scholarly journals Current Therapeutic Approach to Acute Myocardial Infarction in Patients with Congenital Hemophilia

Life ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1072
Author(s):  
Minerva Codruta Badescu ◽  
Manuela Ciocoiu ◽  
Elena Rezus ◽  
Oana Viola Badulescu ◽  
Daniela Maria Tanase ◽  
...  

Advances in the treatment of hemophilia have made the life expectancy of hemophiliacs similar to that of the general population. Physicians have begun to face age-related diseases not previously encountered in individuals with hemophilia. Treatment of acute myocardial infarction (AMI) is particularly challenging because the therapeutic strategies influence both the patient’s thrombotic and hemorrhagic risk. As progress has been made in the treatment of AMI over the last decade, we performed an in-depth analysis of the available literature, highlighting the latest advances in the therapy of AMI in hemophiliacs. It is generally accepted that after the optimal substitution therapy has been provided, patients with hemophilia should be treated in the same way as those in the general population. New-generation stents that allow short dual antiplatelet therapy and potent P2Y12 receptor inhibitors have begun to be successfully used. At a time when specific recommendations and relevant data are scarce, our study provides up-to-date information to physicians involved in the treatment of AMI in hemophiliacs.

BMJ Open ◽  
2017 ◽  
Vol 7 (8) ◽  
pp. e014787 ◽  
Author(s):  
Søren Toksvig Klitkou ◽  
Knut R Wangen

BackgroundAlthough there is a broad societal interest in socioeconomic differences in survival after an acute myocardial infarction, only a few studies have investigated how such differences relate to the survival in general population groups. We aimed to investigate education-specific survival after acute myocardial infarction and to compare this with the survival of corresponding groups in the general population.MethodsOur study included the entire population of Norwegian patients admitted to hospitals for acute myocardial infarction during 2008–2010, with a 6- year follow-up period. Patient survival was measured relative to the expected survival in the general population for three educational groups: primary, secondary and tertiary. Education, sex, age and calendar year-specific expected survival were obtained from population life tables and adjusted for the presence of infarction-related mortality.ResultsSix-year patient survivals were 56.3% (55.3–57.2) and 65.5% (65.6–69.3) for the primary and tertiary educational groups (95% CIs), respectively. Also 6-year relative survival was markedly lower for the primary educational group: 70.2% (68.6–71.8) versus 81.2% (77.4–84.4). Throughout the follow-up period, patient survival tended to remain lower than the survival in the general population with the same educational background.ConclusionBoth patient survival and relative survival after acute myocardial infarction are positively associated with educational level. Our findings may suggest that secondary prevention has been more effective for the highly educated.


2000 ◽  
Vol 30 (10) ◽  
pp. 1245 ◽  
Author(s):  
Boyoung Chung ◽  
Jong Won Ha ◽  
Donghoon Choi ◽  
Yangsoo Jang ◽  
Shin Ki Ahn ◽  
...  

1980 ◽  
Vol 26 (12) ◽  
pp. 1662-1665 ◽  
Author(s):  
M Speich ◽  
B Bousquet ◽  
G Nicolas

Abstract Atomic absorption spectrometry was used to measure magnesium, calcium, and sodium, and emission spectrometry to measure potassium, in myocardium (left and right ventricles) of 26 control subjects who died of acute trauma. Results were expressed in mumol/g of proteins. Mg/Ca and K/Na ratios were also determined. The same measurements were made in 24 patients who died from acute myocardial infarction. Samples were also taken from the necrotic area. Mg/Ca and K/Na ratios were significantly higher in the left ventricle of both populations, thus providing evidence of anatomical and physiological differences between the two ventricles. As a result of cytolysis and anoxia, the Mg/Ca ratio was very significantly inverted, and the K/Na ratio very significantly smaller, for samples from the necrotic area. In these clinical conditions arrhythmias could certainly be considered likely, and there is reason to believe that magnesium depletion may be a cause of arrhythmias.


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