scholarly journals Synthesis and Cytotoxic Potential of 3-oxo-19β-Trifluoroacetoxy-18αH-oleane-28-oic Acid

Molbank ◽  
10.3390/m1222 ◽  
2021 ◽  
Vol 2021 (2) ◽  
pp. M1222
Author(s):  
Elmira F. Khusnutdinova ◽  
Alexander I. Poptsov ◽  
Oxana B. Kazakova
Keyword(s):  
Breast Cancer ◽  
Prostate Cancer ◽  
Prostate Cancer Cell ◽  
2D Nmr ◽  
Cytotoxic Potential ◽  
Prostate Cancer Cell Lines ◽  
Cancer Breast ◽  
Biological Potency ◽  
Primary Evaluation ◽  
Type 3

Trifluoroacetic acid-promoted Wagner-Meerwein rearrangement of betulonic acid carboxamide led to the formation of the expected 19β,28-lactam along with a new germanicane-type 3-oxo-19β-trifluoroacetoxy-18αH-oleane-28-oic acid. The structure of this triterpenoid was confirmed by 2D NMR analyses. A primary evaluation of biological potency revealed an anticancer activity with GI50 < 5 μM against leukemia, colon cancer, breast cancer, and prostate cancer cell lines, while the parent compounds were not active.

Synthesis and Anti‐proliferative Activity of N , N′ ‐bis‐substituted 1,2,4‐Triazolium Salts against Breast Cancer and Prostate Cancer Cell Lines

2018 ◽  
Author(s):  
Zi Jie Lin ◽  
Jared Bies ◽  
Shanina S. Johnson ◽  
John D. Gorden ◽  
Jacqueline F. Strickland ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prostate Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Proliferative Activity ◽  
Prostate Cancer Cell ◽  
Cancer Cell Lines ◽  
Prostate Cancer Cell Lines ◽  
Triazolium Salts

1121: The Cytoprotective Chaperone, Clusterin, is Associated with Docetaxel-Resistance in Prostate Cancer Cell Lines: Implications in Second-Line Strategies for Metastatic HRPC

2007 ◽  
Vol 177 (4S) ◽  
pp. 370-370
Author(s):  
Richard D. Sowery ◽  
Boris A. Hadaschik ◽  
Ladan Fazli ◽  
Susan Ettinger ◽  
Alan I. So ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Lines ◽  
Second Line ◽  
Prostate Cancer Cell Lines ◽  
Docetaxel Resistance

797: Noggin Blocks the Osteoinductive Properties of Human Prostate Cancer Cell Lines

2006 ◽  
Vol 175 (4S) ◽  
pp. 258-258
Author(s):  
Ruth Schwaninger ◽  
Cyrill A. Rentsch ◽  
Antoinette Wetterwald ◽  
Irena Klima ◽  
Gabri Van der Pluijm ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Lines ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Human Prostate Cancer Cell ◽  
Prostate Cancer Cell Lines

Expression of Urokinase and Its Receptor in Invasive and Non-Invasive Prostate Cancer Cell Lines

1992 ◽  
Vol 68 (06) ◽  
pp. 662-666 ◽  
Author(s):  
W Hollas ◽  
N Hoosein ◽  
L W K Chung ◽  
A Mazar ◽  
J Henkin ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Steady State ◽  
Cell Surface ◽  
Cell Lines ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Lines ◽  
Lncap Cells ◽  
Prostate Cancer Cell Lines ◽  
Non Invasive

SummaryWe previously reported that extracellular matrix invasion by the prostate cancer cell lines, PC-3 and DU-145 was contingent on endogenous urokinase being bound to a specific cell surface receptor. The present study was undertaken to characterize the expression of both urokinase and its receptor in the non-invasive LNCaP and the invasive PC-3 and DU-145 prostate cells. Northern blotting indicated that the invasive PC-3 cells, which secreted 10 times more urokinase (680 ng/ml per 106 cells per 48 h) than DU-145 cells (63 ng/ml per 106 cells per 48 h), had the most abundant transcript for the plasminogen activator. This, at least, partly reflected a 3 fold amplification of the urokinase gene in the PC-3 cells. In contrast, urokinase-specific transcript could not be detected in the non-invasive LNCaP cells previously characterized as being negative for urokinase protein. Southern blotting indicated that this was not a consequence of deletion of the urokinase gene. Crosslinking of radiolabelled aminoterminal fragment of urokinase to the cell surface indicated the presence of a 51 kDa receptor in extracts of the invasive PC-3 and DU-145 cells but not in extracts of the non-invasive LNCaP cells. The amount of binding protein correlated well with binding capacities calculated by Scatchard analysis. In contrast, the steady state level of urokinase receptor transcript was a poor predictor of receptor display. PC-3 cells, which were equipped with 25,000 receptors per cell had 2.5 fold more steady state transcript than DU-145 cells which displayed 93,000 binding sites per cell.

Relationship of STAT3 activity with chemosensitivity to cisplatin in prostate cancer cell lines

2012 ◽  
Vol 32 (2) ◽  
pp. 150-154
Author(s):  
Hui HAN ◽  
Chun-yan LI ◽  
Xi LIU ◽  
Li CHU ◽  
Qing XU
Keyword(s):  
Prostate Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Lines ◽  
Prostate Cancer Cell Lines ◽  
Relationship Of
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