scholarly journals Effect of MACC1 Genetic Polymorphisms and Environmental Risk Factors in the Occurrence of Oral Squamous Cell Carcinoma

2021 ◽  
Vol 11 (6) ◽  
pp. 490
Author(s):  
Rei-Hsing Hu ◽  
Chun-Yi Chuang ◽  
Chiao-Wen Lin ◽  
Shih-Chi Su ◽  
Lun-Ching Chang ◽  
...  

MACC1 (Metastasis Associated in Colon Cancer 1) is found to regulate the hepatocyte growth factor (HGF)/Met signal pathway, and plays an important role in tumor proliferation, angiogenesis, and metastasis. However, the relationships between MACC1 SNPs (single nucleotide polymorphisms) and oral cancer are still blurred. In this study, five SNPs (rs3095007, rs1990172, rs4721888, rs975263, and rs3735615) were genotyped in 911 oral cancer patients and 1200 healthy individuals by real-time polymerase chain reaction (PCR), and the associations of oral cancer with the SNP genotypes, environmental risk factors, and clinicopathological characteristics were further analyzed. Our results showed that individuals who had GC genotype or C-allele (GC + CC) in rs4721888 would have a higher risk for oral cancer incidence than GG genotype after adjustment for betel quid chewing, cigarette smoking, and alcohol drinking. Moreover, the 715 oral cancer patients with a betel quid chewing habit, who had C-allele (TC + CC) in rs975263, would have a higher risk for lymph node metastasis. Further analyses of the sequences of rs4721888 revealed that the C-allele of rs4721888 would be a putative exonic splicing enhancer. In conclusion, MACC1 SNP rs4721888 would elevate the susceptibility for oral cancer, and SNP rs975263 would increase the metastasis risk for oral cancer patients with a betel quid chewing habit. Our data suggest that SNP rs4721888 could be a putative genetic marker for oral cancer, and SNP rs975362 may have the potential to be a prognostic marker of metastasis in an oral cancer patient.

1999 ◽  
Vol 20 (12) ◽  
pp. 2331-2334 ◽  
Author(s):  
Chiu-Lan Chen ◽  
Chin-Wen Chi ◽  
Kuo-Wei Chang ◽  
Tsung-Yun Liu

Oral Oncology ◽  
2004 ◽  
Vol 40 (4) ◽  
pp. 418-426 ◽  
Author(s):  
Wan-Chi Tsai ◽  
Sen-Tien Tsai ◽  
Jenq-Yuh Ko ◽  
Ying-Tai Jin ◽  
Ching Li ◽  
...  

2009 ◽  
Vol 37 (6) ◽  
pp. 555-561 ◽  
Author(s):  
Kuo-Yang Tsai ◽  
Che-Chun Su ◽  
Yo-Yu Lin ◽  
Jian-An Chung ◽  
Ie-Bin Lian

2018 ◽  
Vol 97 (6) ◽  
pp. 717-724 ◽  
Author(s):  
S.C. Su ◽  
M.J. Hsieh ◽  
C.W. Lin ◽  
C.Y. Chuang ◽  
Y.F. Liu ◽  
...  

Genetic and acquired factors are thought to be interrelated and imperative to estimate the risk and prognosis of oral squamous cell carcinoma (OSCC). HOX transcript antisense intergenic RNA ( HOTAIR) plays crucial roles in gene regulation and is regulated in a variety of cancers. Polymorphisms in HOTAIR have been recently linked to the predisposition to diverse malignancies. In the present study, we aimed to evaluate the influences of HOTAIR gene polymorphisms, combined with environmental triggers, on the susceptibility to oral tumorigenesis. Four single-nucleotide polymorphisms of the HOTAIR gene— rs920778, rs1899663, rs4759314, and rs12427129—were tested in 1,200 control participants and 907 patients with OSCC. We detected a significant association of rs1899663 with the risk of OSCC (adjusted odds ratio, 2.227; 95% confidence interval [95% CI], 1.197 to 4.146; P = 0.012) after adjustment for 3 potential confounders: smoking, betel quid chewing, and alcohol consumption. In further analyses where habitual exposure to each of 3 environmental factors was excluded, we found that, in addition to rs1899663, non–betel quid users who carried the polymorphic allele of rs920778 were more prone to develop OSCC than were those homozygous for wild-type allele (TC: odds ratio [OR], 1.472; 95% CI, 1.069 to 2.029; P = 0.018; TC+CC: OR, 1.448; 95% CI, 1.060 to 1.977; P = 0.020). Moreover, in exploring the relationship between HOTAIR gene polymorphisms and the clinical status of only patients with OSCC who were non–betel quid chewers (excluding the advanced clinical stage), we found that rs920778 and rs4759314 were correlated with the development of large-size tumors (OR, 1.891; 95% CI, 1.027 to 3.484; P = 0.04) and increased lymph node metastasis (OR, 4.140; 95% CI, 1.785 to 9.602; P = 0.001), respectively. Further functional assessments link rs920778 to the regulation of HOTAIR expression and epigenetic status. Our results reveal an interactive effect of HOTAIR gene polymorphisms and betel quid chewing on the development and progression of oral cancer.


PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0199503 ◽  
Author(s):  
Chen-Yi Lee ◽  
Chih-Feng Wu ◽  
Chun-Ming Chen ◽  
Yong-Yuan Chang

Author(s):  
Takumi Hasegawa ◽  
Nanae Yatagai ◽  
Tatsuya Furukawa ◽  
Emi Wakui ◽  
Izumi Saito ◽  
...  

Abstract Background This prospective study investigated the change of swallowing ability using the Swallowing Ability Scale System (SASS) and swallowing-related quality of life (QOL) by Performance Status Scale for Head and Neck Cancer patients (PSS-H&N). This study also investigated the risk factors for postoperative dysphagia in patients who received reconstructive surgery for oral cancer. Subjects and Methods This study included 64 patients (33 men and 31 women) who underwent radical surgery with neck dissection and reconstructive surgery for oral cancers between July 2014 and February 2018. We evaluated risk factors for poor swallowing ability after treatment, including demographic factors, preoperative factors and perioperative factors, with univariate and multivariate analyses. The change of swallowing ability by the SASS and swallowing-related QOL by PSS-H&N were evaluated prospectively prior to the initiation of surgery within 1 week and at 1 and 3 months after treatment. Results Advanced T stage (T3, 4) (odds ratio (OR) = 79.71), bilateral neck dissection (OR = 20.66) and the resection of unilateral or bilateral suprahyoid muscles (OR = 17.00) were associated with poor swallowing ability after treatment. The scores for time for food intake and Eating in Public were associated with decrease of QOL in the poor group. Conclusions We propose that clinicians consider the risk factors identified in this study and pay close attention to the management of oral cancer patients with reconstructive surgery. Graphical abstract


2019 ◽  
Vol 65 (7) ◽  
pp. 440-446
Author(s):  
Kanako TSUBOI ◽  
Akira SATOH ◽  
Takeshi KUROSHIMA ◽  
Kenji IMAMACHI ◽  
Kazuhito YOSHIKAWA ◽  
...  

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