scholarly journals Topical 5% Imiquimod Sequential to Surgery for HPV-Related Squamous Cell Carcinoma of the Lip

Medicina ◽  
2021 ◽  
Vol 57 (6) ◽  
pp. 563
Author(s):  
Giovanni Pentangelo ◽  
Steven Paul Nisticò ◽  
Eugenio Provenzano ◽  
Giusy Ylenia Cisale ◽  
Luigi Bennardo
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Hpv Infection ◽  
Lower Lip ◽  
Papilloma Virus ◽  
Surgical Scar ◽  
The Face ◽  
Well Differentiated ◽  
Oral Area

Background: Squamous cell carcinoma (SCC) is one of the most common neoplasms affecting the oral cavity and the face. Its more differentiated forms may be associated with human papilloma virus (HPV) infection. Case report: In this paper, we report the case of an 86-year-old patient with a well-differentiated SCC of the lower lip associated with HPV treated with surgery with a non-complete histological resolution. Imiquimod 5% cream was applied on the surgical scar once a day for two weeks and then once a week. Two years after SCC removal, no relapse has occurred. Conclusions: Topical imiquimod may be a safe and effective treatment after surgery in SCC of the oral area to reduce the risk of relapses.

scholarly journals Human papillomavirus-associated oropharyngeal carcinoma: trends in epidemiology and methods for detecting the virus in tumors

2018 ◽  
Vol 8 (3) ◽  
pp. 77-83
Author(s):  
A. I. Stukan' ◽  
O. Yu. Chukhray ◽  
V. A. Porkhanov ◽  
R. A. Murashko ◽  
V. N. Bodnya ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
White Men ◽  
Hpv Infection ◽  
Heavy Smoker ◽  
Oropharyngeal Carcinoma ◽  
Papilloma Virus ◽  
Former Smokers

Oropharyngeal squamous cell carcinoma has been traditionally associated with tobacco and alcohol consumption. Nevertheless, latter 30 years have shown squamous cell carcinoma (OPSCC) incidence stagnation and increasing, despite the decrease in smoking prevalence. The incidence was recognized among white men of middle age, often non-smokers or former smokers in the investigations with smoking cessation data. It differs from traditional patient with OPSCC, older men, heavy smoker or alcohol drinker. The incidence of OPSCC is increased due human papilloma virus (HPV) infection. The infection transition is associated with sex and oro-genital contact may lead to HPV-infection of oropharynx and oral cavity. There are multiple types of HPV, but the majority of OPSCC is associated with HPV 16 type. Epidemiology of HPV-associated OPSCC, HPV-infection of oral cavity and/or oropharynx and HPV detection are discussed in the review.

scholarly journals Assessment of Role of Human Papilloma Virus in Patients with Oral Squamous Cell Carcinoma

2019 ◽  
Vol 15 (2) ◽  
pp. 125-127
Author(s):  
Krishan Kumar Tyagi ◽  
Megha Pradhan ◽  
Rajbir Kaur Grewal ◽  
Prabesh Sherchan ◽  
KSA Pasha
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Human Papilloma Virus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Control Group ◽  
Papilloma Virus ◽  
Mucosal Tissues ◽  
Well Differentiated

Background: Head and neck malignancies include malignancies instigating in the oral cavity, the orophar-ynx, the hypopharynx and the larynx. We planned the present study to assess the role of human papilloma virus (HPV) in patients with oral squamous cell carcinoma (OSCC). Methods: The present study included assessment of role of human papilloma virus in patients with oral squamous cell carcinoma. A total of 50 histopathologic proven cases of well differentiated OSCC were included in the present study. A total of 50 healthy oral mucosal tissues (controls) were also included in the present study. The controls were obtained while surgical removing the impacted teeth. DNA was obtained from the tissue sections and underwent Polymerization chain reaction for identification of HPV 16/18. All the results were summarized in Microsoft excel sheet and were analyzed by SPSS software. Results: HPV was absent in all the cases of control group, whereas among the OSCC group, the HPV was detected in 46 percent of the cases. In the remaining 54 per-cent of the cases of the OSCC group, HPV was absent. Significant results were obtained while comparing the presence of HPV in between the OSCC group and the control group. Conclusions: HPV was present in sig-nificant number of OSCC cases. Therefore; HPV might play a contributing role in the etio-pathogenesis of OSCC.

