scholarly journals Cembranoids from Octocoral Lobophytum crassum (von Marenzeller, 1886)

Marine Drugs ◽  
2021 ◽  
Vol 19 (3) ◽  
pp. 130
Author(s):  
Yao-Tsung Yeh ◽  
Sung-Chun Lin ◽  
Gene-Hsiang Lee ◽  
Zhi-Hong Wen ◽  
Tsong-Long Hwang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Biological Activity ◽  
Solvent Extraction ◽  
Raw 264.7 ◽  
Mouse Macrophage ◽  
X Ray Diffraction ◽  
X Ray ◽  
Protein Expressions ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Two cembranoids, including a new compound, lobocrassin I (1), as well as a known analogue, lobohedleolide (2), were obtained by solvent extraction from octocoral Lobophytum crassum. This study employed a spectroscopic approach to establish the structures of these two cembranoids, and utilized single-crystal X-ray diffraction analysis to determine their absolute configurations. The results of biological activity assays demonstrated that cembranoid 2 exhibited bioactivity against the protein expressions of inducible nitric oxide synthase (iNOS) lipopolysaccharide (LPS)-treated RAW 264.7 mouse macrophage cells.

scholarly journals Briarenols W–Z: Chlorine-Containing Polyoxygenated Briaranes from Octocoral Briareum stechei (Kükenthal, 1908)

Marine Drugs ◽  
2021 ◽  
Vol 19 (2) ◽  
pp. 77
Author(s):  
You-Ying Chen ◽  
Yi-Lin Zhang ◽  
Gene-Hsiang Lee ◽  
Lun Kelvin Tsou ◽  
Mingzi M. Zhang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Spectroscopic Analysis ◽  
Raw 264.7 ◽  
Mouse Macrophage ◽  
X Ray Diffraction ◽  
X Ray ◽  
Carbon Core ◽  
Cox 2 ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Briareum stechei is proven to be a rich source of 3,8-cyclized cembranoids (briarane) with a bicyclo[8.4.0] carbon core. In the present study, four previously unreported briaranes, briarenols W–Z (1–4), along with solenolide A (5), briarenolide M (6), briaexcavatolide F (7), and brianolide (8), were isolated and characterized through spectroscopic analysis, and the absolute configuration of 8 was corroborated by a single-crystal x-ray diffraction analysis. Briaranes 2 and 5 were found to induce significant inflammatory activity in lipopolysaccharide (LPS)-induced RAW 264.7 mouse macrophage cells by enhancing the expression of the inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins.

scholarly journals Briarane-Related Diterpenoids from Octocoral Briareum stechei

Molecules ◽  
2021 ◽  
Vol 26 (22) ◽  
pp. 6861
Author(s):  
Thanh-Hao Huynh ◽  
Choo-Aun Neoh ◽  
Yu-Chi Tsai ◽  
Zhi-Kang Yao ◽  
Li-Guo Zheng ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Raw 264.7 ◽  
Spectroscopic Methods ◽  
Mouse Macrophage ◽  
Inos Protein ◽  
New Compounds ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

A known polyoxygenated briarane, briaexcavatolide P (1), was isolated from a Formosan octocoral Briareum stechei. Moreover, the same species B. stechei, collected from Okinawan waters, yielded three chlorine-containing briaranes, including two new compounds, briastecholides B (2) and C (3) as well as a known analogue, briarenol R (4). The structures of 1–4 were established using spectroscopic methods. In addition, briarane 1 demonstrated anti-inflammatory activity in lipo-polysaccharide-induced RAW 264.7 mouse macrophage cells by suppressing the expression of inducible nitric oxide synthase (iNOS) protein.

scholarly journals 8-Hydroxybriaranes from Octocoral Briareum stechei (Briareidae) (Kükenthal, 1908)

Marine Drugs ◽  
2021 ◽  
Vol 19 (3) ◽  
pp. 136
Author(s):  
Thanh-Hao Huynh ◽  
Su-Ying Chien ◽  
Junichi Tanaka ◽  
Zhi-Hong Wen ◽  
Yang-Chang Wu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Diffraction Analysis ◽  
Inducible Nitric Oxide Synthase ◽  
Absolute Configuration ◽  
Spectroscopic Analysis ◽  
X Ray Diffraction ◽  
X Ray ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Chemical investigation of the octocoral Briareum stechei, collected in the Ie Island, Okinawa, Japan, resulted in the isolation of a new briarane-type diterpenoid, briastecholide A (1), as well as the previously reported metabolites, solenolide C (2) and briarenolide S (3). The structures of briaranes 1–3 were characterized through spectroscopic analysis, and the absolute configuration of 2 was corroborated by a single-crystal X-ray diffraction analysis. Briarane 3 exhibited bioactivity against the protein expression of inducible nitric oxide synthase (iNOS).

scholarly journals Briarenols I—K, New Anti-inflammatory 8,17-Epoxybriaranes from the Octocoral Briareum excavatum (Briareidae)

Molecules ◽  
2020 ◽  
Vol 25 (6) ◽  
pp. 1405 ◽  
Author(s):  
Thanh-Hao Huynh ◽  
Lee-Shing Fang ◽  
Yu-Hsin Chen ◽  
Bo-Rong Peng ◽  
You-Ying Chen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Inducible Nitric Oxide Synthase ◽  
2D Nmr ◽  
Raw 264.7 ◽  
Spectroscopic Methods ◽  
Nmr Studies ◽  
Cox 2 ◽  
New Compounds ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Five 8,17-epoxybriaranes, including three new compounds—briarenols I–K (1–3), along with two known analogues, briaexcavatolide P (4) and briaexcavatin P (5), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1–3 were elucidated by spectroscopic methods, including 1D and 2D NMR studies and (+)-HRESIMS. Briarane 4 exerted inhibition effects on inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) release from RAW 264.7.

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