scholarly journals The Use of Biochemical and Biophysical Markers in Early Screening for Preeclampsia in Mongolia

2018 ◽  
Vol 6 (3) ◽  
pp. 57
Author(s):  
Urjindelger Tserensambuu ◽  
Ariunbold Chuluun-Erdene ◽  
Munkhtsetseg Janlav ◽  
Erkhembaatar Tudevdorj
Keyword(s):  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Pulsatility Index ◽  
Uterine Artery ◽  
Maternal Serum ◽  
Operating Characteristics ◽  
Early Screening ◽  
Roc Curve Analysis ◽  
Detection Rates ◽  
The Mean

Preeclampsia (PE) is a major cause of maternal and perinatal morbidity and mortality, particularly in developing countries. In Mongolia, preeclampsia and eclampsia have occurred among pregnancy complications at a rate of 25% in recent years. Recent studies in the literature have screened for preeclampsia by combining maternal factors with biomarkers. This study was conducted using prospective cohort research including 393 singleton pregnancies at 11–13+6 weeks. Maternal plasmas pregnancy-associated plasma protein-A (PAPP-A) and maternal serum placental growth factor (PlGF) were measured using Perkin Elmer time-resolved fluoroimmunoassay (DELFIA) kits, and the measurement of mean arterial pressure (MAP) was performed by automated devices and the uterine artery pulsatility index was measured by Doppler ultrasound. In the study population, there were 16.7% showing complicated preeclampsia. The receiver-operating characteristics (ROC) curve analysis showed a sensitivity of 71.21%, and a specificity of 75.54% when the mean arterial pressure cut-off was 89.5 mm; while a sensitivity of 33.36% and specificity of 77.68% were observed when the uterine artery mean pulsatility index (mPI) cut-off was 2.34; a sensitivity of 79.66% and specificity of 44.04% were observed when the PAPP-A cut-off was 529.1 mU/L; and a sensitivity of 74.58% and specificity of 46.6% were observed when the PlGF cut-off was 39.87 pg/mL. The detection rates following the combination of markers with the maternal history were as follows: 62.7% with mean arterial pressure, 69.5–82.9% with two markers 86.5% with three markers and 91.4% with four markers. In conclusion, the mean arterial pressure was highly sensitive and demonstrated its easy usage and cost-effectiveness as a predictive marker for the early screening of preeclampsia from other biomarkers.

Competing Risk Model in Screening for Preeclampsia by Mean Arterial Pressure and Uterine Artery Pulsatility Index at 30-33 Weeks' Gestation

2014 ◽  
Vol 36 (1) ◽  
pp. 18-27 ◽  
Author(s):  
Ahmet Tayyar ◽  
Santiago Garcia-Tizon Larroca ◽  
Leona C. Poon ◽  
David Wright ◽  
Kypros H. Nicolaides
Keyword(s):  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Pulsatility Index ◽  
Uterine Artery ◽  
Risk Model ◽  
Competing Risk ◽  
Competing Risk Model

Прогнозирование рождения маловесного для гестационного возраста ребенка: оценка эффективности алгоритма Фонда медицины плода (Fetal Medicine Foundation) в первом триместре беременности

2019 ◽  
pp. 16-32
Keyword(s):  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Gestational Age ◽  
Pulsatility Index ◽  
Uterine Artery ◽  
Protein A ◽  
First Trimester ◽  
First Trimester Screening ◽  
Fetal Medicine ◽  
Trimester Screening