LOWER LIP SQUAMOUS CELL CARCINOMA WITH EXUBERANT PRESENTATION IN THE FACE: A CASE REPORT

2020 ◽  
Vol 129 (1) ◽  
pp. e114
Author(s):  
ALINE CACHATE DE FARIAS ◽  
CAMILA MARIA BEDER RIBEIRO G. PANJWANI ◽  
CATARINA RODRIGUES ROSA DE OLIVEIRA ◽  
JANE MARQUES DA SILVA ◽  
ARTHUR ERIC COSTA WANDERLEY ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lower Lip ◽  
The Face

scholarly journals Squamous Cell Carcinoma Arising within Verruca Vulgaris on the Nipple

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Araya Zaesim ◽  
Amanda C. Jackson ◽  
Sang Wook Lee ◽  
Shaun A. Price
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Chronic Wounds ◽  
Hpv Infection ◽  
Cumulative Exposure ◽  
Verruca Vulgaris ◽  
Underlying Malignancy ◽  
Well Differentiated ◽  
Associated Risk Factors

Cutaneous squamous cell carcinoma (SCC) is a common form of skin cancer and often appears as a hard, scaly lump that occasionally ulcerates. It is usually associated with cumulative exposure to ultraviolet light, although prior scarring, chronic wounds, exposure to radiation, HPV infection, and immunosuppression are also associated risk factors. Primary SCC of the nipple is very rare and only a few cases have been reported. We present a case of a 49-year-old female with concerns of a right nipple lesion with erythema and pain. She was initially evaluated for Paget’s disease with an underlying malignancy and cellulitis, but, after biopsy and investigation, she was found to have a well-differentiated SCC arising from a verruca vulgaris. Current literature does not provide distinct guidelines on management of SCC or its variants on the nipple, and the case was managed based off of SCC at other cutaneous sites as well as other cases of SCC on the nipple.

scholarly journals Destructive, multifocal squamous-cell carcinoma nodules on the cheecks and neck of an elderly woman with a dementia syndrome

2013 ◽  
pp. 185-188
Author(s):  
Norma Marigliano ◽  
Manuela Colosimo ◽  
Marcella Flocco ◽  
Francesca Mazzei ◽  
Maria V. Sirianni ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Nursing Home ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Normal Skin ◽  
Neck Region ◽  
Dementia Syndrome ◽  
Diagnosis Of Dementia ◽  
The Face ◽  
Well Differentiated

Introduction: Squamous-cell carcinoma is the second most common form of skin cancer. It can develop on normal skin, actinic keratoses, leukoplakia, and burn scars. The tumor is characterized by remarkable variability at the macroscopic and histopathologic levels. Case report: A 93-year-old woman was admitted to nursing home with a diagnosis of dementia syndrome and squamous cell nodular carcinoma on cheeks and neck region. The physical examination revealed firm, black excrescences with irregular surfaces over both cheekbones, which were roughly the size of hazelnuts. Similar nodules were present with ulcers on other areas of the face. The patient was admitted to the day hospital twice for wide excision of the tumors in the zygomatic region. Later, the neck tumors were removed, and the wound was repaired with a rotation flap after careful control of bleeding. For the latter surgery, the patient was hospitalized for a few days in a geriatric ward to ensure optimal medical care and psychological support. The histological examination revealed ulcerated, well-differentiated squamous-cell carcinoma that extended down to the subcutaneous layer. Shortly after surgery, she returned to the nursing home to resume rehabilitation and group therapy.

scholarly journals Human Papillomavirus and Head and Neck Squamous Cell Carcinoma: Recent Evidence and Clinical Implications

2009 ◽  
Vol 88 (4) ◽  
pp. 300-306 ◽  
Author(s):  
P.T. Hennessey ◽  
W.H. Westra ◽  
J.A. Califano
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Hpv Infection ◽  
Neck Squamous Cell Carcinoma ◽  
Papilloma Virus ◽  
Hpv Status ◽  
Potential Impact ◽  
Oral Cavity Cancers

Over the past 20 years, high-risk human papilloma-virus (HPV) infection has been established as a risk factor for developing head and neck squamous cell carcinoma, independent of tobacco and alcohol use. In particular, HPV is strongly associated with the development of oropharyngeal cancer and a small minority of oral cavity cancers. In this review, we summarize what is currently known about the biology of HPV, the mechanisms by which it effects malignant transformation, and the potential impact of HPV status on the clinical management of persons with head and neck cancer.

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