary neutrophil gelatinase-associated lipocalin concentrations on the second day were significantly different (median: 75.69 [54.18–91.18] and 123.68 [90.89–166.31], P = 0.001; and median: 17.60 [8.56–34.04] and 61.37 [24.59–96.63], P = 0.001). Notably, the 48-h serum cystatin C concentration did not differ. Conclusion Neutrophil gelatinase-associated lipocalin concentrations in the urine and serum on the second day of intensive care unit admission could be used to predict the development of acute kidney injury in the following three to seven days in the intensive care unit; however, the cystatin C concentration did not have predictive value.

scholarly journals Evaluation of Serum Cystatin C as an Early Biomarker of Acute Kidney Injury in Patients with Acute Pancreatitis

2020 ◽  
Vol 24 (9) ◽  
pp. 777-782
Author(s):  
Radhey Shyam ◽  
Rekha Sachan ◽  
ML Patel ◽  
Harish Bharti ◽  
KK Gupta ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Acute Pancreatitis ◽  
Cystatin C ◽  
Kidney Injury ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Early Biomarker

scholarly journals Baseline Serum Cystatin C Is a Potential Predictor for Acute Kidney Injury in Patients with Acute Pancreatitis

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Xue Chai ◽  
Hou-Bao Huang ◽  
Gang Feng ◽  
Yu-Han Cao ◽  
Qing-Shui Cheng ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Acute Pancreatitis ◽  
Cystatin C ◽  
Kidney Injury ◽  
Gamma Glutamyl Transpeptidase ◽  
Serum Cystatin C ◽  
Serum Lipase ◽  
Serum Cystatin ◽  
Baseline Serum ◽  
Potential Predictor

Aims. The study is aimed at studying the incidence of acute kidney injury (AKI) and exploring the potential predictor for AKI in patients with acute pancreatitis. Methods. A retrospective study adopting a stratified cohort sampling design was performed in a cohort of patients (n=237) diagnosed with acute pancreatitis without any renal injury. The following information including age, gender, serum creatinine, serum urea nitrogen, serum uric acid, serum cystatin C, fasting serum glucose, serum amylase, serum lipase, serum choline esterase, total protein, albumin, globulin, total bilirubin, direct bilirubin, total bile acids, glutamic-pyruvic transaminase, glutamic-oxaloacetic transaminase, gamma glutamyl transpeptidase, and alkaline phosphatase were collected from each patient when they were diagnosed with acute pancreatitis. Student t-test was conducted to figure out the difference between patients with and without AKI. Univariate and multivariate logistic regression analyses were used for investigating the predictors for AKI in patients with acute pancreatitis. Results. 18 (7.6%) patients in total had developed AKI among the study group. Compared with patients without AKI (1.01 ± 0.26 mg/L), the level of baseline serum cystatin C (CYS-C) was significantly higher in patients with AKI (3.64 ± 2.17 mg/L, P<0.001). Baseline serum CYS-C (OR=203.594, P<0.001) was the independent and significant predictor for AKI in patients with acute pancreatitis. AKI in patients with acute pancreatitis could be identified with a sensitivity of 88.9% at specificity of 100% (AUC=0.948, 95% CI 0.879–1.000) by baseline serum CYS-C (cut-off value = 1.865 mg/L). Conclusions. Baseline serum CYS-C shall be adopted to predict the potential risk of AKI in patients with acute pancreatitis.

scholarly journals Evaluation of serum and urine neutrophil gelatinase-associated lipocalin and cystatin C as biomarkers of acute kidney injury in horses

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Natalia Siwińska ◽  
Agnieszka Żak ◽  
Urszula Pasławska
Keyword(s):  
At Risk ◽  
Acute Kidney Injury ◽  
Cystatin C ◽  
Clinical Signs ◽  
Kidney Injury ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Neutrophil Gelatinase ◽  
Urinary Cystatin C

Abstract Introduction Diagnosis of acute kidney injury (AKI) in horses is difficult at the subclinical stage, due to nonspecific clinical signs. The aim of this study was to evaluate the concentrations of selected serum and urinary biomarkers in healthy horses, horses at risk of AKI, and those with clinical AKI. Material and Methods Thirty healthy horses, 30 horses at risk of AKI and 11 horses with clinical AKI and azotaemia were included in the study. Serum and urinary neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C were measured using commercially available enzyme immunoassay tests. Results The median and (in parentheses) first and third quartile concentrations of selected biomarkers in healthy horses, horses at risk of AKI and horses with AKI were respectively as follows: serum cystatin C – 0.25 (0.19–0.37), 0.23 (0.15–0.37) and 0.61 (0.37–1.13) mg/L; serum NGAL – 50.5 (38.8–58.8), 51.1 (40.4–66.9) and 98.1 (59.4–128.2) ng/mL; urinary NGAL – 20.7 (17.9–24.5), 32.3 (32.7–55.8) and 36.6 (26.8–89.9) ng/mL; and urinary cystatin C – 0.1 (0.07–0.13), 0.13 (0.1–0.2) and 0.34 (0.22–0.37) mg/L. There were significant differences in the concentration of all biomarkers between the healthy and AKI-affected horses. Conclusion Horses with AKI all had biomarker concentrations higher than the healthy horses. None of the biomarkers made azotaemia recognisable in all affected horses. The obtained results indicate the need to create a serum and urinary biomarker panel to detect AKI.