Цель исследования - оценка эффективности прогнозирования рождения маловесного для гестационного возраста (МГВ) ребенка по скрининговому алгоритму Фонда медицины плода (Fetal Medicine Foundation). В амбулаторных условиях в 2015-2017 гг. было безвыборочно обследовано 2 500 пациенток в сроках беременности от 11+1 до 13+6 нед. Критериями включения были одноплодная беременность и живой плод в полости матки на момент проведения исследования. Критерии исключения - многоплодная беременность, врожденные пороки развития и хромосомные аномалии плода. Расчет индивидуального риска рождения недоношенного МГВ ребенка осуществлялся с учетом материнских клинико-эпидемиологических характеристик, среднего артериального давления, пульсационного индекса в маточных артериях, РАРР-А в сыворотке крови матери с использованием программного комплекса (ПК) Astraia Software (version 2.8, 3.0) (Германия). Основным изучаемым исходом была масса новорожденного менее 10-го процентиля значений для данного гестационного возраста. 447 случаев были исключены из анализа по причине отсутствия информации об исходах беременности (n = 265), наличия врожденных пороков развития и хромосомных аномалий плода (n = 159), самопроизвольного прерывания беременности до 22 нед (n = 23). В итоговый анализ было включено 2 053 пациентки. 137 (6,7%) новорожденных имели массу менее 10-го процентиля, включая 37 (1,8%) недоношенных, рожденных до 37 нед беременности, и 100 (4,9%) доношенных при родах в сроке ≥37 нед. Для прогнозирования рождения недоношенного МГВ ребенка качество модели скрининга оценивалось как хорошее с AUC 0,836 (95%-й доверительный интервал (ДИ) - 0,819-0,852) (P 0,001). Оптимальный порог отсечки для определения риска рождения недоношенного МГВ ребенка для российской популяции соответствовал значению ≤ 1 : 162, обеспечивая выявление более 83,8% подобных случаев при 23,1%-й фракции ложно-положительных результатов. Для прогнозирования рождения МГВ ребенка в доношенный срок качество модели скрининга не достигло приемлемого - AUC 0,650 (95%-й ДИ - 0,633-0,675). Хорошая эффективность прогнозирования рождения недоношенного МГВ ребенка позволяет относить пациенток с положительными результатами скрининга в группу высокого риска с выработкой индивидуального алгоритма динамического наблюдения за состоянием плода. Ключевые слова: комбинированный скрининг первого триместра беременности, маловесный для гестационного возраста, ассоциированный с беременностью протеин А (РАРР-А), пульсационный индекс в маточных артериях, среднее артериальное давление, combined first-trimester screening, small-for-gestational age, pregnancy-associated plasma protein-A (PAPP-A), uterine artery pulsatility index, mean arterial pressure

scholarly journals Maternal Serum Concentrations of Corin, Endoglin, PP13, and sFlt-1 and their Changes with Advancement of Pregnancy and Correlation with Doppler of Uterine Arteries

Folia Medica ◽  
2018 ◽  
Vol 60 (4) ◽  
pp. 558-564
Author(s):  
Krasimira I. Chalova ◽  
Blagovest K. Pehlivanov ◽  
Iliya G. Amaliev ◽  
Georgi I. Amaliev ◽  
Ralitsa D. Raycheva ◽  
...  
Keyword(s):  
Pulsatility Index ◽  
Uterine Artery ◽  
Maternal Serum ◽  
Serum Concentrations ◽  
Uterine Arteries ◽  
Prediction And Prevention ◽  
Significant Difference ◽  
Gestational Week ◽  
The Mean ◽  
Experimental Group

Abstract Background: Pre-eclampsia (PE) affects 2% to 5% of all pregnancies and is a major cause of maternal and perinatal morbidity and mortality worldwide. Since PE has complex pathogenesis and treatment is still not found, effective methods for prediction and prevention of PE are still actively searched. Aim: The aim of this study was to find the mean maternal serum concentration of four proteins in Bulgarian pregnant women and to investigate the correlation with uterine artery pulsatility index in the first and second trimester of pregnancy. Materials and methods: In this prospective case-control study, maternal serum concentrations of corin, sEndoglin, PP13, and sFlt-1 were measured, pulsatility index of uterine artery (PI-UA) was assessed in 40 women with Doppler, twice during pregnancy – at the 11th – 13th weeks of gestation and the 20th gestational week. They were randomized in two groups: an experimental group: with increased PIUA at gestational week 13 and a control group: with normal PI-UA. All pregnancies were followed up until the day of delivery and outcomes were recorded. Results: There was no significant difference in the APGAR score and birth weight of the newborns between groups. We found no significant difference in the mean concentration of sEnd, sFlt-1 and PP13 between 11-13 weeks of gestation and 20 week of gestation in the control and experimental groups. Statistically significant difference was found only in the mean concentrations of corin between weeks 11-13 and week 20 in both control (t=3.27; p=0.004) and experimental group (t=3.22; p=0.005). Corin levels and the mean PI of uterine arteries tended to decrease with progression of pregnancy in both groups. Conclusions: Further prospective studies of larger populations are required to develop a panel of multiple predictors for PE.

