A Combined Approach of Double Network Hydrogel and Nanocomposites Based on Hyaluronic Acid and Poly(ethylene glycol) Diacrylate Blend

In this study, an innovative polymer blend, based on double network (DN) approach, has been developed by integrating a poly(ethylene glycol) diacrylate (PEGDA) network into a chemically modified hyaluronic acid sodium salt (HAs) hydrogel matrix. Here, the HAs was chemically functionalized with photocrosslinkable moieties by reacting with maleic anhydride (MAA) to obtain a maleated hyaluronic acid (MaHA). Furthermore, nanocomposite DN hydrogels were suitably prepared by physical blending of hydroxyapatite nanoparticles (HAp), obtained by sol-gel synthesis, within the hydrogel. Physico-chemical, thermal, morphological and mechanical analyses were performed. Results showed enhanced mechanical properties and a homogenous microstructure as highlighted by mechanical and morphological investigations. This suggests that nanocomposite DN hydrogels are promising candidates for biomedical applications.

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Poly(ethylene glycol) as structure directing agent in sol–gel synthesis of amorphous silica

Microporous and Mesoporous Materials ◽

10.1016/j.micromeso.2014.02.013 ◽

2014 ◽

Vol 190 ◽

pp. 146-151 ◽

Cited By ~ 10

Author(s):

O.V. Gorbunova ◽

O.N. Baklanova ◽

T.I. Gulyaeva ◽

M.V. Trenikhin ◽

V.A. Drozdov

Keyword(s):

Ethylene Glycol ◽

Amorphous Silica ◽

Sol Gel ◽

Poly Ethylene Glycol ◽

Structure Directing Agent ◽

Poly Ethylene ◽

Sol Gel Synthesis

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Sol-gel synthesis of cubic titanium dioxide nanoparticle using poly(ethylene glycol) as a capping agent: voltammetric simultaneous determination of uric acid and guanine

Microchimica Acta ◽

10.1007/s00604-018-3042-9 ◽

2018 ◽

Vol 185 (11) ◽

Cited By ~ 9

Author(s):

Sudip Biswas ◽

Susmita Pradhan ◽

Hemanta Naskar ◽

Rajib Bandyopadhyay ◽

Panchanan Pramanik

Keyword(s):

Titanium Dioxide ◽

Uric Acid ◽

Ethylene Glycol ◽

Sol Gel ◽

Capping Agent ◽

Poly Ethylene Glycol ◽

Titanium Dioxide Nanoparticle ◽

Poly Ethylene ◽

Sol Gel Synthesis

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Injectable microfluidic hydrogel microspheres based on chitosan and poly(ethylene glycol) diacrylate (PEGDA) as chondrocyte carriers

RSC Advances ◽

10.1039/d0ra07318k ◽

2020 ◽

Vol 10 (65) ◽

pp. 39662-39672

Author(s):

Lin Lin ◽

Yanfang Wang ◽

Ling Wang ◽

Jianying Pan ◽

Yichao Xu ◽

...

Keyword(s):

Tissue Engineering ◽

Ethylene Glycol ◽

Cartilage Tissue Engineering ◽

Cartilage Tissue ◽

Poly Ethylene Glycol ◽

Bottom Up ◽

Double Network ◽

Glycol Diacrylate ◽

Poly Ethylene ◽

Hydrogel Microspheres

Chitosan/PEGDA double-network hydrogel microspheres prepared by microfluidic method as chondrocyte carriers for bottom-up cartilage tissue engineering.

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Micropatterning of Poly (Ethylene Glycol)-Diacrylate (PEG-DA) Hydrogel by Soft-Photolithography for Analysis of Cell-Biomaterial Interactions

Journal of Biomimetics Biomaterials and Tissue Engineering ◽

10.4028/www.scientific.net/jbbte.2.3 ◽

2009 ◽

Vol 2 ◽

pp. 3-14 ◽

Cited By ~ 5

Author(s):

Karthikeyan Subramani ◽

M.A. Birch

Keyword(s):

Ethylene Glycol ◽

Three Dimensional ◽

Poly Ethylene Glycol ◽

Contact Printing ◽

Pdms Stamp ◽

Glycol Diacrylate ◽

Dimethyl Siloxane ◽

Hydrogel Matrix ◽

Poly Ethylene ◽

Innovative Techniques

Poly (ethylene glycol) hydrogel (PEG) micropatterns fabricated by photolithography and various other microfabrication techniques have been used as a platform to analyze cell-biomaterial interactions in cell culture studies. Numerous innovative techniques have been described about photolithography and the use of Poly (dimethyl siloxane) stamp (PDMS) based pressure moulding technique for the microfabrication of PEG hydrogel micropatterns. We herein this literature describe a simple and a versatile method for fabricating Poly (ethylene glycol) hydrogel-diacrylate (PEG-DA) hydrogel micropatterns using the ‘Soft-photolithography’ technique which is a combination of pressure moulding using a PDMS stamp and photolithography. Using this simple technique, PEG-DA hydrogel micropatterns were fabricated on a silicon substrate of varying dimensions from 40μm to 10μm within the same substrate. Such a three-dimensional microenvironment with varying sizes can serve as an excellent platform to study cell behaviour in culture. These PEG-DA hydrogel micropatterns can further be functionalized by adding a variety of biomolecular cues within the PEG-DA hydrogel matrix or these biomolecules can be patterned on the PEG-DA micropatterns after photopolymerization using micro-contact printing for analysis of cell-biomaterial interactions and tissue engineering purposes.

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