scholarly journals The Use of Plasma and Urine Neutrophil Gelatinase Associated Lipocalin (NGAL) and Cystatin C in Early Diagnosis of Septic Acute Kidney Injury in Critically Ill Patients

2013 ◽  
Vol 34 (4) ◽  
pp. 237-246 ◽  
Author(s):  
Müge Aydoğdu ◽  
Gül Gürsel ◽  
Banu Sancak ◽  
Serpil Yeni ◽  
Gülçin Sarı ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Early Diagnosis ◽  
Critically Ill ◽  
Cystatin C ◽  
Critically Ill Patients ◽  
Kidney Injury ◽  
Urinary Ngal ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Septic Acute Kidney Injury ◽  
Neutrophil Gelatinase

Aim: To assess and compare the roles of plasma and urine concentrations of neutrophil gelatinase associated lipocalin (NGAL) and Cystatin C for early diagnosis of septic acute kidney injury (AKI) in adult critically ill patients.Methods: Patients were divided into three groups as sepsis-non AKI, sepsis-AKI and non sepsis-non AKI. Plasma samples for NGAL and Cystatin C were determined on admission and on alternate days and urinary samples were collected for every day until ICU discharge.Results: One hundred fifty one patients were studied; 66 in sepsis-non AKI, 63 in sepsis-AKI, 22 in non-sepsis-non-AKI groups. Although plasma NGAL performed less well (AUC 0.44), urinary NGAL showed significant discrimination for AKI diagnosis (AUC 0.80) with a threshold value of 29.5 ng/ml (88% sensitivity, 73% specificity). Both plasma and urine Cystatin C worked well for the diagnosis of AKI (AUC 0.82 and 0.86, thresholds 1.5 and 0.106 mg/L respectively).Conclusion: Plasma and urinary Cystatin C and urinary NGAL are useful markers in predicting AKI in septic critically ill patients. Plasma NGAL raises in patients with sepsis in the absence of AKI and should be used with caution as a marker of AKI in septic ICU patients.

scholarly journals Role of Serum Cystatin C in Early Diagnosis of Acute Kidney Injury in Neonates with Bronchopulmonary Dysplasia

2021 ◽  
pp. 38-48
Author(s):  
Sara Mohamed Elashry ◽  
Maher Ahmed Abdelhafez ◽  
Mostafa Mohamed Awny ◽  
Nahed Mohamed Elwan ◽  
Hamed Mohamed Elsharkawy
Keyword(s):  
Acute Kidney Injury ◽  
Early Detection ◽  
Early Diagnosis ◽  
Serum Creatinine ◽  
Bronchopulmonary Dysplasia ◽  
Cystatin C ◽  
Resistive Index ◽  
Kidney Injury ◽  
Serum Cystatin C ◽  
Serum Cystatin

Background: The neonate is more susceptible to acute kidney injury (AKI) than others due to functional and developmental immaturity, hemodynamic changes that occur at birth, and possibility of hypovolemia due to increased insensible water losses. The aim of this work was early detection of the occurrence of AKI through measurement of serum cystatin C (CysC) and assessment of renal function in patients with bronchopulmonary dysplasia (BPD) in order to initiate early and appropriate therapeutic measures as indicated. Methods: This prospective observational study was carried out on 50 neonates diagnosed as cases of BPD with gestational age ranging from 28w to 38w. Urea, creatinine and serum CysC were measured twice, the first measurement was at the time of diagnosis of BPD and the second one was 3 days later with estimation of creatinine based Glomerular filtration rate (GFR) and cystatin based GFR.renal Doppler ultrasound was performed to measure peak systolivc velocity, end diastolic velocity and resistive index. Results: There were 7 cases with abnormal GFR According to the first creatinine based GFR. There were 16 cases with abnormal GFR according to the first cystatin C based GFR with no statistically significance difference between both measurements. 5 patients were classified to have AKI based on serum creatinine level. There was statistically significant increase in 1st, 2nd serum creatinine, 1st and 2nd serum cystatin C levels in the AKI patients in comparison to non AKI group. On the other hand, there was statistically significant decrease in 1st, 2nd creatinine based GFR, 1st and 2nd cystatin C based GFR. There was statistically significant increase in mortality in the AKI patients if compared to non AKI patient. There was statistically significant increase in SBP, DPB and PCO2 in the AKI patients in comparison to non AKI group. Conclusions: Measurement of serum CysC and estimation of cystatin based GFR can help in early detection of cases with renal malfunction among the patients with BPD before rise of serum creatinine Early diagnosis will lead to improvement of the outcome and shortening of the hospital stay.

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