First trimester markers of preeclampsia in twins: maternal mean arterial pressure and uterine artery Doppler pulsatility index

2014 ◽  
Vol 34 (10) ◽  
pp. 956-960 ◽  
Author(s):  
R. Svirsky ◽  
S. Yagel ◽  
I. Ben-Ami ◽  
H. Cuckle ◽  
E. Klug ◽  
...  
Keyword(s):  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Pulsatility Index ◽  
Uterine Artery ◽  
First Trimester ◽  
Uterine Artery Doppler

scholarly journals Correlation between Calcium Phosphorus Product and Mean Arterial Pressure among Hemodialysis Patients with End Stage Renal Disease

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Muhammad Nadeem ◽  
Mansoor Abbas Qaisar ◽  
Ali Hassan Al Hakami ◽  
Fateh Sher Chattah ◽  
Muhammad Muzammil ◽  
...  
Keyword(s):  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Hemodialysis Patients ◽  
Age Group ◽  
Calcium Phosphorus ◽  
The Mean ◽  
Stage Renal Disease ◽  
End Stage

Background: The mean arterial pressure serves as an expression of blood pressure in patients on chronic hemodialysis. Serum calcium phosphorus product is considered as a risk factor of vascular calcification that is associated with hypertension in the patients of end stage renal disease. The literature regarding this relationship is inconsistent therefore this study is designed to determine the correlation between calcium phosphorus product and mean arterial pressure among hemodialysis patients with end stage renal disease. Methods: A total of 110 patients of end stage renal disease on hemodialysis for at least one year, 20 to 60 years of age were included. Patients with primary or tertiary hyperparathyroidism, peripheral vascular disease, malignancy, hypertension secondary to any cause other than kidney disease were excluded. Mean arterial pressure was calculated according to the standard protocol in lying position. Blood samples for estimation of serum calcium and phosphorous were taken and was sent immediately to the laboratory for serum analysis. Results: Mean age was 44.17 ± 10.94 years. Mean calcium phosphorous product was 46.71 ± 7.36 mg/dl and mean arterial pressure was 103.61 ± 12.77 mmHg. The values of Pearson correlation co-efficient (r) were 0.863 for age group 20 to 40 years and 0.589 for age group 41 to 60 years. This strong positive correlation means that high calcium phosphorous product goes with high mean arterial pressure (and vice versa) for both the age groups. Conclusion: A strong positive relationship exists between the mean arterial pressure and calcium phosphorous product and is independent of patients’ age.

scholarly journals Hubungan Mean Arterial Pressure (MAP) Dengan Preeklamsia Pada Ibu Hamil Di Puskesmas Bontobangun Kabupaten Bulukumba

2020 ◽  
Vol 5 (2) ◽  
pp. 138-145
Author(s):  
Ely Kurniati ◽  
Rusnawati
Keyword(s):  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Pregnant Women ◽  
Sampling Method ◽  
Blood Pressure Measurement ◽  
Test Results ◽  
Historical Cohort ◽  
Measurement Results ◽  
History Of ◽  
The Mean

Preeclampsia complicates 4-7% of pregnancies and remains the leading cause of maternal and fetal morbidity and mortality worldwide. Despite improvements in health care over the last decade, preeclampsia remains the second most common cause of maternal mortality in Indonesia. This study aims to determine whether the mean arterial pressure (MAP) is related to the incidence of preeclampsia in pregnant women at the Bontobangun Puskesmas, Bulukumba district for the period 2018 to 2019. This research uses a descriptive-analytic approach with Historical Cohort Studies, namely by looking at the cohort book of the history of blood pressure measurement results for pregnant women at the Bontobangun Public Health Center, Bulukumba Regency for the period 2018 to 2019. Determining the sample using the sampling method taken by purposive sampling. 31 samples of pregnant women who experienced preeclampsia and 31 controls were pregnant women with normal conditions who had certain criteria (matching) with the sample. The results explained that from the paired T-test results, the value of α> 0.037 so that it is said that there is a relationship between mean artery pressure (MAP) and the incidence of preeclampsia in pregnant women at Bontobangun puskesmas for the period 2018-2019.

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